Relationships between air pollutants and asthma exacerbations in a birth cohort
出生队列中空气污染物与哮喘恶化之间的关系
基本信息
- 批准号:8660693
- 负责人:
- 金额:$ 12.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-09-10 至 2016-04-30
- 项目状态:已结题
- 来源:
- 关键词:Accident and Emergency departmentAffectAirAir PollutantsAir PollutionAsthmaBirthBirth RecordsBirth WeightBronchiolitisCaliberCharacteristicsChildChildhoodChildhood AsthmaComplexDataDevelopmentEnvironmental Risk FactorGestational AgeHealth PolicyHuman ResourcesInfantLifeLife ExperienceLinkLow Birth Weight InfantMeasurementMissionModelingModificationMonitorParticulate MatterPhysiologicalPollenPredispositionPublic HealthResearchResearch PersonnelResourcesRisk FactorsSubgroupVisitbasecohortin uteroinnovationmetropolitannovelprematuretwo-dimensional
项目摘要
DESCRIPTION (provided by applicant): In utero and early life experiences affect physiological development and can influence sensitivity to environmental factors throughout life. Data on early life risk factors, however, are typically not available to investigators who study associations between ambient air pollutant concentrations and pediatric asthma exacerbations. In the state of Georgia, birth records (1994-2007) have been linked with pediatric emergency department visits (2002-2007) by staff at the Georgia Department of Human Resources. This novel linkage between 1.8 million birth records and 5.5 million pediatric emergency department visits will be used to investigate whether children who were born premature or low birth weight are more sensitive to ambient air pollutant concentrations than their counterparts. If effect modification by gestational age or birth weight is observed, then these findings will help inform public health policy decisions, since protection of sensitive subgroups is central to EPA's mission as a regulatory agency. Further, within Metropolitan Atlanta, a research air quality monitoring station provides daily concentrations for a comprehensive suite of components of particulate matter less than 2.5 microns in diameter, a resource also not typically available to investigators. These measurements can be used to distinguish among the various compounds that comprise particulate matter less than 2.5 microns in diameter, and the proposed study will be the first to investigate associations between these compounds and pediatric emergency department visits in a birth cohort. Complex interactions between ambient air pollutants and airborne pollens on pediatric asthma exacerbations will be investigated using an innovative modeling approach based on two- dimensional loess smoothers in the framework of generalized additive models.
Ambient air pollutants are known to cause asthma exacerbations in children. To inform public health policy decisions it is important to know whether certain subgroups of asthmatic children have increased susceptibility to air pollutants, and the proposed study will be the first to investigate whether children who were born premature or low birth weight have an increased susceptibility to air pollution.
描述(由申请人提供):在宫内和早期生活经历会影响生理发育,并会影响一生中对环境因素的敏感性。然而,研究环境空气污染物浓度与儿童哮喘恶化之间关系的研究人员通常无法获得有关早期生活风险因素的数据。在乔治亚州,出生记录(1994-2007年)与佐治亚州人力资源部工作人员的儿科急诊科就诊(2002-2007年)有关。这种180万出生记录和550万儿科急诊科就诊之间的新联系将被用来调查早产或低出生体重的儿童是否比他们的同龄人对环境空气污染物浓度更敏感。如果观察到按胎龄或出生体重进行效果调整,那么这些发现将有助于为公共卫生政策决策提供信息,因为保护敏感亚群是环境保护局作为监管机构的使命的核心。此外,在大都会亚特兰大,一个研究空气质量监测站提供直径小于2.5微米的一整套颗粒物成分的每日浓度,这一资源通常也不向调查人员提供。这些测量可以用来区分由直径小于2.5微米的颗粒物组成的各种化合物,拟议中的研究将首次在出生队列中调查这些化合物与儿科急诊科就诊之间的关联。在广义加性模型的框架下,将使用基于二维黄土平滑器的创新建模方法来研究环境空气污染物与空气中花粉之间的复杂相互作用对儿童哮喘恶化的影响。
众所周知,环境空气污染物会导致儿童哮喘加重。要为公共卫生政策决策提供信息,重要的是要知道哮喘儿童的某些亚群是否增加了对空气污染物的易感性,拟议中的研究将首次调查早产或低出生体重的儿童是否对空气污染增加易感性。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pediatric Emergency Visits and Short-Term Changes in PM2.5 Concentrations in the U.S. State of Georgia.
