Regenerative Musculoskeletal Medicine Training Program

本培训项目的创建动机是再生医学领域的出现和成熟，特别是与肌肉骨骼疾病相关的领域。研究的重点是将细胞和小分子嵌入生物支架或基质中，使其具有与天然组织相似的纳米结构，从而重建受伤或缺失的肌肉骨骼组织。重点培养在再生-恢复医学领域从事跨学科学术医学工作的博士后和博士后，博士后包括博士和医学博士。第一个主要目标将是为学员提供以下方面的组合技能：1)干细胞和发育生物学，2)分子遗传学，3)组织工程和材料科学，4)高通量、大规模计算科学的最新技术，5)临床转化医学，这些技能可以在他们之前的本科和研究生培训的基础上进行分层。第二个主要目标将是通过以项目为导向的实践教学，向学员传授再生医学的综合方法，教他们如何[i]建立、[ii]在多学科团队中运作和[iii]修改团队成员。我们将建立和维持一个跨学科的肌肉骨骼再生医学研究所（IIMSRM），该研究所由三方组成：1)培训教员，2)临床教员导师和3)实习生。这种团队合作的方法将确保受训者获得全面的从临床到临床的经验，这是在“现实世界”中实现生物工程治疗所必需的。这种转化研究结构将由一系列有力的教学课程和系列研讨会提供支持，旨在介绍和完善博士前和博士后受训者理解、设计、撰写、承担和获得再生医学研究项目外部资金支持所需的技能。IIMSRM的研究和教学培训方案旨在为个别受训人员提供两年的支持，为他们过渡到更专业的培训和其他支持来源做准备。

DESCRIPTION (provided by applicant): Project Summary The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.