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SOLAir: Environmental Factors and Diabetes Development in Latinos

SOLAir：环境因素和拉丁美洲人的糖尿病发展

基本信息

批准号：
10466946
负责人：
Joel Daniel Kaufman
金额：
$ 82.17万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-22 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10466946
关键词：
Accelerometer Address Adult Affect Air Pollutants Air Pollution Ancillary Study Area Benefits and Risks Biological Cardiovascular Diseases Cause of Death Characteristics Clinical Cluster Analysis Cohort Studies Communities Data Development Diabetes Mellitus Diet Direct Costs Environment Environmental Exposure Environmental Impact Environmental Risk Factor Ethnic Origin Exercise Exposure to Facilities and Administrative Costs Funding Genetic Genetic Predisposition to Disease Genomics Genotype Glycosylated hemoglobin A Green space Health Health Food Heterogeneity Hispanic Hispanic Community Health Study/Study of Latinos Incidence Individual Latino Population Link Location Measurement Measures Meta-Analysis Metabolic Metabolic Diseases Methodology Mission Modeling Modification Monitor Neighborhoods Nitrogen Dioxide Nitrogen Oxides Non-Insulin-Dependent Diabetes Mellitus Obesity Outcome Measure Ozone Participant Particulate Matter Persons Phenotype Physical activity Play Policies Pollution Population Prediabetes syndrome Prevalence Psychosocial Factor Public Health Race Relative Risks Research Resources Respiratory Disease Risk Risk Factors Role Series Socioeconomic Status Source United States National Institutes of Health Urban Population Visceral base built environment clinical examination cohort cost cost effective diabetes risk fine particles glycemic control health disparity health inequalities high risk population knowledge base low socioeconomic status metabolomics metropolitan mortality multiple omics protective factors traffic-related air pollution urban disparity urban setting walkability

项目摘要

Project Summary Diabetes mellitus is a major health problem; nearly half of adults in the U.S. have either diabetes or pre- diabetes. The link between adiposity and the development of Type 2 diabetes (T2DM) is well characterized, but less is known about the impact of environmental factors on risk of T2DM. Research increasingly implicates traffic-related air pollutants (TRAP) with increased risk of T2DM—especially in vulnerable urban populations, but studies thus far have wide ranges of results or have substantial methodological limitations. Other community-scale environmental factors, including aspects of the built and natural environment are also potential risk or protective factors for T2DM and may act through interactions with physical activity, diet and visceral adiposity. This study will incorporate state-of-the-art environmental exposure assessment with detailed health measures and data on potential confounders, including genetic susceptibility, to study these relationships---in a comprehensive framework—focusing on a fast-growing population at disproportionate risk of T2DM risk, through the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. HCHS/SOL provides a longitudinal assessment of glycemic control along with a broad range of clinical, anthropometric, and psychosocial factors, and begin a third comprehensive clinical exam in early 2020. This proposal adds a multi-dimensional environmental assessment to the HCHS/SOL cohort, effectively leveraging the planned examination and other funded ancillary studies. Through air pollution monitoring and modeling, accelerometry data, GPS logging, genetic cluster analysis, and advanced geostatistical approaches, the proposal takes advantage of extraordinary set of available resources to measure physical activity (amount and location), individual TRAP exposure, built environment features, genetic susceptibility, and health measures concurrently. The objective of “SOLAir” is a series of hypothesis-driven, policy-relevant analyses, to understand the environmental influences on T2DM, applying a theoretical framework that includes the interplay between environmental factors and physical activity. This proposal will address the following aims: 1) to assess whether long-term exposures to traffic-related air pollutants (TRAP) increase risk of pre-diabetes and T2DM among Latinos; 2) to determine how environmental factors interact with physical activity to influence T2DM risk; and 3) to examine whether environmental factors contribute differently to sub-types of T2DM identified by genetic clusters, phenotypic characteristics, and metabolomic features.

项目总结