PAHs: New Technologies and Emerging Health Risks

PAH：新技术和新出现的健康风险

• 批准号: 8458260
• 负责人: David E Williams
• 金额: $ 311.73万
• 依托单位: OREGON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-27 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458260
• 关键词: Address; Aromatic Polycyclic Hydrocarbons; Bioavailable; Biological; Biomedical Research; Biostatistics Core; Burn injury; Chemicals; Chemistry; Coal; Communities; Development; Devices; Effectiveness; Environment; Environmental Health; Exposure to; Goals; Health; Human; Laboratories; Mediation; Modeling; Oregon; Pacific Northwest; Petroleum; Quality of life; Research; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk; Risk Assessment; Sampling; Scientist; Site; Solutions; Superfund; Time; Tobacco; Toxic effect; Training; Translational Research; Universities; Wit; Work; Zebrafish; base; design; improved; innovation; instrumentation; new technology; next generation; pharmacokinetic model; programs; remediation; superfund site

The Oregon State University Superfund Research Program (SRP) is multi-investigator, multi-disciplinary and multi-institutional. In partnership wit Pacific Northwest National Laboratories, and other stakeholders and collaborators, we seek to develop new technologies to assess polycyclic aromatic hydrocarbons (PAHs) found at many of the nation's Superfund sites and assess the risk they pose for human health. The SRP consists of three biomedical research projects, two non-biomedical research projects, Administrative, Research Translation, Community Engagement, Training and two research support cores (Biostatistics and Modeling and Chemistry). Over the next five years of the program a number of innovative and high impact research goals will be pursued including: (1) the first ever study of how humans take-up and excrete carcinogenic PAHs at environmental levels of exposure; (2) produce Physiologically Based Pharmacokinetic (PBPK) models for risk assessment of PAH mixtures; (3) determine developmental toxicities of PAH mixtures and PAHs formed in the environment using a zebrafish model; (4) employ passive sampling devices to assess bioavailable PAHs at Superfund sites and the effectiveness of remediation strategies and; (5) employ new analytical approaches to assessing chemical changes in PAHs in soilds and sediments at Superfund sites over time. The cores will: (1) direct the activities of the SRP (Administrative); (2) pursue effective mechanisms for disseminating our findings to stakeholders (Research Translation), (3) work with communities impacted by PAH exposure to address concerns and pursue solutions for reduced risk (Community Engagement); (4) provide intensive multi-disciplinary training opportunities for the next generation of Environmental Health Scientists (Training) and; (5 and 6) provide Biostatistical and Modeling support for the design, conduct and interpretation of the research being conducted as well as using state-of the-art Chemistry instrumentation and approaches to assess the identity and quantity of hundreds of PAHs found in environmental and biological matrices. Accomplishing these goals will provide significant scientific advancement and improve the quality of life for impacted communities.

俄勒冈州立大学超级基金研究项目（SRP）是一个多研究者、多学科、多机构的项目。我们与太平洋西北国家实验室以及其他利益攸关方和合作者合作，寻求开发新技术，以评估在国家许多超级基金遗址发现的多环芳烃（PAHs），并评估它们对人类健康构成的风险。SRP包括三个生物医学研究项目、两个非生物医学研究项目、行政、研究翻译、社区参与、培训和两个研究支持核心（生物统计学、建模和化学）。在接下来的五年里，该计划将追求一些创新和高影响力的研究目标，包括：(1)有史以来第一次研究人类如何在环境暴露水平下吸收和排泄致癌多环芳烃；(2)建立基于生理的药代动力学（PBPK）模型，用于多环芳烃混合物的风险评估；(3)利用斑马鱼模型确定多环芳烃混合物和环境中形成的多环芳烃的发育毒性；(4)采用被动采样装置评估超级基金场址的生物可利用多环芳烃及其修复策略的有效性；(5)采用新的分析方法评估超级基金场址固体和沉积物中多环芳烃的化学变化。核心将：(1)指导SRP（行政）的活动；(2)寻求将我们的发现传播给利益相关者的有效机制（研究翻译）；(3)与受多环芳烃暴露影响的社区合作，解决问题并寻求降低风险的解决方案（社区参与）；(4)为下一代环境卫生科学家（培训）提供密集的多学科培训机会；（5和6）为正在进行的研究的设计、进行和解释提供生物统计和建模支持，并使用最先进的化学仪器和方法来评估环境和生物基质中发现的数百种多环芳烃的特性和数量。实现这些目标将带来重大的科学进步，并改善受影响社区的生活质量。