Life course contexts and work - quantifying impacts on aging and chronic disease

生命历程背景和工作 - 量化对衰老和慢性病的影响

• 批准号: 8680064
• 负责人: David H Rehkopf
• 金额: $ 12.65万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8680064
• 关键词: Age; Aging; Area; Characteristics; Chronic; Chronic Disease; Data; Data Collection; Disease; Documentation; Elderly; Employee; Environment; Epidemiologic Methods; Etiology; Future; Goals; Health; Hour; Individual; K-Series Research Career Programs; Life; Life Cycle Stages; Life Expectancy; Link; Location; Measurable; Medical; Medicare; Mentors; Mentorship; Modeling; Motivation; Outcomes Research; Process; Recording of previous events; Records; Research; Research Methodology; Research Personnel; Retirement; Role; Social Environment; Socioeconomic Status; Staging; Testing; Training; United States; Variant; Work; Workplace; aging population; career; career development; cohort; disorder risk; experience; follow-up; healthy aging; improved; middle age; novel; population health; public health relevance; skills; social health determinants; socioeconomics; trend

DESCRIPTION (provided by applicant): While chronic conditions often first present clinically at older ages, their etiology begins much earlier. It is instead during mid-life, and potentially before, that these diseases have their origins. One critical but not well understood environment where most individuals spend the majority of their waking hours during mid-life is the workplace. It is therefore essential that we examine the potential impacts of the work environment on chronic conditions of aging in order to improve health at older ages. Some of the proximal negative health impacts of the workplace have already been documented, but how they may impact health many years later is not well understood. It is also critical that work environment be studied within a broader life course continuum of pre- work environment and post-work environment. Due in part to the absence of data that links the broader environment, work environment and chronic conditions over multiple stages of life, the potential importance of these impacts on health are unclear. My goal for this career development award is to obtain mentoring and training that will allow me to establish myself as an independent researcher focused on understanding the impacts of the workplace on aging and chronic disease. I have developed a project that will build on both my new training and my current expertise in social determinants of health research and epidemiologic methods to examine how the workplace environment, situated within a life course context, impacts aging and chronic disease. I have proposed three areas of focused training and mentoring to be able to accomplish my proposed project and achieve my long term career goals: 1) work and health, 2) aging across the life course and 3) demographic life stage analysis. The specific aims will be achieved using a unique collection of data that has been assembled for approximately 40,000 Alcoa employees. This cohort is the best data for achieving these aims because: 1) there is detailed data on work environment, and substantial variation in work environment across 48 different locations, 2) we are able to fully link working and later life health to early life environment, and 3) we are able o link to complete medical claims records over their entire work history with additional linkage to Medicare records for long-term follow-up. The specific aims are as follows, Aim 1: Quantify the contribution of specific aspects of the workplace environment to aging and chronic disease, Aim 2: Quantify the contributions of early life context, working life context and retirement context to aging and chronic disease, and Aim 3: Use demographic life stage analysis to quantify the future potential impacts of early life context, working life context and retirement context on chronic disease. The expected outcomes of the research component of this career development award are that aims 1 and 2 will identify novel factors associated with aging and chronic disease, and aim 3 will examine the potential role of these factors on future trends in aging and chronic disease.

描述（由申请人提供）：虽然慢性疾病通常在老年时首次出现临床症状，但其病因开始得更早。相反，这些疾病的起源是在中年，甚至可能在中年之前。一个关键但不太清楚的环境是工作场所，大多数人在中年期间花费了大部分清醒时间。因此，我们必须研究工作环境对老年慢性病的潜在影响，以改善老年人的健康状况。工作场所的一些近期负面健康影响已经有了记录，但它们如何在多年后影响健康还没有得到很好的理解。同样重要的是， 在工作前和工作后环境的更广泛的生命过程连续体中进行研究。部分由于缺乏数据将更广泛的环境、工作环境和生命多个阶段的慢性病联系起来，这些影响对健康的潜在重要性尚不清楚。我获得这个职业发展奖的目标是获得指导和培训，使我能够成为一名独立的研究人员，专注于了解工作场所对衰老和慢性病的影响。我已经开发了一个项目，将建立在我的新的培训和我目前在健康研究和流行病学方法的社会决定因素的专业知识，以研究如何工作场所的环境，位于生命历程的背景下，影响衰老和慢性病。我提出了三个重点培训和指导领域，以便能够完成我提出的项目并实现我的长期职业目标：1）工作和健康，2）整个生命过程中的老龄化和3）人口生命阶段分析。具体目标将通过收集约40，000名Alcoa员工的独特数据来实现。该队列是实现这些目标的最佳数据，因为：1）有关于工作环境的详细数据，48个不同地点的工作环境存在很大差异，2）我们能够将工作和晚年健康与早期生活环境完全联系起来，和3）我们能够链接到完整的医疗索赔记录在他们的整个工作历史与额外的链接到医疗保险记录长期-长期随访。具体目标如下：目标1：量化工作场所环境的具体方面对老龄化和慢性病的贡献，目标2：量化早年生活背景、工作生活背景和退休背景对老龄化和慢性病的贡献。 目标3：使用人口生命阶段分析来量化早期生活背景、工作生活背景和退休背景对慢性病的未来潜在影响。该职业发展奖的研究部分的预期成果是，目标1和2将确定与衰老和慢性病相关的新因素，目标3将研究这些因素对衰老和慢性病未来趋势的潜在作用。