Systems Biology & Integrative Networks Core

斯克里普斯神经艾滋病临床前研究(SNAPS)是一个支持生物医学的多学科中心 与神经艾滋病相关的研究。 在HIV感染中，HIV-1相关的认知/运动障碍，也称为艾滋病痴呆症复合体 或神经艾滋病，发生在大约三分之一的患者中。症状包括一种“轻微”障碍， 影响25%的人，到痴呆症，影响到15%到20%的艾滋病患者。虽然是最近的 治疗方面的进步已经降低了艾滋病毒的死亡率，这些药物中的大多数并没有显示出显著的 血脑屏障(BBS)的穿透。中枢神经系统(CNS)可能仍然是一个储存库 并且在治疗过程中遭受持续的损害--延长了感染病程。 HIV诱导的中枢神经系统改变的病因尚不清楚。我们的一个有效假设是病毒 大脑感染，通过受感染的巨噬细胞运输到 大脑启动了一系列导致神经元功能障碍的事件。然而，我们认为神经元，在 至少在早期，它们不会被病毒诱导的病理性级联不可逆转地破坏。因此，艾滋病毒诱导的中枢神经系统 损伤可能需要及时治疗，以防止中枢神经系统功能障碍的慢性后果。 利用多系统方法，SNAPS中心的研究旨在调查宿主和病毒因素 导致中枢神经系统功能障碍，并研究预防或改善这些不良影响的方法。这个 SNAPS中心汇集了来自蛋白质组、基因组和生理学的不同专业知识的科学家。 系统生物学和综合网络核心(SBINC)旨在开发一套生物信息学工具 用于使用复杂查询系统从分子相互作用网络中提取路径模型。 因为数据库查询是从大型生物信息学中提取信息的成熟方法 数据库，它可以作为一个关键概念来带来复杂的网络操作，如路径 建筑和仿真，以快照中心为中心。从而帮助科学家们更好地 查询他们的大型高吞吐量数据集，并利用集成系统方法更好地表征 这种复杂的神经病理。

The Scripps NeuroAIDS Preclinical Studies (SNAPS) is a multidisciplinary center supporting biomedical research relevant to neuroAIDS. In HIV infection, the HIV-1 -associated cognitive/motor disorder, also known as the AIDS dementia complex or neuroAIDS, occurs in approximately one-third of patients. Symptoms range from a "minor" disorder, affecting 25% of individuals, to dementia, affecting 15 to 20% of those with AIDS. Although recent therapeutic advances have reduced mortality from HIV, most of these agents do not show significant penetration of the blood-brain barrier (BBS). The central nervous system (CNS) may remain a reservoir as well as suffer continued damage over the treatment-prolonged course of infection. The etiology of the HIV-induced CNS alterations is unknown. One of our working hypotheses are that viral infection of the brain, occurring via a "Trojan horse" mechanism of infected macrophages trafficking to the brain initiates a sequence of events leading to neuronal dysfunction. However we believe that neurons, at least early, are not irreversibly damaged by a virus-induced pathological cascade. Thus HIV-induced CNS damage may be amenable to timely therapy to prevent the chronic consequence of CNS dysfunction. Using a multisystem approaches, the SNAPS center research aims to investigate the host and viral factors leading to CNS dysfunction, and investigate ways to prevent or ameliorate these untoward effects. The SNAPS center brings together scientists with different expertise from proteomic, genomic and physiology. The Systems Biology and Integrative Network Core (SBINC) aims to develop a suite of bioinformatics tools for extracting pathway models from molecular interaction networks using a system of complex queries. Because the database query is a well-established means of extracting information from large bioinformatics databases, it may serve as a key concept for bringing complex network operations, such as pathway construction and simulation, to the SNAPS center at large. Thus helping the SNAPS scientists to better query their large highthroughput dataset and to utilize a integrative system approach to better characterize this complex neuropathology.