Research and Methods Core

研究和方法核心：项目摘要 我们建议的上游研究中心的重点是研究收入干预的影响 在持续贫困地区减少癌症长期负担的计划。我们为实现这一目标而提出的建议 是通过一个科学和协作的过程，优先考虑重叠的和不同的需求， 圣克拉拉县和约洛市持续贫困地区的拉丁裔和越南人社区 加利福尼亚州县。这种方法的基本原理是，有强有力的证据支持一个根本原因， 预防癌症的方法-也就是说，只有通过干预“原因的原因”，我们才能 在减少持续贫困地区的癌症负担方面取得实质性进展。我们不能仅仅依靠 单独进行个人或群体行为改变干预以减少癌症负担;我们 必须“逆流而上”。研究与方法核心将通过以下方式支持这一使命：目标1。协调 数据收集、措施和方法，并确保定量和定性数据的互操作性 中心内和中心之间的数据，目标2。项目干预措施的长期影响建模 和其他暴露对结直肠癌发病率的影响，目标3。与项目和核心协调， 以最有利于社区的方式与持续贫困社区建立数据仪表板和见解 在癌症预防方面采取行动，目标4。评估该中心的研究生产力和影响， 融资期。研究和方法核心将通过以下方式满足研究项目的需求： 协调研究项目中类似措施的收集，以便能够推断出 不同收入干预方案的价值，与项目调查人员合作， 推理的方法，并与项目调查人员协调， 他们的分析数据为基础的模型输入的数学模型，将预测人口水平的变化 在持续贫困地区的结直肠癌发病率。在上述所有过程中，研究和 方法核心将评估该中心的研究生产力和影响在资助期间的一部分， 领导团队的目标在行政核心中概述。研究和方法核心的使命是 受两个相互交织的预期影响领域的推动-- 1）关于地球物理学的强大和可重复的科学发现， 收入干预措施对预防持续贫困地区癌症的影响， 在这些领域开展癌症预防研究的能力。我们的团队将这些视为不可分割的目标。 尽管有令人信服的证据表明，解决健康问题的社会决定因素是一项根本性的工作， 疾病的原因，这项工作很少基于实际的干预和行动， 与癌症发病率有关。为了在持续贫困地区建立预防能力， 研究需要与这些社区共同进行，以便产生最大的影响， 研究与方法核心将在我们中心的这一使命中发挥作用。

Research and Methods Core: Project Summary The focus of our proposed UPSTREAM Research Center is examining the impacts of income intervention programs for reducing the long-term burden of cancer in persistent poverty areas. Our proposal to achieve this is through a scientific and collaborative process that prioritizes both the overlapping and also distinct needs of the Latino and Vietnamese communities in the persistent poverty areas of Santa Clara County and Yolo County, CA. The rationale for this approach is that there is robust evidence supporting a fundamental causes approach to cancer prevention – that is, only through intervening on the “causes of the causes” will we make substantial progress in reducing the cancer burden in persistent poverty areas. We cannot rely solely on individual or group behavioral change interventions alone for population reductions in the cancer burden; we must move ‘upstream’. The Research & Methods Core will support this mission through: Aim 1. Coordinating data collection, measures and methods and ensuring the interoperability of both quantitative and qualitative data within the Center and between Centers, Aim 2. Modeling the long-term effects of the project interventions and other exposures on colorectal cancer incidence, Aim 3. Coordinating with the projects and Cores to create data dashboards and insights with the persistent poverty communities in ways that will most benefit community led actions in cancer prevention, Aim 4. Evaluating the Center’s research productivity and impact over the funding period. The Research and Methods Core will address the needs of the Research projects by coordinating the collection of similar measures across research projects to enable inference as to the relative value of different income intervention programs, working with project investigators to coordinate methodological approaches for inference, and coordinating with project investigators to use estimates from their analytic data based models for inputs to a mathematical model that will predict population level changes in colorectal cancer incidence in persistent poverty areas. Across all of the above processes, the Research & Methods Core will evaluate the Center’s research productivity and impact over the funding period as part of the leadership team aims outlined in the Administrative Core. The mission of the Research and Methods Core is driven by two intertwining areas of intended impact – 1) robust and reproducible scientific discovery on the impact of income interventions on preventing cancer in persistent poverty areas in combination with 2) building capacity for cancer prevention research in those areas. Our team sees these as inseparable objectives. Despite the compelling evidence for the impact of addressing social determinants of health as fundamental causes of disease, less of this work has been based on actual interventions and actions, and even less of this work in relation to cancer incidence. To build capacity for prevention in persistent poverty areas, this scientific research needs to be co-produced with these communities in order to have the greatest impact, and the Research & Methods Core will play a part in this mission of our Center.