Modeling early intervention in schizophrenia: role of BDNF

精神分裂症早期干预建模：BDNF 的作用

• 批准号: nhmrc : 1044777
• 负责人: Dr Rachel Hill
• 金额: $ 31.16万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/modeling-early-intervention-role-bdnf/111688
• 关键词: Modeling; early; intervention; schizophrenia; role

Schizophrenia is a major burden on sufferers and society at large. Currently available treatments are only partially effective and often associated with significant side effects. This project will explore the neurobiological mechanisms of early preventative treatments in schizophrenia using a 'two hit' developmental mouse model. The results could have important clinical implcations for preventative treatment options.

精神分裂症对患者和整个社会都是一个重大负担。目前可用的治疗方法仅部分有效，而且往往伴有明显的副作用。该项目将利用发育小鼠模型探索精神分裂症早期预防性治疗的神经生物学机制。该结果可能对预防性治疗方案具有重要的临床意义。