Regenerative Musculoskeletal Medicine Training Program

项目摘要 在过去的十年里，我们建立了一个以再生医学为重点的培训计划 肌肉骨骼疾病。受训人员开展的项目解决了潜在的机制 肌肉骨骼细胞在发育和疾病、损伤或修复中的定位和分化 丢失肌肉骨骼组织的细胞、支架和生物活性分子，使用生物信息学来解决 肌肉骨骼疾病和治疗，以及抗击种植体感染的战略。世界上最独特的 我们计划的特点是为骨科住院医生开发培训体验， 使他们能够完成与临床/翻译扩展相关的基于实验室的研究项目 在驻留计划范围内的项目。这导致了另一种独特的 在我们的计划方面，为医学博士和博士实习生设立的指导团队由一名校外资助的 基础或转化型科学家、临床医生资助科学家和执业学术外科医生导师。 这些新的组成部分非常成功，大大增加了教职员工的兴趣 和受训人员，以及增加医学博士和博士生之间的互动。我们建议从四名实习生扩大到 职位增至5个，原因是去年申请该项目的合格申请者数量增加了两倍 三次征集。加州大学洛杉矶分校整形外科主席承诺为 这一扩大的业务成本和丰富的整体培训经验。以先导研究为基础 在目前的资助期内，我们建议通过以下方式改进对学员和导师的评估 围绕基于调查的标准化工具使用可量化的指标，这些工具跟踪 培训团队成员。根据咨询委员会和实习生的意见，我们将培训人员多样化，以 包括保健服务/成果和工程方面的专门知识。最后，着眼于继任规划， 我们增加了第三个MPI，医学博士尼古拉斯·伯恩塔尔，他是一名年轻的教职员工，他成功地建立了 在维持临床实践的同时，由医疗外资金资助的BASE研究计划。 我们的翻译研究结构得到了强大的教学课程和系列研讨会的支持 旨在介绍和完善博士后实习生理解、设计、写作、 承担并获得再生医学研究项目的校外资金支持。增加了 重点将放在博士生面临高度相关的临床挑战和接触 外科科学家致力于再生骨科领域的基础研究。T32研究和 教学培训计划旨在为个别学员提供2-3年的资金，为 他们将过渡到更专业的培训，并作为指导支持的来源 超过他们对T32的任期。

Project Summary Over the past ten years, we have established a training program focused on regenerative medicine as it relates to musculoskeletal disease. Projects undertaken by trainees have addressed mechanisms underlying musculoskeletal cell commitment and differentiation in development and disease, reconstitution of injured or missing musculoskeletal tissues with cells, scaffolds and bioactive molecules, use of bioinformatics to address musculoskeletal diseases and treatment, and strategies to combat implant infections. One of the most unique attributes of our program is the development of a training experience for orthopaedic surgery residents that enables them to complete a laboratory-based research project connected to a clinical/ translational extension of the project within the confines of the residency program. This led to the development of another unique aspect of our program, a mentoring team for both MD and PhD trainees comprised of an extramurally-funded basic or translational scientist, a funded clinician scientist and a practicing academic surgeon mentor. These new components have been highly successful, leading to substantially increased interest among faculty and trainees and increased interaction between MD and PhD trainees. We propose to expand from four trainee positions to five owing to a tripling in the number of qualified applicants applying to the program in the last three solicitations. The Chair of the UCLA Department of Orthopaedic Surgery has pledged funds to cover operational costs of this expansion and to enrich the overall training experience. Grounded in a pilot study performed in the current funding period, we propose to improve our evaluation of trainees and mentors by using quantifiable metrics around standardized survey-based instruments that track the longitudinal progress of training team members. Based on input from advisory boards and trainees, we diversified our training faculty to include expertise in health services/outcomes and engineering. Finally, with an eye on succession planning, we added a third MPI Nicholas Bernthal, MD, a young faculty member who has succeeded in establishing an extramurally-funded bench research program while maintaining a clinical practice. Our translational research structure is supported by a robust collection of didactic curricula and seminar series designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. Increased focus will be placed on exposure of PhD trainees to highly relevant clinical challenges and exposure of surgeon scientists to basic research in the field of regenerative orthopaedic medicine. The T32 research and didactic training program is designed to provide individual trainees with 2-3 years of funding in preparation for their transition into more specialized training and to serve as a source of mentoring support that extends beyond their term of appointment to the T32.