PHYSIOLOGY Core

Scripps NeuroAIDS临床前研究中心（SNAPS）的化学库筛选核心将 促进在与神经艾滋病相关的研究背景下筛选不同的化学文库。 TSRI的许多研究人员已经生成了库，并渴望与 生物学家/生物化学家致力于定义的生物系统。拟议核心的主要使命将 通过开发一系列高通量筛选来促进这种相互作用， 根据需要开发专门的屏幕。生物化学和基于细胞的筛选分析 将被开发并用于鉴定干扰病毒蛋白质的化合物的离散混合物 发挥作用并中断病毒生命周期和/或病毒对CNS的渗透。文库筛选核心 我将与一个非常多样化的调查小组互动，整合他们的专业知识，创造更多的 筛选化合物的专有技术。最终目标是帮助识别特定的铅 化合物，以帮助开发对神经艾滋病有效的抗病毒药物。

The Chem Library Screening Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS) Center will facilitate the screening of diverse chemical libraries in the context of research relevant to neuroAIDS. Numerous investigators at TSRI have generated libraries and are eager to collaborate with biologists/biochemists working on defined biological systems. The major mission of the proposed Core will be to facilitate such interactions by development of a series of high through-put screens and aid in the development of specialized screens as the need arises. Both biochemical and cell-based screening assays will be developed and employed to identify discrete mixtures of compounds that interfere with viral protein function(s) and interrupt the virus life cycle and/or virus penetration of the CNS. The Library Screening Core will interact with a very diverse group of investigators, integrating their expertise and creating additional know-how for the screening of compounds. The ultimate goal will be to aid in identification of specific lead compounds to aid in development of anti-virals effective against Neuro-AIDS.