Understanding adolescent neurodevelopment: relevance to schizophrenia

了解青少年神经发育：与精神分裂症的相关性

• 批准号: nhmrc : GNT1062826
• 负责人: Dr Rachel Hill
• 金额: $ 40.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-adolescent-neurodevelopment-relevance-schizophrenia/1344820
• 关键词: Understanding; adolescent; neurodevelopment; relevance; schizophrenia

Schizophrenia first appears clinically during late adolescence. This project seeks to understand the molecular changes that occur during adolescent brain development that may underlie the behavioural abnormalities found in schizophrenia. We will focus on Brain derived neurotrophic factor (BDNF), a gene which when reduced is associated with schizophrenia. By examining the role of this gene during adolescent brain development, we will better understand how disruptions to this gene may lead to schizophrenia-like behaviours in adulthood.

精神分裂症首次出现在青春期后期的临床上。该项目旨在了解青少年大脑发育期间发生的分子变化，这些变化可能是精神分裂症中发现的行为异常的基础。我们将集中在脑源性神经营养因子（BDNF），一个基因，当减少与精神分裂症。通过研究这种基因在青少年大脑发育过程中的作用，我们将更好地了解这种基因的破坏如何导致成年后的精神分裂症样行为。