Studying the two hit hypothesis of psychiatric illness: role of brain-derived neurotrophic factor (BDNF)

研究精神疾病的两次打击假说：脑源性神经营养因子（BDNF）的作用

• 批准号: nhmrc : 567116
• 负责人: Dr Rachel Hill
• 金额: $ 20.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studying-hit-hypothesis-factor-bdnf/116051
• 关键词: Studying; two; hit; hypothesis; psychiatric

Psychiatric illnesses such as schizophrenia and depression are caused by at least two major disrupting events in development: one during early brain development and one during-after puberty. We will use animal models of schizophrenia, induced by administering stressors such as maternal separation, corticosterone or cannabinoid treatment at different stages of their lives. These animal models will be used to further investigate antipsychotic treatment therapies

精神分裂症和抑郁症等精神疾病至少是由发育过程中的两种主要干扰事件引起的：一种是大脑发育早期，另一种是青春期后。我们将使用精神分裂症的动物模型，这些模型是通过在生命的不同阶段给予压力源（例如母亲分离、皮质酮或大麻素治疗）而诱发的。这些动物模型将用于进一步研究抗精神病药物治疗