Regenerative Musculoskeletal Medicine Training Program

项目摘要 在过去的十年里，我们建立了一个专注于再生医学的培训计划， 肌肉骨骼疾病受训人员开展的项目涉及到基本机制， 肌肉骨骼细胞的承诺和分化的发展和疾病，重建受伤或 缺少具有细胞、支架和生物活性分子的肌肉骨骼组织，使用生物信息学来解决 肌肉骨骼疾病和治疗，以及对抗植入物感染的策略。一个最独特的 我们计划的属性是为骨科手术住院医师提供培训经验， 使他们能够完成与临床/翻译扩展相关的实验室研究项目 在住院医师计划的范围内完成这个项目这导致了另一种独特的 我们的计划的一个方面，一个指导团队的MD和博士生组成的一个额外的资助 基础或转化科学家，资助临床科学家和执业学术外科医生导师。 这些新的组成部分已经非常成功，导致教师的兴趣大大增加 和学员之间的互动和增加MD和博士学员。我们建议从四个实习生 由于去年申请该计划的合格申请人数量增加了两倍， 三个请求。加州大学洛杉矶分校矫形外科系主任已承诺提供资金， 这将有助于减少这一扩展的业务费用，并丰富总体培训经验。以试点研究为基础 我们建议改善对学员和导师的评估， 围绕标准化的基于调查的工具使用可量化的指标， 培训团队成员。根据咨询委员会和学员的意见，我们使培训教师多样化， 包括保健服务/成果和工程方面专门知识。最后，着眼于继任计划， 我们增加了第三个MPI尼古拉斯伯恩塔尔，医学博士，一个年轻的教员谁已经成功地建立了一个 在保持临床实践的同时，还可以进行校外资助的实验室研究项目。 我们的翻译研究结构是由一个强大的教学课程和系列研讨会的集合支持 旨在介绍和完善博士后学员所需的技能，以理解，设计，作曲， 承担并获得再生医学研究项目的校外资金支持。增加 重点将放在博士生接触高度相关的临床挑战和接触 外科医生科学家在再生骨科医学领域的基础研究。T32研究和 教学培训计划旨在为个别学员提供2-3年的资金， 他们过渡到更专业的培训，并作为一个指导支持， 超过了他们对T32的任命期限。

Project Summary Over the past ten years, we have established a training program focused on regenerative medicine as it relates to musculoskeletal disease. Projects undertaken by trainees have addressed mechanisms underlying musculoskeletal cell commitment and differentiation in development and disease, reconstitution of injured or missing musculoskeletal tissues with cells, scaffolds and bioactive molecules, use of bioinformatics to address musculoskeletal diseases and treatment, and strategies to combat implant infections. One of the most unique attributes of our program is the development of a training experience for orthopaedic surgery residents that enables them to complete a laboratory-based research project connected to a clinical/ translational extension of the project within the confines of the residency program. This led to the development of another unique aspect of our program, a mentoring team for both MD and PhD trainees comprised of an extramurally-funded basic or translational scientist, a funded clinician scientist and a practicing academic surgeon mentor. These new components have been highly successful, leading to substantially increased interest among faculty and trainees and increased interaction between MD and PhD trainees. We propose to expand from four trainee positions to five owing to a tripling in the number of qualified applicants applying to the program in the last three solicitations. The Chair of the UCLA Department of Orthopaedic Surgery has pledged funds to cover operational costs of this expansion and to enrich the overall training experience. Grounded in a pilot study performed in the current funding period, we propose to improve our evaluation of trainees and mentors by using quantifiable metrics around standardized survey-based instruments that track the longitudinal progress of training team members. Based on input from advisory boards and trainees, we diversified our training faculty to include expertise in health services/outcomes and engineering. Finally, with an eye on succession planning, we added a third MPI Nicholas Bernthal, MD, a young faculty member who has succeeded in establishing an extramurally-funded bench research program while maintaining a clinical practice. Our translational research structure is supported by a robust collection of didactic curricula and seminar series designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. Increased focus will be placed on exposure of PhD trainees to highly relevant clinical challenges and exposure of surgeon scientists to basic research in the field of regenerative orthopaedic medicine. The T32 research and didactic training program is designed to provide individual trainees with 2-3 years of funding in preparation for their transition into more specialized training and to serve as a source of mentoring support that extends beyond their term of appointment to the T32.