Regenerative Musculoskeletal Medicine Training Program

描述（由申请人提供）：项目摘要创建该培训计划的动机是再生医学领域的出现和成熟，特别是与肌肉骨骼疾病有关。研究重点将是用嵌入生物支架或基质中的细胞和小分子重建受损或缺失的肌肉骨骼组织，该生物支架或基质具有与天然组织相似的纳米结构。我们将把培训工作的重点放在博士前和博士后水平的学员，后者涉及博士和医学博士，打算在再生恢复医学的一般领域的跨学科学术医学的职业生涯。第一个主要目标将是为学员提供1）干细胞和发育生物学，2）分子遗传学，3）组织工程和材料科学，4）高通量，大规模计算科学和5）临床转化医学的最新技术的组合技能集可以在这些领域之一的本科和研究生培训之上分层。第二个主要目标将是教育学员在一个综合的方法，以再生医学与实践项目为导向的教学如何i]建立，ii]操作和iii]修改一个多学科的同事团队。我们将创建和维护肌肉骨骼再生医学（IIMSRM）的跨学科研究所组成的三方团队1）培训教师，2）临床教师导师和3）实习生。这种团队方法将确保受训者将获得全面的从实验室到临床的经验，了解在“真实的世界”中实现生物工程治疗所需的内容。这种转化研究结构将得到教学课程和研讨会系列的强大集合的支持，旨在介绍和完善博士前和博士后学员所需的技能，以理解，设计，撰写，承担和获得再生医学研究项目的校外财政支持。该研究所的研究和教学培训方案旨在为个别受训者提供两年的支助，为他们过渡到更专业的培训和其他支助来源做准备。

DESCRIPTION (provided by applicant): Project Summary The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.