Regenerative Musculoskeletal Medicine Training Program
Regenerative Musculoskeletal Medicine Training Program
批准号:
10451578
负责人:
John S Adams
金额:
$35.15万
依托单位国家:
美国
项目类别:
财政年份:
2011
资助国家:
美国
项目状态:
未结题
起止时间:
2011-08-11 至 2026-07-31
中文摘要
项目摘要
在过去的十年里,我们建立了一个专注于再生医学的培训计划,
肌肉骨骼疾病受训人员开展的项目涉及到基本机制,
肌肉骨骼细胞的承诺和分化的发展和疾病,重建受伤或
缺少具有细胞、支架和生物活性分子的肌肉骨骼组织,使用生物信息学来解决
肌肉骨骼疾病和治疗,以及对抗植入物感染的策略。一个最独特的
我们计划的属性是为骨科手术住院医师提供培训经验,
使他们能够完成与临床/翻译扩展相关的实验室研究项目
在住院医师计划的范围内完成这个项目这导致了另一种独特的
我们的计划的一个方面,一个指导团队的MD和博士生组成的一个额外的资助
基础或转化科学家,资助临床科学家和执业学术外科医生导师。
这些新的组成部分已经非常成功,导致教师的兴趣大大增加
和学员之间的互动和增加MD和博士学员。我们建议从四个实习生
由于去年申请该计划的合格申请人数量增加了两倍,
三个请求。加州大学洛杉矶分校矫形外科系主任已承诺提供资金,
这将有助于减少这一扩展的业务费用,并丰富总体培训经验。以试点研究为基础
我们建议改善对学员和导师的评估,
围绕标准化的基于调查的工具使用可量化的指标,
培训团队成员。根据咨询委员会和学员的意见,我们使培训教师多样化,
包括保健服务/成果和工程方面专门知识。最后,着眼于继任计划,
我们增加了第三个MPI尼古拉斯伯恩塔尔,医学博士,一个年轻的教员谁已经成功地建立了一个
在保持临床实践的同时,还可以进行校外资助的实验室研究项目。
我们的翻译研究结构是由一个强大的教学课程和系列研讨会的集合支持
旨在介绍和完善博士后学员所需的技能,以理解,设计,作曲,
承担并获得再生医学研究项目的校外资金支持。增加
重点将放在博士生接触高度相关的临床挑战和接触
外科医生科学家在再生骨科医学领域的基础研究。T32研究和
教学培训计划旨在为个别学员提供2-3年的资金,
他们过渡到更专业的培训,并作为一个指导支持,
超过了他们对T32的任命期限。
英文摘要
Project Summary
Over the past ten years, we have established a training program focused on regenerative medicine as it relates
to musculoskeletal disease. Projects undertaken by trainees have addressed mechanisms underlying
musculoskeletal cell commitment and differentiation in development and disease, reconstitution of injured or
missing musculoskeletal tissues with cells, scaffolds and bioactive molecules, use of bioinformatics to address
musculoskeletal diseases and treatment, and strategies to combat implant infections. One of the most unique
attributes of our program is the development of a training experience for orthopaedic surgery residents that
enables them to complete a laboratory-based research project connected to a clinical/ translational extension
of the project within the confines of the residency program. This led to the development of another unique
aspect of our program, a mentoring team for both MD and PhD trainees comprised of an extramurally-funded
basic or translational scientist, a funded clinician scientist and a practicing academic surgeon mentor.
These new components have been highly successful, leading to substantially increased interest among faculty
and trainees and increased interaction between MD and PhD trainees. We propose to expand from four trainee
positions to five owing to a tripling in the number of qualified applicants applying to the program in the last
three solicitations. The Chair of the UCLA Department of Orthopaedic Surgery has pledged funds to cover
operational costs of this expansion and to enrich the overall training experience. Grounded in a pilot study
performed in the current funding period, we propose to improve our evaluation of trainees and mentors by
using quantifiable metrics around standardized survey-based instruments that track the longitudinal progress of
training team members. Based on input from advisory boards and trainees, we diversified our training faculty to
include expertise in health services/outcomes and engineering. Finally, with an eye on succession planning,
we added a third MPI Nicholas Bernthal, MD, a young faculty member who has succeeded in establishing an
extramurally-funded bench research program while maintaining a clinical practice.
