Administrative Core

行政核心项目摘要/摘要：行政核心提供总体 HNRC的科学领导和管理，主要目标是确保综合、连贯和 有效的科学操作。在核心内部，执行团队(ET)提供方案领导 在资源分配和未来研究方向和项目方面对中心进行监督。这个 ET的决策由外部和内部的正式审查、建议和反馈提供信息。这个 外部科学咨询委员会每年举行会议，评估中心的进展并提出未来建议 科学方向。在内部，调查委员会制定政策并密切监测科学进展。 对ET有价值的地方投入也来自社区咨询委员会(社区提供者， 倡导者和领导者)和参与者咨询委员会(研究参与者)。领导层的关键决定-- 制作功能通过四个交互组件来实现：协调单元，它具有总体 负责执行和协调中心的活动，包括组织中心的分配 资源，促进向科学界和一般社区传播信息，并确保 遵守机构和联邦政策；数据管理和统计股，负责处理 所有与中心相关的数据，确保核心和相关项目之间的无缝交互，并支持 中心网站和视频会议；统计股，为所有研究提供统计服务 从设计到最后分析的各个阶段；以及参与者应计和留用股，该股招聘以下人员 兴趣，维持纵向队列，并管理潜在研究参与者的登记。这其中的每一个 各单位还从事方法开发。此外，强大的工作组协助和指导核心： 研究审查委员会审查中心资源的申请，并作为讨论的场所 当前和拟议的研究和手稿；HNRC运营工作组，其中关键经理 和项目协调员处理项目实施和故障排除，以及人类主体 委员会，负责监督人类受试者和IRB问题，特别是与保密有关的问题。 核心的结构和流程确保了一个真正的多学科研究中心的运作，并 培养广泛的灵活性和响应性，不仅是对国家一级宣布的优先事项 政策(例如，NIH)和国家神经艾滋病研究界表达的政策(例如，我国- 广泛合作的大学)，但也在我们的国内机构(HNRC科学核心领导者，其他UCSD 艾滋病毒研究小组)。

ADMINISTRATIVE CORE PROJECT SUMMARY/ABSTRACT: The Administrative Core provides the overall scientific leadership and management for the HNRC, with a primary aim of ensuring integrated, coherent, and effective scientific operations. Within the Core, the Executive Team (ET) provides programmatic leadership and oversight of the Center regarding resource allocation and future research directions and projects. The decisions of the ET are informed by both external and internal formal review, advice and feedback. The external Scientific Advisory Board meets annually to evaluate Center progress and to recommend future scientific directions. Internally, the Council of Investigators sets policy and closely monitors scientific progress. Valued local input to the ET also comes from the Community Advisory Board (community providers, advocates, and leaders) and Participant Advisory Board (study participants). The leadership's key decision- making functions are implemented via four interacting components: the Coordinating Unit which has overall responsibility for executing and coordinating Center activities, including organizing the distribution of Center resources, facilitating information dissemination to scientific and general communities, and ensuring compliance with institutional and Federal policies; the Data Management and Statistics Unit , which processes all Center-related data, ensures seamless interaction among Cores and associated projects, and supports Center websites and videoconferencing; the Statistics Unit , which provides statistical services at all study stages, from design to final analyses; and the Participant Accrual and Retention Unit, which recruits cohorts of interest, maintains the longitudinal cohort, and manages a registry of potential study participants. Each of these Units also engages in methods development. In addition, strong working groups assist and guide the Core: the Research Review Committee reviews requests for Center resources and serves as a venue for the discussion of current and proposed studies and manuscripts; the HNRC Operations Workgroup, in which key managers and project coordinators address project implementation and troubleshooting, and the Human Subjects Committee, which monitors human subjects and IRB issues, particularly relating to safeguarding confidentiality. The structures and processes of the Core ensure the operation of a truly multidisciplinary research center and foster a wide-ranging nimbleness and responsiveness not only to priorities announced at the national level by policy (e.g., the NIH) and those expressed by the national neuroAIDS research community (e.g., our nation-  wide collaborating universities), but also within our home institution (HNRC scientific Core leaders, other UCSD HIV research groups).