Efficacy and neurobiological mechanisms of mobile-delivered cognitive retraining

项目总结

Project Summary This Mentored Research Scientist Development application (K01) will provide protected time for Dr. Matthew Pearson to develop a focused program of research in experimental psychopathology and its' application to the study of mechanisms of addictive behavior change. The aims of the 5-year career development plan are tightly integrated and will increase knowledge and experience in the areas of 1) cognitive models of addiction and their applications for cognitive retraining approaches, 2) addiction neuroscience and neuroimaging techniques (i.e., functional magnetic resonance imaging, fMRI), 3) mechanisms of behavior change (i.e., affective, cognitive, and neurobiological),4) advanced quantitative methods of analyzing longitudinal data (e.g., growth mixture modeling), and 5) grant writing. The career development plan includes structured meetings with mentors; seven graduate level courses in neuroscience, cognitive psychology, and statistics; and attending relevant conferences and workshops to develop substantive expertise and advanced training in quantitative/research methods and statistical software use. Supporting the career aims, the research plan includes a meta-analysis (year 1), a systematic review (year 2), and one primary empirical study that includes self-report, behavioral, and neuroimaging measures (years 1-5). The meta-analysis will examine moderators of the efficacy of cognitive retraining on alcohol use, and the systematic review will integrate previous findings to summarize putative neurobiological mechanisms of behavior change following cognitive retraining. These research syntheses will serve to consolidate knowledge gains and to nest the results of the proposed research study into the broader literature. Timing and sequencing of the research plan is intended to consolidate and extend knowledge gains associated with planned career development activities. The proposed study will use a longitudinal experimental design (N~95) to examine the linkages between cognitive and neurobiological mechanisms of behavior change following attentional bias modification (vs. attentional bias control) or working memory training (vs. working memory control) developed to be delivered via a mobile electronic device (e.g., smart phone) in heavy drinking adults. Ecological momentary assessment methods will be used to examine psychological mechanisms of behavior change over a 4-week period of time (e.g., attentional bias) and fMRI will be used to examine neural mechanisms of behavior change (e.g., pre-post changes in cue-elicited neural activation in the ventral striatum). Secondary data analyses will also support the career development of the candidate over the entire course of the award. Dr. Katie Witkiewitz will be primary mentor and has recognized expertise in many areas specific to the aims of this application. Drs. J. Scott Tonigan and Eric Claus will serve as secondary mentors supporting the candidate in selected areas including grant writing, meta-analysis, and fMRI techniques. Drs. Marsha Bates and Reinout Wiers will serve as consultants and will assist Dr. Pearson to consolidate knowledge gains in neural mechanisms of behavior change and cognitive retraining methods.