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Relationships between air pollutants and asthma exacerbations in a birth cohort

出生队列中空气污染物与哮喘恶化之间的关系

基本信息

批准号：
8660693
负责人：
MATTHEW J. STRICKLAND
金额：
$ 12.82万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-10 至 2016-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In utero and early life experiences affect physiological development and can influence sensitivity to environmental factors throughout life. Data on early life risk factors, however, are typically not available to investigators who study associations between ambient air pollutant concentrations and pediatric asthma exacerbations. In the state of Georgia, birth records (1994-2007) have been linked with pediatric emergency department visits (2002-2007) by staff at the Georgia Department of Human Resources. This novel linkage between 1.8 million birth records and 5.5 million pediatric emergency department visits will be used to investigate whether children who were born premature or low birth weight are more sensitive to ambient air pollutant concentrations than their counterparts. If effect modification by gestational age or birth weight is observed, then these findings will help inform public health policy decisions, since protection of sensitive subgroups is central to EPA's mission as a regulatory agency. Further, within Metropolitan Atlanta, a research air quality monitoring station provides daily concentrations for a comprehensive suite of components of particulate matter less than 2.5 microns in diameter, a resource also not typically available to investigators. These measurements can be used to distinguish among the various compounds that comprise particulate matter less than 2.5 microns in diameter, and the proposed study will be the first to investigate associations between these compounds and pediatric emergency department visits in a birth cohort. Complex interactions between ambient air pollutants and airborne pollens on pediatric asthma exacerbations will be investigated using an innovative modeling approach based on two- dimensional loess smoothers in the framework of generalized additive models. Ambient air pollutants are known to cause asthma exacerbations in children. To inform public health policy decisions it is important to know whether certain subgroups of asthmatic children have increased susceptibility to air pollutants, and the proposed study will be the first to investigate whether children who were born premature or low birth weight have an increased susceptibility to air pollution.

描述（由申请人提供）：子宫内和早期生活经历会影响生理发育，并可能影响一生对环境因素的敏感性。然而，研究环境空气污染物浓度与儿童哮喘恶化之间关联的研究人员通常无法获得有关早期生命危险因素的数据。在佐治亚州，出生记录（1994-2007 年）已与佐治亚州人力资源部工作人员的儿科急诊科就诊（2002-2007 年）联系起来。 180 万份出生记录和 550 万份儿科急诊就诊之间的这种新颖联系将用于调查早产或低出生体重的儿童是否比同龄儿童对环境空气污染物浓度更敏感。如果观察到孕龄或出生体重对效应的影响，那么这些发现将有助于为公共卫生政策决策提供信息，因为保护敏感亚群体是 EPA 作为监管机构的使命的核心。此外，在亚特兰大大都会内，一个研究空气质量监测站提供直径小于 2.5 微米的全套颗粒物成分的每日浓度，而调查人员通常也无法获得这一资源。这些测量结果可用于区分直径小于 2.5 微米颗粒物的各种化合物，并且拟议的研究将是第一个调查这些化合物与出生队列中儿科急诊就诊之间的关联的研究。将使用基于广义相加模型框架中的二维黄土平滑器的创新建模方法来研究环境空气污染物和空气中花粉之间的复杂相互作用对儿童哮喘恶化的影响。众所周知，环境空气污染物会导致儿童哮喘恶化。为了为公共卫生政策决策提供信息，重要的是要了解某些哮喘儿童亚群是否对空气污染物的易感性增加，而拟议的研究将是第一个调查早产或低出生体重的儿童是否对空气污染的易感性增加的研究。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Pediatric Emergency Visits and Short-Term Changes in PM2.5 Concentrations in the U.S. State of Georgia.

DOI：
10.1289/ehp.1509856
发表时间：
2016-05
期刊：
Environmental health perspectives
影响因子：
10.4
作者：
Strickland MJ;Hao H;Hu X;Chang HH;Darrow LA;Liu Y
通讯作者：
Liu Y

Impact of exposure measurement error in air pollution epidemiology: effect of error type in time-series studies.

DOI：
10.1186/1476-069x-10-61
发表时间：
2011-06-22
期刊：
Environmental health : a global access science source
影响因子：
0
作者：
Goldman GT;Mulholland JA;Russell AG;Strickland MJ;Klein M;Waller LA;Tolbert PE
通讯作者：
Tolbert PE

Ciguatera fish poisoning and climate change: analysis of National Poison Center Data in the United States, 2001-2011.

Ciguatera鱼中毒和气候变化：2001 - 2011年美国国家毒物中心数据的分析。