Drug Dependence Clinical Research Program

药物依赖性临床研究计划

• 批准号: 8690805
• 负责人: NEAL L BENOWITZ
• 金额: $ 59.59万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8690805
• 关键词: Adenosine; Alcohols; Alkaloids; Analytical Chemistry; Biological Assay; Caffeine; Cancer Grant Supplements (P30); Clinic; Clinical Pharmacology; Clinical Psychology; Clinical Research; Cocaine; Consult; Data Analyses; Discipline; Drug Addiction; Drug Kinetics; Drug abuse; Drug usage; Ephedra; Funding; Grant; Health; Human; Individual; Institution; Institutional Review Boards; Internal Medicine; Label; Laboratories; Manuscripts; Measures; Methamphetamine; Neurology; Nicotine; Opiates; Organic Chemistry; Pediatrics; Persons; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacy facility; Phenethylamines; Preparation; Psychiatry; Psychopharmacology; Psychotropic Drugs; Request for Applications; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Services; Source; Synthesis Chemistry; Toxicogenetics; United States National Institutes of Health; addiction; analytical method; cost effective; drug abuse chemotherapy; drug addict; ecstasy; effective therapy; gamma hydroxybutyrate; heart pharmacology; innovation; interest; neurosteroids; programs; statistics; treatment strategy

DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects and assays available include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates. Analytical methods have been developed and validated in the core analytic laboratory to support studies with these drugs. Other new assays and labeled (deuterated) compounds will be made available to the associated research projects as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) to provide a state-of-the-art well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative support for manuscript preparation, IRB and related regulatory documents, grants management, and other research administrative services of value participating projects. (3) To provide statistical consulting services regarding study design and data analysis strategies, particularly optimal pharmacokinetic analysis to participating projects. The overall objective is to provide sophisticated analytic laboratory resources with stability of support together with adequate administrative support responsive to the needs of individual funded constituent scientific projects as those projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.

描述（由申请人提供）：此核心支持中心补助金（P30）申请要求继续支持分析和合成化学实验室和行政共享核心基础设施。参与的、目前得到资助的组成项目继续开展研究方案，包括对滥用药物的临床药理学、药物疗法和其他治疗药物滥用和成瘾的治疗策略进行人体实验室和治疗诊所研究。参与项目和现有分析的药物包括尼古丁及其代谢物、可卡因、甲基苯丙胺和其他苯乙胺、酒精、MDMA、阿米卡星生物碱、咖啡因、γ-羟基丁酸酯（GHB）、鼠尾草素、腺苷和神经类固醇以及阿片类药物。已在核心分析实验室开发并验证了分析方法，以支持这些药物的研究。其他新的检测方法和标记（氘代）化合物将根据需要提供给相关的研究项目。参与项目和研究人员所代表的学科包括精神病学、临床心理学、神经病学、普通内科学、心脏病学和临床药理学、精神药理学、毒理学、遗传学、儿科学、药学、有机、药物和分析化学以及统计学。我们的目标是：（1）为加州大学旧金山分校和其他机构的药物滥用研究人员的参与项目提供最先进的设备和人员配备，分析和合成化学实验室资源。(2)为有价值的参与项目的手稿准备、IRB和相关法规文件、赠款管理以及其他研究行政服务提供行政支持。(3)提供有关研究设计和数据分析策略的统计咨询服务，特别是对参与项目的最佳药代动力学分析。总体目标是提供具有稳定支持的先进分析实验室资源，并提供充分的行政支持，以满足各个受资助的组成科学项目随着这些项目的变化和发展而产生的需求。该设施是一个具有成本效益的共享实验室资源，增强和扩展了目前由NIH或其他联邦或非联邦来源资助的研究人员的研究可能性，以进一步了解人类精神活性药物的使用，滥用和成瘾，其健康后果及其治疗管理。