Efficacy and neurobiological mechanisms of mobile-delivered cognitive retraining

移动认知再训练的功效和神经生物学机制

• 批准号: 9288094
• 负责人: Matthew Ryan Pearson
• 金额: $ 16.65万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-15 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9288094
• 关键词: Addictive Behavior; Adult; Affective; Alcohol consumption; Alcohols; Anterior; Area; Award; Behavioral; Behavioral Mechanisms; Cellular Phone; Chiroptera; Cognition; Cognitive; Cognitive Science; Computer software; Control Groups; Cues; Data; Data Analyses; Development; Development Plans; Dorsal; Ecological momentary assessment; Educational workshop; Electronics; Ensure; Experimental Designs; Functional Magnetic Resonance Imaging; Goals; Grant; Growth; Heavy Drinking; Imaging Techniques; Impulsivity; In Situ; Incentives; Individual; Inferior frontal gyrus; Intervention; Knowledge; Lateral; Literature; Measures; Mediating; Mental Processes; Mentors; Meta-Analysis; Methods; Modeling; Modification; Motivation; Neurobiology; Neuronal Plasticity; Neurosciences; Outcome; Patient Self-Report; Prefrontal Cortex; Prevention; Procedures; Process; Psyche structure; Psychopathology; Randomized; Research; Research Methodology; Research Personnel; Rewards; Scanning; Scientist; Short-Term Memory; Stress; Structure; Techniques; Testing; Time; Training; Ventral Striatum; Ventral Tegmental Area; Volition; Writing; active control; addiction; alcohol abuse therapy; alcohol cue; alcohol intervention; alcohol misuse; alcohol use disorder; attentional bias; base; behavior change; behavior measurement; career; career development; cingulate cortex; cognitive control; cognitive retraining; computerized; cost effectiveness; design; efficacy testing; executive function; experience; improved; interest; longitudinal analysis; meetings; mobile application; neural circuit; neurobiological mechanism; neuroimaging; neuromechanism; programs; psychologic; public health relevance; reduced alcohol use; relating to nervous system; research study; response; statistics; symposium; systematic review; theories

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development application (K01) will provide protected time for Dr. Matthew Pearson to develop a focused program of research in experimental psychopathology and its' application to the study of mechanisms of addictive behavior change. The aims of the 5-year career development plan are tightly integrated and will increase knowledge and experience in the areas of 1) cognitive models of addiction and their applications for cognitive retraining approaches, 2) addiction neuroscience and neuroimaging techniques (i.e., functional magnetic resonance imaging, fMRI), 3) mechanisms of behavior change (i.e., affective, cognitive, and neurobiological),4) advanced quantitative methods of analyzing longitudinal data (e.g., growth mixture modeling), and 5) grant writing. The career development plan includes structured meetings with mentors; seven graduate level courses in neuroscience, cognitive psychology, and statistics; and attending relevant conferences and workshops to develop substantive expertise and advanced training in quantitative/research methods and statistical software use. Supporting the career aims, the research plan includes a meta-analysis (year 1), a systematic review (year 2), and one primary empirical study that includes self-report, behavioral, and neuroimaging measures (years 1-5). The meta-analysis will examine moderators of the efficacy of cognitive retraining on alcohol use, and the systematic review will integrate previous findings to summarize putative neurobiological mechanisms of behavior change following cognitive retraining. These research syntheses will serve to consolidate knowledge gains and to nest the results of the proposed research study into the broader literature. Timing and sequencing of the research plan is intended to consolidate and extend knowledge gains associated with planned career development activities. The proposed study will use a longitudinal experimental design (N~95) to examine the linkages between cognitive and neurobiological mechanisms of behavior change following attentional bias modification (vs. attentional bias control) or working memory training (vs. working memory control) developed to be delivered via a mobile electronic device (e.g., smart phone) in heavy drinking adults. Ecological momentary assessment methods will be used to examine psychological mechanisms of behavior change over a 4-week period of time (e.g., attentional bias) and fMRI will be used to examine neural mechanisms of behavior change (e.g., pre-post changes in cue-elicited neural activation in the ventral striatum). Secondary data analyses will also support the career development of the candidate over the entire course of the award. Dr. Katie Witkiewitz will be primary mentor and has recognized expertise in many areas specific to the aims of this application. Drs. J. Scott Tonigan and Eric Claus will serve as secondary mentors supporting the candidate in selected areas including grant writing, meta-analysis, and fMRI techniques. Drs. Marsha Bates and Reinout Wiers will serve as consultants and will assist Dr. Pearson to consolidate knowledge gains in neural mechanisms of behavior change and cognitive retraining methods.

描述（由申请人提供）：此指导研究科学家发展申请（K01）将为Matthew Pearson博士提供保护时间，以开发实验精神病理学的重点研究项目及其在成瘾行为改变机制研究中的应用。5年职业发展计划的目标是紧密结合的，并将增加以下领域的知识和经验：1)成瘾的认知模型及其在认知再训练方法中的应用；2)成瘾神经科学和神经成像技术（即功能磁共振成像，fMRI）； 3)行为改变机制（即情感，认知和神经生物学）；4)纵向数据分析的先进定量方法(例如：生长混合模型)和5)拨款写作。职业发展计划包括与导师的结构化会议；七门研究生课程，包括神经科学、认知心理学和统计学；并参加有关的会议和讲习班，以发展数量/研究方法和统计软件使用方面的实质性专门知识和高级培训。为了支持学生的职业目标，研究计划包括一项荟萃分析（一年级）、一项系统综述（二年级）和一项主要实证研究（1-5年级），其中包括自我报告、行为和神经影像学测量。荟萃分析将检验认知再训练对酒精使用效果的调节因子，系统综述将整合先前的研究结果，总结认知再训练后行为改变的假定神经生物学机制。这些研究综合将有助于巩固知识收益，并将拟议研究的结果嵌入更广泛的文献中。研究计划的时间和顺序是为了巩固和扩大与计划的职业发展活动有关的知识所得。该研究将采用纵向实验设计（N~95）来检验重度饮酒成人在注意偏差修正（相对于注意偏差控制）或工作记忆训练（相对于工作记忆控制）后行为改变的认知和神经生物学机制之间的联系，这些训练是通过移动电子设备（如智能手机）进行的。生态瞬间评估方法将被用于在4周的时间内检查行为改变的心理机制（例如，注意偏差），功能磁共振成像将被用于检查行为改变的神经机制（例如，腹侧纹状体中线索引发的神经激活的前后变化）。二级数据分析也将支持候选人在整个获奖过程中的职业发展。Katie Witkiewitz博士将是主要的导师，她在许多领域都有公认的专业知识，专门针对这个应用程序的目标。Drs。J. Scott Tonigan和Eric Claus将作为辅助导师，在选定的领域为候选人提供支持，包括拨款写作、元分析和功能磁共振成像技术。Drs。Marsha Bates和Reinout Wiers将担任顾问，并协助Pearson博士巩固在行为改变和认知再训练方法的神经机制方面的知识收获。