Contingency Management Treatment of Alcohol Abuse American Indian People

酗酒的应急管理治疗美洲印第安人

• 批准号: 8729436
• 负责人: DEDRA S BUCHWALD
• 金额: $ 60.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8729436
• 关键词: Abstinence; Address; Adult; Affect; Aftercare; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; American Indian and Alaska Native; American Indians; Behavior Control; Behavior Therapy; Biological Markers; Breath Tests; Clinical; Communities; Comorbidity; Complex; Control Groups; Dependence; Drops; Drug abuse; Drug usage; Ensure; Ethnic Origin; Ethnic group; Evidence based treatment; Face; Fetal Alcohol Exposure; Glucuronides; HIV risk; Health; Health care facility; Healthcare; High Prevalence; Homelessness; Hopi Tribe of Arizona; Hour; Illicit Drugs; Individual; Intervention; Knowledge; Life; Mails; Measures; Medical; Morbidity - disease rate; Nicotine; Outcome; Participant; Patient Self-Report; Persons; Population; Positioning Attribute; Positive Reinforcements; Poverty; Protocols documentation; Provider; Psychological reinforcement; Public Health; Publishing; Qualitative Research; Race; Randomized; Randomized Controlled Trials; Relative (related person); Research; Research Infrastructure; Research Methodology; Research Personnel; Reservations; Rewards; Risk Behaviors; Rural; Sampling; Services; Severities; Site Visit; Substance abuse problem; Suicide; Teleconferences; Testing; Time; Treatment outcome; Tribes; Unemployment; Urine; Washington; Wyoming; addiction; alcohol abstinence; alcohol abuse therapy; alcohol consequences; alcohol risk; alcohol testing; base; behavioral impairment; breath alcohol measurement; clinical infrastructure; contingency management; conventional therapy; craving; drinking; drug abstinence; experience; follow-up; group intervention; health disparity; improved; innovation; mortality; psychosocial; public health relevance; reduced alcohol use; reinforcer; reservation-based; secondary outcome; standard care; treatment as usual; urban Native American

DESCRIPTION (provided by applicant): A high prevalence of alcohol dependence, compounded by a lack of culturally acceptable treatment options, is one of the most severe health disparities faced by American Indians and Alaska Natives (AI/AN). AI/ANs suffer disproportionately from alcohol dependence and its medical and psychosocial consequences relative to other racial and ethnic groups. AI/ANs are also less likely to receive or complete alcohol treatment relative to Whites. Some treatments for alcohol dependence are effective in non-Native populations, yet little is known about their acceptability and benefit for AI/ANs. One approach to reducing alcohol-associated health disparities is to form partnerships between AI/AN communities, clinicians, and researchers to tailor and test treatments in AI/ANs that have established benefits for other groups. This approach holds promise for developing treatments that are culturally acceptable, effective, sustainable, and portable. Contingency management (CM) is an intervention that offers rewards 2-3 times weekly for drug or alcohol abstinence, typically over 12 weeks of treatment. In non-AI/AN populations, CM is one of the most effective and well-studied behavioral treatments for illicit drug abuse. Compared to standard care, CM has higher rates of 8-week in-treatment abstinence (58 percent vs. 11 percent), 12-month post-treatment abstinence (30 percent vs. 5 percent), and treatment completion (75 percent vs. 40 percent). However, few studies have examined CM for alcohol dependence, primarily because of the lack of a biomarker that can detect alcohol use over more than 2 days (a requirement for CM). We have overcome this critical methodological barrier by using a new and superior measure of recent alcohol consumption, namely, ethyl glucuronide urine tests, which can detect low levels of alcohol use for at least the past 2 days. This approach permits us to implement and accurately evaluate CM for alcohol dependence in AI/AN adults. We propose to conduct a randomized, controlled trial of a culturally-acceptable CM intervention to encourage and support abstinence among AIs from 3 tribes living on 2 reservations and AI/ANs receiving services at an urban Indian healthcare facility. After we utilize qualitative research methods to modify the CM protocol to maximize cultural acceptability in each community, 400 individuals with alcohol dependence will receive treatment-as-usual and take part in a 4-week induction period before randomization either to an intervention consisting of 12 weeks of CM, or to a control condition of treatment as usual and non- contingent rewards. Our specific aims are to 1) maximize the cultural acceptability of the CM intervention; 2) determine if participants randomized to the CM group use less alcohol than those in the control group; 2) quantify group differences in secondary addiction-related outcomes and alcohol-associated health-impairing behaviors; and 3) identify demographic, cultural, and other predictors of treatment outcome in the CM group. Our results will offer definitive evidence on the efficacy of CM as a treatment for alcohol dependence in urban and rural AI/AN populations and build the research and clinical infrastructure of our community partners.

描述（由申请人提供）：酒精依赖的高患病率，加上缺乏文化上可接受的治疗方案，是美洲印第安人和阿拉斯加原住民（AI/AN）面临的最严重的健康差距之一。与其他种族和族裔群体相比，人工智能/人工智能人不成比例地患有酒精依赖及其医疗和心理社会后果。与白人相比，AI/AN也不太可能接受或完成酒精治疗。一些酒精依赖的治疗方法在非土著人群中是有效的，但对AI/AN的可接受性和益处知之甚少。减少酒精相关健康差异的一种方法是在AI/AN社区、临床医生和研究人员之间建立伙伴关系，以定制和测试AI/AN中已为其他群体带来益处的治疗方法。这种方法有望开发出文化上可接受的，有效的，可持续的和便携式的治疗方法。 应急管理（CM）是一种干预措施，每周为药物或酒精戒断提供2-3次奖励，通常超过12周的治疗。在非AI/AN人群中，CM是非法药物滥用最有效和研究最充分的行为治疗方法之一。与标准治疗相比，CM的8周治疗中禁欲率（58%对11%），12个月治疗后禁欲率（30%对5%）和治疗完成率（75%对40%）更高。然而，很少有研究检查CM的酒精依赖，主要是因为缺乏一个生物标志物，可以检测酒精使用超过2天（CM的要求）。我们通过使用一种新的、上级的近期饮酒测量方法，即乙基葡萄糖醛酸苷尿液检测，克服了这一关键的方法学障碍，该方法可以检测出至少过去2天内的低水平饮酒。这种方法使我们能够实施和准确地评估CM在AI/AN成人酒精依赖。我们建议进行一项文化上可接受的CM干预的随机对照试验，以鼓励和支持生活在2个保留地的3个部落的AI和在城市印度医疗机构接受服务的AI/AN之间的禁欲。在我们利用定性研究方法修改CM方案以最大限度地提高每个社区的文化可接受性后，400名酒精依赖者将接受常规治疗，并在随机化之前参加为期4周的诱导期，包括12周的CM干预，或常规治疗和非偶然奖励的对照条件。我们的具体目标是：1）最大限度地提高CM干预的文化可接受性; 2）确定随机分配到CM组的参与者是否比对照组使用更少的酒精; 2）量化继发性成瘾相关结果和酒精相关健康损害行为的组间差异; 3）确定CM组治疗结果的人口统计学，文化和其他预测因素。我们的研究结果将为CM作为城市和农村AI/AN人群酒精依赖治疗的有效性提供明确的证据，并为我们的社区合作伙伴建立研究和临床基础设施。