- DOI:10.1289/ehp.1509856
- 发表时间:2016-05
- 期刊:
- 影响因子:10.4
- 作者:Strickland MJ;Hao H;Hu X;Chang HH;Darrow LA;Liu Y
- 通讯作者:Liu Y
Impact of exposure measurement error in air pollution epidemiology: effect of error type in time-series studies.
- DOI:10.1186/1476-069x-10-61
- 发表时间:2011-06-22
- 期刊:
- 影响因子:0
- 作者:Goldman GT;Mulholland JA;Russell AG;Strickland MJ;Klein M;Waller LA;Tolbert PE
- 通讯作者:Tolbert PE
Ciguatera fish poisoning and climate change: analysis of National Poison Center Data in the United States, 2001-2011.
Ciguatera鱼中毒和气候变化:2001 - 2011年美国国家毒物中心数据的分析。
- DOI:10.1289/ehp.1307196
- 发表时间:2014-06
- 期刊:
- 影响因子:10.4
- 作者:Gingold DB;Strickland MJ;Hess JJ
- 通讯作者:Hess JJ
Classification and regression trees for epidemiologic research: an air pollution example.
流行病学研究的分类和回归树:空气污染的例子。
- DOI:10.1186/1476-069x-13-17
- 发表时间:2014-03-13
- 期刊:
- 影响因子:0
- 作者:Gass K;Klein M;Chang HH;Flanders WD;Strickland MJ
- 通讯作者:Strickland MJ
Air Pollution and Preterm Birth in the U.S. State of Georgia (2002-2006): Associations with Concentrations of 11 Ambient Air Pollutants Estimated by Combining Community Multiscale Air Quality Model (CMAQ) Simulations with Stationary Monitor Measurements.
- DOI:10.1289/ehp.1409651
- 发表时间:2016-06
- 期刊:
- 影响因子:10.4
- 作者:Hao H;Chang HH;Holmes HA;Mulholland JA;Klein M;Darrow LA;Strickland MJ
- 通讯作者:Strickland MJ
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MATTHEW J. STRICKLAND其他文献
MATTHEW J. STRICKLAND的其他文献
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{{ truncateString('MATTHEW J. STRICKLAND', 18)}}的其他基金
Associations of smoke from wildfires and prescribed burns with cardiorespiratory health outcomes in Reno, NV
内华达州里诺市野火和规定烧伤产生的烟雾与心肺健康结果的关联
- 批准号:
9896826 - 财政年份:2019
- 资助金额:
$ 12.82万 - 项目类别:
Associations of smoke from wildfires and prescribed burns with cardiorespiratory health outcomes in Reno, NV
内华达州里诺市野火和规定烧伤产生的烟雾与心肺健康结果的关联
- 批准号:
10371222 - 财政年份:2019
- 资助金额:
$ 12.82万 - 项目类别:
Relationships between air pollutants and asthma exacerbations in a birth cohort
出生队列中空气污染物与哮喘恶化之间的关系
- 批准号:
8462269 - 财政年份:2010
- 资助金额:
$ 12.82万 - 项目类别:
Relationships between air pollutants and asthma exacerbations in a birth cohort
出生队列中空气污染物与哮喘恶化之间的关系
- 批准号:
8141238 - 财政年份:2010
- 资助金额:
$ 12.82万 - 项目类别:
Relationships between air pollutants and asthma exacerbations in a birth cohort
出生队列中空气污染物与哮喘恶化之间的关系
- 批准号:
8265640 - 财政年份:2010
- 资助金额:
$ 12.82万 - 项目类别:
Relationships between air pollutants and asthma exacerbations in a birth cohort
出生队列中空气污染物与哮喘恶化之间的关系
- 批准号:
7872398 - 财政年份:2010
- 资助金额:
$ 12.82万 - 项目类别:
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