Our translational research structure is supported by a robust collection of didactic curricula and seminar series
designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose,
undertake and earn extramural financial support for a research project in regenerative medicine. Increased
focus will be placed on exposure of PhD trainees to highly relevant clinical challenges and exposure of
surgeon scientists to basic research in the field of regenerative orthopaedic medicine. The T32 research and
didactic training program is designed to provide individual trainees with 2-3 years of funding in preparation for
their transition into more specialized training and to serve as a source of mentoring support that extends
beyond their term of appointment to the T32.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Impact of ethnicity in the gut microbiome in response to oral vitamin D replacement
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批准号:9464319
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项目类别:
-
资助金额:$30.19万
-
财政年份:2017
-
负责人:John S Adams
-
依托单位:
Vitamin D Metabolism in Leprosy
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批准号:8531870
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项目类别:
-
资助金额:$31.6万
-
财政年份:2013
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负责人:John S Adams
-
依托单位:
DBP and the bioavailability and function of vitamin D
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批准号:8579492
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项目类别:
-
资助金额:$37.85万
-
财政年份:2013
-
负责人:John S Adams
-
依托单位:
DBP and the bioavailability and function of vitamin D
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批准号:9087001
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项目类别:
-
资助金额:$31.5万
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财政年份:2013
-
负责人:John S Adams
-
依托单位:
DBP and the bioavailability and function of vitamin D
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批准号:8728745
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项目类别:
-
资助金额:$40.13万
-
财政年份:2013
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负责人:John S Adams
-
依托单位:
Vitamin D Metabolism in Leprosy
-
批准号:8343695
-
项目类别:
-
资助金额:$33.26万
-
财政年份:2012
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:8521890
-
项目类别:
-
资助金额:$21.17万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:8727970
-
项目类别:
-
资助金额:$21.97万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:8078780
-
项目类别:
-
资助金额:$25.65万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:10197690
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项目类别:
-
资助金额:$27.92万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:8318695
-
项目类别:
-
资助金额:$25.68万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
-
批准号:10682414
-
项目类别:
-
资助金额:$42.7万
-
财政年份:2011
-
负责人:John S Adams
-
依托单位:
Regenerative Musculoskeletal Medicine Training Program
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批准号:9982779
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项目类别:
-
资助金额:$31.77万
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财政年份:2010
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负责人:John S Adams
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依托单位:
Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
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批准号:7904106
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项目类别:
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资助金额:$17.15万
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财政年份:2009
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负责人:John S Adams
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依托单位:
Orthopaedic Wear Debris, Vitamin D, and Innate Immunity
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批准号:7753825
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项目类别:
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资助金额:$20.79万
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财政年份:2009
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负责人:John S Adams
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依托单位:
EFFECTS OF VITAMIN D INSUFFICIENCY IN MAN
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批准号:8167126
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项目类别:
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资助金额:$0.2万
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财政年份:2009
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负责人:John S Adams
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依托单位:
VITAMIN D INSUFFICIENCY AS AN INTERVAL CAUSE OF DIMINISHED BONE MINERAL DENSITY
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批准号:7606111
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项目类别:
-
资助金额:$1.37万
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财政年份:2007
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负责人:John S Adams
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依托单位:
Vitamin D and Barrier Function
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批准号:6930315
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项目类别:
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资助金额:$28.39万
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财政年份:2004
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负责人:John S Adams
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依托单位:
Vitamin D and Barrier Function
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批准号:6824772
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项目类别:
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资助金额:$27.45万
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财政年份:2004
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负责人:John S Adams
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依托单位:
Genetic Determinants of Osteoporosis Susceptibility
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批准号:7042062
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项目类别:
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资助金额:$3.79万
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财政年份:2003
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负责人:John S Adams
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依托单位:
海外基金