SOLAir: Environmental Factors and Diabetes Development in Latinos

SOLAir：环境因素和拉丁美洲人的糖尿病发展

• 批准号: 10267202
• 负责人: Joel Daniel Kaufman
• 金额: $ 101.58万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267202
• 关键词: Accelerometer; Address; Adult; Affect; Air Pollutants; Air Pollution; Ancillary Study; Area; Benefits and Risks; Biological; Cardiovascular Diseases; Cause of Death; Characteristics; Clinical; Cluster Analysis; Cohort Studies; Communities; Data; Development; Diabetes Mellitus; Diet; Direct Costs; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Ethnic Origin; Exercise; Exposure to; Facilities and Administrative Costs; Funding; Genetic; Genetic Predisposition to Disease; Genomics; Genotype; Glycosylated hemoglobin A; Green space; Health; Health Food; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Hispanics; Incidence; Individual; Latino; Link; Location; Lung diseases; Measurement; Measures; Meta-Analysis; Metabolic; Metabolic Diseases; Methodology; Mission; Modeling; Modification; Monitor; Neighborhoods; Nitrogen Dioxide; Nitrogen Oxides; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Measure; Ozone; Participant; Particulate Matter; Phenotype; Physical activity; Play; Policies; Pollution; Population; Prediabetes syndrome; Prevalence; Psychosocial Factor; Public Health; Race; Relative Risks; Research; Resources; Risk; Risk Factors; Role; Series; Socioeconomic Status; Source; United States National Institutes of Health; Urban Population; Visceral; base; built environment; clinical examination; cohort; cost; cost effective; diabetes risk; fine particles; glycemic control; health disparity; health inequalities; high risk population; knowledge base; low socioeconomic status; metabolomics; metropolitan; mortality; multiple omics; protective factors; traffic-related air pollution; urban disparity; urban setting; walkability

Project Summary Diabetes mellitus is a major health problem; nearly half of adults in the U.S. have either diabetes or pre- diabetes. The link between adiposity and the development of Type 2 diabetes (T2DM) is well characterized, but less is known about the impact of environmental factors on risk of T2DM. Research increasingly implicates traffic-related air pollutants (TRAP) with increased risk of T2DM—especially in vulnerable urban populations, but studies thus far have wide ranges of results or have substantial methodological limitations. Other community-scale environmental factors, including aspects of the built and natural environment are also potential risk or protective factors for T2DM and may act through interactions with physical activity, diet and visceral adiposity. This study will incorporate state-of-the-art environmental exposure assessment with detailed health measures and data on potential confounders, including genetic susceptibility, to study these relationships---in a comprehensive framework—focusing on a fast-growing population at disproportionate risk of T2DM risk, through the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. HCHS/SOL provides a longitudinal assessment of glycemic control along with a broad range of clinical, anthropometric, and psychosocial factors, and begin a third comprehensive clinical exam in early 2020. This proposal adds a multi-dimensional environmental assessment to the HCHS/SOL cohort, effectively leveraging the planned examination and other funded ancillary studies. Through air pollution monitoring and modeling, accelerometry data, GPS logging, genetic cluster analysis, and advanced geostatistical approaches, the proposal takes advantage of extraordinary set of available resources to measure physical activity (amount and location), individual TRAP exposure, built environment features, genetic susceptibility, and health measures concurrently. The objective of “SOLAir” is a series of hypothesis-driven, policy-relevant analyses, to understand the environmental influences on T2DM, applying a theoretical framework that includes the interplay between environmental factors and physical activity. This proposal will address the following aims: 1) to assess whether long-term exposures to traffic-related air pollutants (TRAP) increase risk of pre-diabetes and T2DM among Latinos; 2) to determine how environmental factors interact with physical activity to influence T2DM risk; and 3) to examine whether environmental factors contribute differently to sub-types of T2DM identified by genetic clusters, phenotypic characteristics, and metabolomic features.

项目概要 糖尿病是一个主要的健康问题；美国近一半的成年人患有糖尿病或患有糖尿病 糖尿病。肥胖与 2 型糖尿病 (T2DM) 发展之间的联系已得到充分表征， 但人们对环境因素对 T2DM 风险的影响知之甚少。研究越来越表明 与交通相关的空气污染物（TRAP）会增加患 T2DM 的风险——尤其是在弱势城市人群中， 但迄今为止的研究已经取得了广泛的结果，或者存在很大的方法学局限性。其他 社区规模的环境因素，包括建筑和自然环境方面也 T2DM 的潜在风险或保护因素，可能通过体力活动、饮食和饮食的相互作用发挥作用。 内脏肥胖。这项研究将结合最先进的环境暴露评估和详细的 健康措施和潜在混杂因素的数据，包括遗传易感性，以研究这些 关系——在一个综合框架中——重点关注面临不成比例风险的快速增长的人口 通过西班牙裔社区健康研究/拉丁裔研究 (HCHS/SOL) 队列，了解 T2DM 风险。 HCHS/SOL 提供血糖控制的纵向评估以及广泛的临床、人体测量、 和心理社会因素，并于 2020 年初开始第三次综合临床检查。该提案增加了 对 HCHS/SOL 队列进行多维环境评估，有效利用计划 考试和其他资助的辅助研究。通过空气污染监测和建模、加速度测量 该提案采用了数据、GPS 记录、遗传聚类分析和先进的地统计方法 利用大量可用资源来衡量身体活动（数量和地点）， 个人 TRAP 暴露、建筑环境特征、遗传易感性和健康措施 同时。 “SOLAir”的目标是一系列假设驱动的、与政策相关的分析，以 应用包括相互作用在内的理论框架，了解环境对 T2DM 的影响 环境因素和体力活动之间的关系。 该提案将实现以下目标：1）评估是否长期暴露于与交通相关的空气中 污染物 (TRAP) 增加拉丁裔患糖尿病前期和 T2DM 的风险； 2）确定环境如何 与体力活动相互作用的因素会影响 T2DM 风险； 3）检查环境因素是否 通过遗传簇、表型特征和特征对 T2DM 亚型的贡献不同 代谢组学特征。