Intergrative Health Sciences Core

综合健康科学核心

• 批准号: 8650855
• 负责人: Joel Daniel Kaufman
• 金额: $ 37.71万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8650855
• 关键词: Analytical Biochemistry; Animals; Area; Basic Science; Bioinformatics; Biological Markers; Biometry; Biostatistics Core; Chronic Disease; Clinical; Clinical Research; Collaborations; Consultations; Core Facility; Cytology; Data; Discipline; Ensure; Environmental Health; Environmental Risk Factor; Epidemiology; Epigenetic Process; Fostering; Genetic; Goals; Health Policy; Health Sciences; Histology; Human; Image; Immunohistochemistry; Interdisciplinary Study; Mass Spectrum Analysis; Metabolic; Mission; Molecular; Phenotype; Proteomics; Public Health; Recording of previous events; Research; Research Design; Research Personnel; Resources; Services; Systems Biology; Technology; Transgenic Animals; Translational Research; Universities; Washington; bench to bedside; cost; functional genomics; health practice; innovation; metabolomics; population based; research clinical testing; small molecule; virtual

The Integrative Environmental Health Sciences Facility Core (lEHSFC) serves the CEEH as a focal point for interdisciplinary research, the portal for accessing Center services, and a comprehensive consultation resource to assist CEEH investigators and trainees, emphasizing clinical, translational, and population-based studies. The lEHSFC allows UW EHS research to move as smoothly as possible not only from "bench-to-bedside" but also from population-based observations to bench to clinical research and onward to public health policy and practice. This facility core builds on a rich history of environmental health translational and epidemiological research at the UW. The lEHSFC facilitates EHS research¿including translational research~and fosters the integration of basic sciences research at the University of Washington with population-based and clinical EHS research. The core's mission is to provide access and consultation to CEEH investigators to ensure that the most modern molecular and 'systems biology' approaches are used to identify the interactions between genetic, epigenetic and environmental factors that contribute to the major chronic diseases. The core is comprised of three units: the Clinical/Translational Services Unit (CTSU), the Bioinformatics and Biostatistics Unit (BBU, this unit also includes OMICs integration), and the Technology Access Unit (TAU). The Bioinformatics and Biostatistics Unit provides many of the services that were previously provided by a dedicated Bioinformatics and Biostatistics Core. The other two units provide suites of services that are essentially new in this proposal. While the core offers a myriad of concrete services (and even a dedicated space for clinical evaluation in the CTSU), the core is first and foremost a literal and virtual collaborative space dedicated to encouraging and enabling innovative translational research and collaborations across disciplines at the UW.

综合环境健康科学设施核心（lEHSFC）服务于CEEH作为跨学科研究的焦点，访问中心服务的门户网站，以及全面的咨询资源，以帮助CEEH研究人员和学员，强调临床，转化和基于人口的研究。 lEHSFC允许UW EHS研究尽可能顺利地从“实验室到床边”，而且从基于人群的观察到实验室到临床研究，再到公共卫生政策和实践。该设施的核心是建立在环境卫生转化和流行病学的丰富历史基础上的 在UW的研究。lEHSFC促进EHS研究，包括转化研究，并促进华盛顿大学基础科学研究与基于人群和临床EHS研究的整合。核心的使命是为CEEH研究人员提供访问和咨询，以确保使用最现代的分子和“系统生物学”方法来确定导致主要慢性疾病的遗传，表观遗传和环境因素之间的相互作用。 核心由三个单位组成：临床/翻译服务单位（CTSU），生物信息学和生物统计学单位（BBU，该单位还包括OMIC整合）和技术访问单位（TAU）。生物信息学和生物统计学单位提供许多以前由专门的生物信息学和生物统计学核心提供的服务。另外两个单位提供的成套服务在本提案中基本上是新的。虽然核心提供了无数的具体服务（甚至是CTSU的临床评价专用空间），但核心首先是一个文字和虚拟的协作空间，致力于鼓励和实现跨学科的创新转化研究和协作 在UW。