Regenerative Musculoskeletal Medicine Training Program

描述(由申请者提供)：项目摘要创建该培训计划的动机是再生医学领域的出现和成熟，特别是与肌肉骨骼疾病有关的领域。研究的重点将是重建受损或丢失的肌肉骨骼组织，将细胞和小分子嵌入具有与自然组织类似的纳米结构的生物支架或基质中。我们将重点培训博士后和博士后水平的学员，后者包括博士和医学博士，他们打算在再生-恢复医学的一般领域从事跨学科学术医学的职业生涯。第一个主要目标是为学员提供1)干细胞和发育生物学、2)分子遗传学、3)组织工程和材料科学、4)高通量、大规模计算科学和5)临床转化医学的组合技能，这些技能可以在这些领域中先前的本科和研究生培训的基础上进行。第二个主要目标将是通过以实践项目为导向的教学，用再生医学的综合方法教育受训人员如何建立、运作和修改一个多学科的同事团队。我们将创建和维持一个肌肉骨骼再生医学跨学科研究所(IIMSRM)，由一个由1)培训教师、2)临床教师导师和3)实习生组成的三方团队组成。这种团队方法将确保受训者将获得全面的从床到床的体验，这是实施“真实世界”生物工程疗法所必需的。这一转化性研究结构将得到强大的教学课程和系列研讨会的支持，旨在介绍和完善博士后和博士后受训人员理解、设计、撰写、从事再生医学研究项目并获得校外资金支持所需的技能。IIMSRM研究和教学培训计划旨在为个别学员提供两年的支持，为他们过渡到更专业的培训和替代支持来源做准备。

DESCRIPTION (provided by applicant): Project Summary The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.