Regenerative Musculoskeletal Medicine Training Program

再生肌肉骨骼医学培训计划

• 批准号: 10197690
• 负责人: John S Adams
• 金额: $ 27.92万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-11 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10197690
• 关键词: Medicine; Musculoskeletal; Training Programs; regenerative

Project Summary Over the past ten years, we have established a training program focused on regenerative medicine as it relates to musculoskeletal disease. Projects undertaken by trainees have addressed mechanisms underlying musculoskeletal cell commitment and differentiation in development and disease, reconstitution of injured or missing musculoskeletal tissues with cells, scaffolds and bioactive molecules, use of bioinformatics to address musculoskeletal diseases and treatment, and strategies to combat implant infections. One of the most unique attributes of our program is the development of a training experience for orthopaedic surgery residents that enables them to complete a laboratory-based research project connected to a clinical/ translational extension of the project within the confines of the residency program. This led to the development of another unique aspect of our program, a mentoring team for both MD and PhD trainees comprised of an extramurally-funded basic or translational scientist, a funded clinician scientist and a practicing academic surgeon mentor. These new components have been highly successful, leading to substantially increased interest among faculty and trainees and increased interaction between MD and PhD trainees. We propose to expand from four trainee positions to five owing to a tripling in the number of qualified applicants applying to the program in the last three solicitations. The Chair of the UCLA Department of Orthopaedic Surgery has pledged funds to cover operational costs of this expansion and to enrich the overall training experience. Grounded in a pilot study performed in the current funding period, we propose to improve our evaluation of trainees and mentors by using quantifiable metrics around standardized survey-based instruments that track the longitudinal progress of training team members. Based on input from advisory boards and trainees, we diversified our training faculty to include expertise in health services/outcomes and engineering. Finally, with an eye on succession planning, we added a third MPI Nicholas Bernthal, MD, a young faculty member who has succeeded in establishing an extramurally-funded bench research program while maintaining a clinical practice. Our translational research structure is supported by a robust collection of didactic curricula and seminar series designed to introduce and refine the skills needed by postdoctoral trainees to understand, design, compose, undertake and earn extramural financial support for a research project in regenerative medicine. Increased focus will be placed on exposure of PhD trainees to highly relevant clinical challenges and exposure of surgeon scientists to basic research in the field of regenerative orthopaedic medicine. The T32 research and didactic training program is designed to provide individual trainees with 2-3 years of funding in preparation for their transition into more specialized training and to serve as a source of mentoring support that extends beyond their term of appointment to the T32.

项目概要 在过去的十年里，我们建立了一个专注于再生医学的培训计划，因为它涉及 到肌肉骨骼疾病。受训者开展的项目已经解决了潜在的机制 肌肉骨骼细胞在发育和疾病中的承诺和分化，受伤或受损的重建 缺少细胞、支架和生物活性分子的肌肉骨骼组织，利用生物信息学来解决 肌肉骨骼疾病和治疗，以及对抗植入物感染的策略。最独特的之一 我们计划的特点是为骨科住院医师提供培训经验， 使他们能够完成与临床/转化延伸相关的基于实验室的研究项目 该项目在驻地计划的范围内。这导致了另一种独特的开发 我们项目的一个方面是，一个针对医学博士和博士生的指导团队由校外资助的 基础或转化科学家、受资助的临床科学家和执业学术外科医生导师。 这些新组件非常成功，极大地提高了教师的兴趣 和受训者，并增加医学博士和博士受训者之间的互动。我们建议将实习生人数从四名扩大到 由于去年申请该计划的合格申请者数量增加了两倍，职位增至五个 三项恳求。加州大学洛杉矶分校整形外科系主任已承诺提供资金以覆盖 此举扩大了运营成本并丰富了整体培训体验。以试点研究为基础 在当前资助期间，我们建议通过以下方式改进对学员和导师的评估： 使用围绕基于标准化调查的工具的量化指标来跟踪纵向进展 培训团队成员。根据顾问委员会和学员的意见，我们使培训师资队伍多样化， 包括卫生服务/成果和工程方面的专业知识。最后，着眼于继任计划， 我们增加了第三位 MPI Nicholas Bernthal 医学博士，他是一位年轻的教员，成功地建立了 外部资助的实验室研究项目，同时保持临床实践。 我们的转化研究结构得到了一系列强大的教学课程和研讨会系列的支持 旨在介绍和完善博士后学员所需的理解、设计、写作、 为再生医学研究项目承担并获得校外财政支持。增加 重点将放在让博士生接触高度相关的临床挑战和接触 外科医生科学家致力于再生骨科医学领域的基础研究。 T32研究和 教学培训计划旨在为个别受训者提供 2-3 年的资助，为他们的学习做好准备 他们过渡到更专业的培训并作为指导支持的来源，以扩展 超出 T32 的任命期限。