An implantable chronic 128 channel macro and micro ECoG system with integrated recording, stimulation, and impedance measuring capabilities

植入式慢性 128 通道宏观和微观 ECoG 系统，具有集成记录、刺激和阻抗测量功能

• 批准号: 9085458
• 负责人: Rajmohan Bhandari
• 金额: $ 34.95万
• 依托单位: BLACKROCK MICROSYSTEMS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9085458
• 关键词: Adult; Aluminum Oxide; Amplifiers; Animal Model; Animals; Architecture; Area; Arts; Back; Biocompatible; Blood Vessels; Chronic; Clinical; Clinical Research; Communities; Custom; Data; Development; Devices; Electrodes; Electronics; Electrophysiology (science); Encapsulated; Engineering; Ensure; Epilepsy; Evaluation; Film; Goals; Health; Histology; Human; Implant; In Situ; In Vitro; Life; Link; Location; Longevity; Maps; Measurement; Measures; Mechanics; Modeling; Monitor; Operative Surgical Procedures; Patients; Phase; Platinum; Polychlorinated Biphenyls; Polymers; Printing; Process; Production; Research; Resistance; Resolution; Safety; Sampling; Shapes; Sheep; Shunt Device; Side; Signal Transduction; Silicones; Site; Skin; Snow; Somatosensory Evoked Potentials; Specificity; Subdural space; Surface; System; Systems Integration; Testing; Thick; Time; Titania; Titanium; Translating; Translations; Wireless Technology; absorption; awake; base; clinical practice; cranium; density; design; digital; electric impedance; flexibility; implantable device; implantation; improved; in vitro testing; in vivo; interest; meetings; microsystems; nervous system disorder; novel; parylene; parylene C; patient safety; signal processing; single photon emission computed tomography; tool

 DESCRIPTION (provided by applicant): The objective of this proposal is to design, develop, and validate a commercially viable "human-use" smart 128-channel macro & micro ECoG microsystem with integrated recording, stimulation, and impedance measuring capabilities for epilepsy monitoring. The microsystem comprises of a state-of-art microelectronic signal processing component linked to a macro & micro integrated ECoG grid via a thin, highly flexible, bio- compatible micro-ribbon cable on one end and a single percutaneous flexible-cable ("pigtail") on the other end. The custom multiplexing ASIC electronics is capable of 128-channel recordings at 16-bit resolution and has fast settle capability (for stimulation option) and patient safety circuitry. The component is contained on a printed circuit board and is encapsulated with Parylene-C and Silicone. The encapsulated microelectronic component unit is encased in a titanium case and resides subcutaneously between the skin and the skull. The integrated microsystem would have unique "snow-flake" shape grid design containing alternate rows of macro and micro channels. The phase-I would target a short-term goal of developing, bench testing and validating in adult sheep model the complete implantable ECoG microsystem that can be translated to research and clinical lab in the shortest time frame.