Core Center for Integrated Research on Human Communication Disorders

人类沟通障碍综合研究核心中心

• 批准号: 8589583
• 负责人: CHARLES R LARSON
• 金额: $ 41.14万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8589583
• 关键词: Advanced Development; Autistic Disorder; Behavioral; Body part; Brain; Child; Cognitive; Collaborations; Collection; Communication; Communication Research; Communication impairment; Complex; Core Facility; Data; Data Analyses; Data Storage and Retrieval; Databases; Development; Diagnostic; Disabled Persons; Disease; Electrical Engineering; Electroencephalography; Enrollment; Etiology; Fostering; Functional Magnetic Resonance Imaging; Funding; Graph; Health; Hearing; Hearing problem; Human; Human Resources; Individual; Investigation; Laboratories; Language; Larynx; Linguistics; Motor; Neurology; Neurophysiology - biologic function; Otolaryngology; Outcome; Participant; Perception; Physical Medicine; Physical Rehabilitation; Population; Population Study; Prevention; Process; Production; Protocols documentation; Recording of previous events; Recruitment Activity; Registries; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Science; Scientist; Secure; Social Welfare; Societies; Speech; System; Techniques; Testing; Theoretical model; Universities; Vision; Work; analytical tool; computer science; data management; flexibility; handicapping condition; human subject; innovation; interdisciplinary approach; language processing; large-scale database; multisensory; neuromechanism; patient population; public health relevance; ranpirnase; relating to nervous system; relational database; remediation; research study; respiratory; screening; skills; tool; tool development

DESCRIPTION: The complexity of human communication disorders requires collaborative research between investigators utilizing a variety of skills and techniques. The proposal seeks funding to provide infrastructure support to researchers at Northwestern University who conduct research on the science and disorders of human communication. Through the establishment of three core facilities, this project will provide support to a group of investigators studying the processes involved in normal and disordered hearing, language processing, and speech production. Core 1 will hire personnel to recruit specific populations of hard-to-reach subjects such as children with autism, small children and older people and to administer routine and standardized screening tests. Core 2 will develop centralized and standardized tools for human subject management and data gathering, and will establish a research participant registry and relational database that will facilitate the secure storage and retrieval of data pertaining to subject groups and screening profiles. Finally, Core 3 will develop, deploy and customize techniques for analysis of fMRI and EEG that can be used by various labs to develop connectivity and graph theoretic models of neural mechanisms underlying normal and disordered communication. The net outcome from the work in the three cores will be an increase in collaborative research among investigators, the development of a database containing screening profiles and results of experimental studies of individuals with a variety of communication disorders, and the development of advanced mathematical tools for investigators using fMRI and EEG techniques for the analysis of neural mechanisms related to normal and disordered communication. The innovative outcome of this project will be the establishment of screening tests and experimental protocols that are most reliable for identifying markers of underlying etiologies of disorders of communication.

描述：人类沟通障碍的复杂性要求研究人员利用各种技能和技术进行合作研究。该提案寻求资金，为西北大学的研究人员提供基础设施支持，这些研究人员从事人类交流科学和障碍的研究。通过建立三个核心设施，该项目将为一组研究正常和紊乱的听力、语言处理和言语产生过程的调查人员提供支持。Core 1将招聘人员招募难以接触到的特定人群，如自闭症儿童、幼儿和老年人，并进行例行和标准化的筛查测试。核心2将开发用于人类主题管理和数据收集的集中和标准化工具，并将建立一个研究参与者登记册和关系数据库，以便利与主题组和筛选概况有关的数据的安全存储和检索。最后，Core 3将开发、部署和定制用于分析fMRI和EEG的技术，这些技术可供各种实验室使用，以开发正常和混乱通信背后的神经机制的连接性和图论模型。这三个核心工作的净成果将是增加调查人员之间的合作研究，开发一个数据库，其中包含对各种沟通障碍患者的筛选资料和实验研究结果，并为调查人员开发先进的数学工具，使用功能磁共振成像和脑电技术分析与正常和障碍沟通有关的神经机制。该项目的创新成果将是建立最可靠的筛查测试和实验方案，以确定沟通障碍潜在病因的标记。