Investigating the interaction between BDNF and sex steroid hormones during adolescent development: relevance to schizophrenia

研究青少年发育过程中 BDNF 和性类固醇激素之间的相互作用：与精神分裂症的相关性

• 批准号: nhmrc : 1044887
• 负责人: Dr Rachel Hill
• 金额: $ 29.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigating-interaction-bdnf-relevance-schizophrenia/111697
• 关键词: Investigating; interaction; between; BDNF; sex

Schizophrenia first appears clinically during late adolescence. Sex hormones as well as growth factors such as Brain derived neurotrophic factor (BDNF) are involved in shaping the adolescent brain to its adult form. Alterations to these systems may contribute to structural changes seen in schizophrenia. This project will investigate the interaction of BDNF and sex hormones in the development of the adolescent mouse brain, and behavioural responses with relevance to schizophrenia.

精神分裂症首次出现在青春期后期的临床上。性激素和生长因子，如脑源性神经营养因子（BDNF），都参与了青少年大脑向成人形态的塑造。这些系统的改变可能有助于精神分裂症中看到的结构变化。这个项目将研究BDNF和性激素在青春期小鼠大脑发育中的相互作用，以及与精神分裂症相关的行为反应。