SOLAir: Environmental Factors and Diabetes Development in Latinos

SOLAir：环境因素和拉丁美洲人的糖尿病发展

• 批准号: 10267202
• 负责人: Joel Daniel Kaufman
• 金额: $ 101.58万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-22 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267202
• 关键词: Accelerometer; Address; Adult; Affect; Air Pollutants; Air Pollution; Ancillary Study; Area; Benefits and Risks; Biological; Cardiovascular Diseases; Cause of Death; Characteristics; Clinical; Cluster Analysis; Cohort Studies; Communities; Data; Development; Diabetes Mellitus; Diet; Direct Costs; Environment; Environmental Exposure; Environmental Impact; Environmental Risk Factor; Ethnic Origin; Exercise; Exposure to; Facilities and Administrative Costs; Funding; Genetic; Genetic Predisposition to Disease; Genomics; Genotype; Glycosylated hemoglobin A; Green space; Health; Health Food; Heterogeneity; Hispanic Community Health Study/Study of Latinos; Hispanics; Incidence; Individual; Latino; Link; Location; Lung diseases; Measurement; Measures; Meta-Analysis; Metabolic; Metabolic Diseases; Methodology; Mission; Modeling; Modification; Monitor; Neighborhoods; Nitrogen Dioxide; Nitrogen Oxides; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome Measure; Ozone; Participant; Particulate Matter; Phenotype; Physical activity; Play; Policies; Pollution; Population; Prediabetes syndrome; Prevalence; Psychosocial Factor; Public Health; Race; Relative Risks; Research; Resources; Risk; Risk Factors; Role; Series; Socioeconomic Status; Source; United States National Institutes of Health; Urban Population; Visceral; base; built environment; clinical examination; cohort; cost; cost effective; diabetes risk; fine particles; glycemic control; health disparity; health inequalities; high risk population; knowledge base; low socioeconomic status; metabolomics; metropolitan; mortality; multiple omics; protective factors; traffic-related air pollution; urban disparity; urban setting; walkability

Project Summary Diabetes mellitus is a major health problem; nearly half of adults in the U.S. have either diabetes or pre- diabetes. The link between adiposity and the development of Type 2 diabetes (T2DM) is well characterized, but less is known about the impact of environmental factors on risk of T2DM. Research increasingly implicates traffic-related air pollutants (TRAP) with increased risk of T2DM—especially in vulnerable urban populations, but studies thus far have wide ranges of results or have substantial methodological limitations. Other community-scale environmental factors, including aspects of the built and natural environment are also potential risk or protective factors for T2DM and may act through interactions with physical activity, diet and visceral adiposity. This study will incorporate state-of-the-art environmental exposure assessment with detailed health measures and data on potential confounders, including genetic susceptibility, to study these relationships---in a comprehensive framework—focusing on a fast-growing population at disproportionate risk of T2DM risk, through the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. HCHS/SOL provides a longitudinal assessment of glycemic control along with a broad range of clinical, anthropometric, and psychosocial factors, and begin a third comprehensive clinical exam in early 2020. This proposal adds a multi-dimensional environmental assessment to the HCHS/SOL cohort, effectively leveraging the planned examination and other funded ancillary studies. Through air pollution monitoring and modeling, accelerometry data, GPS logging, genetic cluster analysis, and advanced geostatistical approaches, the proposal takes advantage of extraordinary set of available resources to measure physical activity (amount and location), individual TRAP exposure, built environment features, genetic susceptibility, and health measures concurrently. The objective of “SOLAir” is a series of hypothesis-driven, policy-relevant analyses, to understand the environmental influences on T2DM, applying a theoretical framework that includes the interplay between environmental factors and physical activity. This proposal will address the following aims: 1) to assess whether long-term exposures to traffic-related air pollutants (TRAP) increase risk of pre-diabetes and T2DM among Latinos; 2) to determine how environmental factors interact with physical activity to influence T2DM risk; and 3) to examine whether environmental factors contribute differently to sub-types of T2DM identified by genetic clusters, phenotypic characteristics, and metabolomic features.

项目摘要 糖尿病是主要的健康问题。在美国，几乎一半的成年人患有糖尿病或前 糖尿病。肥胖与2型糖尿病（T2DM）的发展之间的联系是很好的特征， 但是，对环境因素对T2DM风险的影响知之甚少。研究越来越含义 与交通相关的空气污染物（TRAP），T2DM风险增加，尤其是在脆弱的城市人口中， 但是迄今为止的研究具有广泛的结果或具有实质性的方法论局限性。其他 社区规模的环境因素，包括建筑和自然环境的各个方面 T2DM的潜在风险或受保护因素，并可能通过与体育锻炼，饮食和 内脏肥胖。这项研究将结合最新的环境暴露评估 有关潜在混杂因素（包括遗传易感性）的健康测量和数据，以研究这些问题 人际关系---在一个全面的框架中 - 将快速增长的人口关注不成比例的风险 T2DM风险，通过西班牙裔社区健康研究/拉丁裔（HCHS/SOL）队列研究。 HCHS/SOL 提供对血糖控制的纵向评估以及广泛的临床，人体测量法 和社会心理因素，并于2020年初开始第三次全面临床检查。该提案增加了 对HCHS/SOL队列的多维环境评估，有效地利用了计划的 检查和其他基本辅助研究。通过空气污染监测和建模，加速度测定法 数据，GPS日志记录，遗传聚类分析和高级地统计方法，该提案采用 优势是一组可用资源以衡量体育活动（数量和位置）的优势， 单个陷阱暴露，建筑环境特征，遗传敏感性和健康措施 “ Solair”的目的是一系列由假设驱动的，与政策相关的分析，用于 了解环境对T2DM的影响，应用包括相互作用的理论框架 在环境因素和体育活动之间。 该提案将解决以下目的：1）评估是否长期暴露于交通相关的空气 污染物（陷阱）增加了拉丁美洲裔糖尿病前的风险和T2DM的风险； 2）确定环境 因素与体育活动相互作用以影响T2DM风险； 3）检查环境因素是否 对通过遗传簇，表型特征和 代谢组特征。