NUTRITION STUDY FOR YOUNG ADULTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究的目的是在一项为期18个月的随机对照试验中，对18至35岁的年轻人进行低血糖指数饮食(实验)和对照饮食的效果比较。 他们的假设是，与接受标准饮食的人相比，接受低血糖指数饮食的肥胖者18个月后体脂较低，胰岛素抵抗减少，心血管疾病(CVD)风险因素得到改善。 这项研究是一项前瞻性随机对照试验(RCT)，有两个治疗臂。在基线测量之后，90名受试者将随机接受降低血糖负荷(试验性)饮食或降低脂肪(常规)饮食。所有受试者将在为期6个月的强化干预期内接受集体营养教育和个人饮食咨询会议，并进行18个月的随访。在头6个月期间将举行14次会议，在12个月的后续期间将举行4次会议。从基线到18个月的体脂百分比变化是主要终点；其他结果测量包括胰岛素抵抗和心血管疾病(CVD)风险因素。对饮食治疗的依从性将通过多次24小时饮食召回进行评估。体力活动将使用计步器和24小时回忆方法进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to compare the effects of a low glycemic index (experimental) diet with those of a control diet among young adults ages 18 to 35 years in an 18-month randomized controlled trial. They hypothesis is that obese subjects receiving a low glycemic index diet will have lower body fat, decreased insulin resistance, and improvements in cardiovascular disease (CVD) risk factors after 18 months, compared with those receiving a standard diet. The study is a prospective, randomized controlled trial (RCT) with two treatment arms. Following baseline measurements, 90 subjects will be randomized to receive either a reduced glycemic load (experimental) diet or a reduced fat (conventional) diet. All subjects will receive group nutrition education and individual dietary counseling sessions during an intensive 6-month intervention period, with follow-up through 18 months. There will be 14 sessions during the first 6 months and 4 sessions during the 12-month follow-up period. Change in percent body fat from baseline to 18 months constitutes the primary endpoint; other outcome measures include insulin resistance and cardiovascular disease (CVD) risk factors. Compliance with dietary treatments will be assessed by multiple 24-hour dietary recalls. Physical activity will be assessed using a pedometer, as well as 24-hour recall methodology.