PAHs: New Technologies and Emerging Health Risks

俄勒冈州立大学超级基金研究计划(SRP)是一个多研究者、多学科、多机构的项目。我们与太平洋西北国家实验室以及其他利益相关者和合作者合作，寻求开发新技术来评估在美国许多超级基金所在地发现的多环芳烃(PAHs)，并评估它们对人类健康构成的风险。SRP由三个生物医学研究项目、两个非生物医学研究项目、行政、研究翻译、社区参与、培训和两个研究支助核心(生物统计、建模和化学)组成。在该计划的未来五年中，将追求一些创新性和高影响力的研究目标，包括：(1)首次研究人类如何在环境暴露水平下摄取和排泄致癌多环芳烃；(2)为多环芳烃混合物的风险评估建立基于生理的药代动力学(PBPK)模型；(3)使用斑马鱼模型确定多环芳烃混合物和在环境中形成的多环芳烃的发育毒性；(4)使用被动采样设备来评估超级基金地点的生物可用多环芳烃以及补救策略的有效性；(5)采用新的分析方法评估超级基金地点土壤和沉积物中多环芳烃随时间的化学变化。核心将：(1)指导SRP的活动(行政)；(2)寻求有效的机制，向利益攸关方传播我们的研究结果(研究翻译)；(3)与受多环芳烃影响的社区合作，解决关切问题并寻求降低风险的解决方案(社区参与)；(4)为下一代环境健康科学家提供密集的多学科培训机会(培训)和；(5和6)为正在进行的研究的设计、进行和解释提供生物统计和建模支持，并使用最先进的化学仪器和方法来评估环境和生物基质中数百种多环芳烃的特性和数量。实现这些目标将带来重大的科学进步，并改善受影响社区的生活质量。

The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In partnership wit Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program a number of innovative and high impact research goals will be pursued including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure; (2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures; (3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model; (4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and; (5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative); (2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement); (4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and; (5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of the-art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matrices. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.