Immune Mechanisms of Severe RSV Disease- T Cell and Antibody Responses

描述（由申请方提供）：呼吸道合胞病毒（RSV）可导致老年人严重疾病。老年人严重疾病的发病机制可能是多因素的，但衰老免疫反应的失调是理解疾病严重程度的核心。与其他病毒不同，RSV具有1型和2型应答的证据。类型1应答包括IFNg和IL-12，它们在病毒清除中是重要的。2型应答包括IL-4、IL-5和IL-10分泌，并且在抗寄生虫应答、变态反应和有力的抗体产生中是重要的。我们最近证明，RSV特异性IL-5（2型）反应在活动性感染与症状的严重程度在年轻和中年人。我们相信RSV-IL-5应答将在老年人RSV疾病的严重程度中发挥重要作用。与年轻人相比，对感染的RSV特异性抗体反应增加。我们建议研究的作用，以及2型细胞因子和有力的抗体反应之间的潜在联系，在老年人在RSV感染。我们研究的目的是为老年人严重RSV疾病的预防和治疗提供见解。

DESCRIPTION (provided by applicant): Respiratory Syncytial Virus (RSV) causes severe disease in the elderly. The pathogenesis of severe disease in the elderly is probably multi-factorial but the dysregulation of the aging immune response is central to understanding disease severity. Unlike other viruses, RSV has evidence of typel and type2 responses. Typel responses include IFNg and IL-12 which are important in viral clearance. Type2 responses include IL-4, IL-5, and IL-10 secretion and are important in anti-parasitic responses, allergy and vigorous antibody production. We recently demonstrate that RSV-specific IL-5 (type2) responses during active infection correlate with symptom severity in young and middle-aged adults. We believe that RSV-IL-5 responses will play an important role in RSV disease severity in the elderly. RSV-specific antibody responses to infection are increased compared to young adults. We propose to study the role as well as the potential links between type2 cytokines and vigorous antibody responses in the elderly during RSV infection. The goal of our studies is to provide insights in prevention and treatment of severe RSV disease in the elderly.