Symposium on Air Pollution and Cardiovascular Disease

描述（由申请人提供）：本申请寻求对第五届“空气污染与心血管疾病”研讨会的支持。这次会议将提供一个科学论坛，介绍有关空气污染物对心血管影响的最新研究结果。本次研讨会将汇集该地区的主要研究人员，并促进与空气污染影响血管疾病的性质，进展和触发机制相关领域的互动和关键讨论。研讨会将于2010年在华盛顿大学举行。参与者将包括来自美国公立和私立大学的研究人员，他们积极参与这一研究或相关调查。本次会议的目标是共同确定与环境污染物对心血管影响有关的问题的性质和范围。虽然广泛的流行病学研究表明污染与心脏病之间存在联系，但尚不清楚如何在相关实验室模型中重新检查流行病学数据，以及如何在机械基础上研究污染物对心血管的影响以建立因果关系。因此，本次会议的主要目标是提供一个有凝聚力的论坛，介绍，评估和讨论了解污染物对心血管健康影响的最新方法。第一天将有相关的主题评论以及活跃实验室的最新发现。第二天将强调就基本机制和今后研究的富有成果的领域建立共识。会议将涵盖的主题涵盖了心血管效应的全方位，从人类和流行病学研究到环境污染物影响心血管疾病的分子和细胞效应，重点是就潜在毒性机制和未来研究的关键方向达成共识。该计划将以国际公认的领导人和来自美国的有才华的新调查人员为特色。 公共卫生相关性：心血管疾病是死亡的主要原因，空气污染物是心血管疾病的普遍和非自愿的潜在危险因素。这次会议将提供一个科学论坛，介绍有关空气污染物对心血管影响的最新研究结果。本次研讨会将汇集该地区的主要研究人员，并促进与空气污染影响血管疾病的性质，进展和触发机制相关领域的互动和关键讨论。

DESCRIPTION (provided by applicant): This application seeks support for the fifth symposium on "Air Pollution and Cardiovascular Disease". This meeting will provide a scientific forum for presenting recent findings related to the cardiovascular effects of air pollutants. This symposium will bring together leading investigators in the area and facilitate interactions and critical discussion in areas related to the mechanisms by which air pollution affects the nature, progression and triggering of vascular diseases. The symposium will be held at the University of Washington in 2010. The participants will include investigators from public and private universities in the US who are actively involved in research in this or a related line of investigation. The goal of this meeting is to collectively define the nature and the scope of the problem related to the cardiovascular effects of environmental pollutants. Although extensive epidemiological studies demonstrate a link between pollution and heart disease, it is unclear how the epidemiological data could be re- examined in relevant laboratory models, and how the cardiovascular effects of pollutants could be studied on a mechanistic basis to establish cause-and-effect relationships. Hence, the major goal of this meeting is to provide a cohesive forum for presenting, evaluating and discussing the latest approaches to understanding the effects of pollutants on cardiovascular health. The first day will feature relevant topic reviews as well as the latest findings from active laboratories. The second day will emphasize consensus-building on underlying mechanisms and fruitful areas for future research. The topics to be covered at the conference span the full spectrum of cardiovascular effects ranging from human and epidemiological studies to molecular and cellular effects by which environmental pollutants affect cardiovascular disease, with a focus on building a consensus on mechanisms underlying toxicity and key future directions for research. The program will feature internationally recognized leaders and talented new investigators from the United States. PUBLIC HEALTH RELEVANCE: Cardiovascular diseases are the leading cause of mortality, and air pollutants pose a ubiquitous and involuntary potential risk factor for cardiovascular disease. This meeting will provide a scientific forum for presenting recent findings related to the cardiovascular effects of air pollutants. This symposium will bring together leading investigators in the area and facilitate interactions and critical discussion in areas related to the mechanisms by which air pollution affects the nature, progression and triggering of vascular diseases.