HIGHLY CUSTOMIZABLE BLACKROCK MICRO MOLDED ARRAYS (BRMMA)

高度可定制的贝莱德微模塑阵列 (BRMMA)

• 批准号: 8453715
• 负责人: Rajmohan Bhandari
• 金额: $ 35万
• 依托单位: BLACKROCK MICROSYSTEMS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8453715
• 关键词: 3-Dimensional; Active Sites; Animal Model; Architecture; Budgets; Characteristics; Communities; Development; Devices; Electrodes; Environment; Glass; Goals; Gold; Laboratories; Laboratory Research; Lead; Location; Marketing; Masks; Mechanics; Michigan; Molds; Neurosciences Research; Polymers; Price; Process; Property; Research; Shapes; Shoes; Silicon; Slice; Solutions; Specific qualifier value; Spectrum Analysis; Surface; Techniques; Technology; Testing; Time; Tissues; Utah; Vertebral column; Work; base; cost; cytotoxicity test; design; electric impedance; flexibility; in vitro testing; in vivo; man; microsystems; novel; public health relevance; relating to nervous system

DESCRIPTION (provided by applicant): In the last two decades though the field of neuroprosthetics has gained tremendous momentum through the development of novel architectures for neural interfaces, however, till date there is no device which can be nomenclatured as the "gold standard" in the field. As a result the research and technology environment at each laboratory is unique and require a high-level of customization and integration. The objective of this application is to devise a "one-in-all technology" that encompasses the assets (such as ultra high aspect ratio, multi- channels, flexible substrate, interconnection etc.) of the silicon (such as the Utah and Michigan array) and polymer based arrays and mitigates their limitations. Most importantly it provides a highly customized and "poor man's solution" to research laboratories. In this application we present a platform technology, called Blackrock Micro Molding Arrays (BRMMA), based on micro molding technique, which enables devolvement of highly customizable and affordable micro devices without compromising the characteristics of the neural probe such as electrical and mechanical properties, reliability, and durability. BRMMA offers highly customized design rules which include surface and penetrating electrodes. It allow the end users for the first time to dictate their own electrode design (specified within the design rules of BRMMA) as per their hypothesis, and choose the number of active channels per shaft, location and material used for active sites, shape and size of the shaft etc. BRMMA developed by Blackrock Microsystems would produce relevant statistical number of devices to test in vitro and in vivo functionality for long term use BRMMA would be marketed to the neuroscience research community by Blackrock Microsystems.

描述（由申请人提供）：在过去的二十年中，虽然神经假体领域通过开发用于神经接口的新型架构获得了巨大的动力，但是，迄今为止，还没有可以被命名为该领域的“黄金标准”的设备。因此，每个实验室的研究和技术环境都是独特的，需要高水平的定制和集成。本申请的目的是设计一种“一体化技术”，包括资产（如超高纵横比、多通道、柔性基板、互连等）。的硅（如犹他州和密歇根州的阵列）和聚合物基阵列，并减轻其局限性。最重要的是，它为研究实验室提供了高度定制的“穷人的解决方案”。在这个应用程序中，我们提出了一个平台技术，称为Blackrock微成型阵列（BRMMA），基于微成型技术，这使得高度可定制的和负担得起的微型设备的发展，而不影响神经探针的特性，如电气和机械性能，可靠性和耐用性。BRMMA提供高度定制的设计规则，包括表面和穿透电极。它首次允许最终用户决定自己的电极设计（在BRMMA的设计规则中规定），并选择每个轴的活动通道数量、位置和用于活动部位的材料，由Blackrock Microsystems开发的BRMMA将产生相关统计数量的器械，以测试长期使用的体外和体内功能BRMMA将由黑石微系统公司向神经科学研究界推销。