Regenerative Musculoskeletal Medicine Training Program

再生肌肉骨骼医学培训计划

• 批准号: 8727970
• 负责人: John S Adams
• 金额: $ 21.97万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-11 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727970
• 关键词: Medicine; Musculoskeletal; Training Programs; regenerative

DESCRIPTION (provided by applicant): Project Summary The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.

描述（由申请人提供）：项目摘要创建该培训计划的动机是再生医学领域的出现和成熟，尤其是与肌肉骨骼疾病有关。研究的重点将放在重建受伤或缺失的肌肉骨骼组织，该细胞和嵌入具有与天然组织相似的纳米结构的生物苏斯福克或基质中的细胞和小分子。我们将专注于培训前和博士后学员，后者涉及博士学位和M.D.S博士学位，意图是再生效率医学一般领域的跨学科学术医学职业。第一个主要目标是为学员提供1）干细胞和发育生物学中的组合技能集，2）分子遗传学，3）组织工程和材料科学，4）在高通量，大规模计算科学和5）临床经济学药物中的最先进技术中，可以层次地培训这些领域的培训和毕业生的培训。第二个主要目标是通过动手以项目的构建方式进行动手实践的教学来教育受训者再生医学的综合方法。我们将创建并维护由三方组成的三方团队组成的肌肉骨骼再生医学研究所（IIMSRM），由1）A培训学院，2）临床教师导师和3）受训者。这种团队的方法将确保受训者将获得全面的基准对床层经验，以实现“现实世界”中的生物工程治疗所需的内容。这种翻译研究结构将得到强大的教学课程和研讨会系列的支持，旨在介绍和完善博物前和博士后学员所需的技能，以了解，设计，设计，组成，承诺并赢得对再生医学研究项目的校外财务支持。 IIMSRM研究和教学培训计划旨在为单个学员提供两年的支持，以准备过渡到更专业的培训和替代支持来源。