Regenerative Musculoskeletal Medicine Training Program

描述（由申请人提供）： 项目摘要 创建该培训计划的动机是再生医学领域的出现和成熟，特别是因为它与肌肉骨骼疾病相关。研究重点将是利用嵌入生物支架或基质中的细胞和小分子来重建受损或缺失的肌肉骨骼组织，该生物支架或基质具有与天然组织相似的纳米结构。我们将重点培训博士前和博士后水平的学员，后者包括博士和医学博士，致力于再生恢复医学领域跨学科学术医学的职业生涯。第一个主要目标是为学员提供以下方面的组合技能：1) 干细胞和发育生物学，2) 分子遗传学，3) 组织工程和材料科学，4) 高通量、大规模计算科学的最先进技术，以及 5) 临床转化医学，这些技能可以叠加在他们之前在这些领域之一的本科和研究生培训之上。第二个主要目标是通过以项目为导向的实践教学，对学员进行再生医学综合方法的教育，让他们了解如何 i] 建立、ii] 操作和 iii] 修改多学科同事团队。我们将创建和维护一个跨学科的肌肉骨骼再生医学研究所 (IIMSRM)，由三方团队组成：1) 培训教师、2) 临床教师导师和 3) 实习生。这种团队方法将确保学员获得全面的从实验室到临床的经验，了解在“现实世界”中实现生物工程治疗所需的知识。这种转化研究结构将得到一系列强大的教学课程和研讨会系列的支持，旨在介绍和完善博士前和博士后学员所需的技能，以理解、设计、撰写、承担和获得再生医学研究项目的校外财政支持。 IIMSRM 研究和教学培训计划旨在为个别学员提供两年的支持，为他们过渡到更专业的培训和替代支持来源做好准备。

DESCRIPTION (provided by applicant): Project Summary The motivation for creation of this training program is the emergence and maturation of the field of regenerative medicine, especially as it relates to musculoskeletal disease. Investigational focus will be on the reconstitution of injured or missing musculoskeletal tissues with cells and small molecules embedded in a bioscaffold or matrix that possesses a nanostructure similar to that of the native tissue. We will focus training efforts on both the pre- and post-doctoral level trainees, the latter involving both Ph.D.s and M.D.s, intent on a career in interdisciplinary academic medicine in the general area of regenerative-restorative medicine. The first primary goal will be to provide trainees with combinatorial skill sets in 1) stem cell and developmental biology, 2) molecular genetics, 3) tissue engineering and materials science, 4) state-of the-art technologies in high-throughput, large scale computational science and 5) clinical-translational medicine that can be layered on top of their preceding undergraduate and graduate training in one of these areas. The second primary goal will be to educate trainees in an integrated approach to regenerative medicine with hands-on project-oriented teaching in how to i] build, ii] operate in and iii] modify a multidisciplinary team of colleagues. We will create and maintain an Interdisciplinary Institute of Musculoskeletal Regenerative Medicine (IIMSRM) composed of a tripartite team of 1) a training faculty, 2) a clinical faculty mentor and 3) a trainee. This team approach will ensure that the trainees will receive a comprehensive bench-to-bedside experience in what is required to actualize a bioengineered therapeutic in "real world" terms. This translational research structure will be supported by a robust collection of didactic curricula and seminar series, designed to introduce and refine the skills needed by both pre- and post-doctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. The IIMSRM research and didactic training program is designed to provide individual trainees two years of support in preparation for their transition into more specialized training and alternative sources of support.