Characterization of a Novel Diagnostic Test for Pneumococcal Infection

肺炎球菌感染新型诊断测试的表征

• 批准号: 8426114
• 负责人: Frances Eun-Hyung Lee
• 金额: $ 19.79万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8426114
• 关键词: Acute; Adult; Affect; Age; Antibiotic Therapy; Antibiotics; Antigens; Bacteremia; Biological Assay; Blood; Cells; Cellulitis; Cessation of life; Characteristics; Child; Clinical; Communities; Detection; Development; Diagnosis; Diagnostic; Diagnostic Procedure; Diagnostic tests; Disease; Epidemiology; Etiology; Gold; Gram' s stain; Grant; Hospitalization; Illness impact; Immunoglobulin-Secreting Cells; Incidence; Infection; Kinetics; Measures; Methods; Minority; Nasopharynx; Otitis Media; Outcome; Patients; Persons; Pneumococcal Colonization; Pneumococcal Infections; Pneumococcal Pneumonia; Pneumococcal vaccine; Pneumonia; Positive Test Result; Research Personnel; Respiratory Tract Infections; Serologic tests; Sinusitis; Specificity; Sputum; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Syndrome; Testing; Time; Urine; Vaccinated; Work; base; burden of illness; clinical epidemiology; clinical practice; diagnosis standard; diagnostic accuracy; efficacy trial; epidemiology study; improved; microbial; novel; novel diagnostics; pathogen; respiratory virus; response; routine Bacterial stain; study characteristics; tool; vaccine efficacy

DESCRIPTION (provided by applicant): Streptococcus pneumoniae is generally considered the most common bacterial cause of community acquired pneumonia, responsible for 350,000-620,000 hospitalizations each year in the US among patients above age 65 years. Globally, invasive pneumococcal disease affects an estimated 1.6 million people annually with over 1 million deaths, many of them children. To appropriately treat microbial infections, accurate diagnosis is essential; however, current methods of diagnosing pneumococcal disease are very limited resulting in gross underestimates of this disease. We have developed a novel diagnostic test using highly specialized cells found in the blood during acute infections: "antibody secreting cells". The ability to accurately diagnose S. pneumoniae infection early in the illness at a time when management decisions are being considered would be a significant advance. This grant will study the antibody secreting cells as a novel test during acute pneumococcal infections.

描述（由申请方提供）：肺炎链球菌通常被认为是社区获得性肺炎的最常见细菌原因，在美国，每年有350，000 - 620，000例65岁以上患者住院。在全球范围内，侵袭性肺炎球菌疾病每年影响约160万人，死亡人数超过100万，其中许多是儿童。为了适当地治疗微生物感染，准确的诊断是必不可少的;然而，目前诊断肺炎球菌疾病的方法非常有限，导致严重低估了这种疾病。我们开发了一种新的诊断测试，使用在急性感染期间血液中发现的高度专业化的细胞：“抗体分泌细胞”。准确诊断S.在考虑管理决策的时候，在疾病的早期发现肺炎感染将是一个重大的进步。这项资助将研究抗体分泌细胞作为急性肺炎球菌感染的一种新的检测方法。