Development of a High Performance Bioprocess for Eliminating 1,4-Dioxane in Water

开发消除水中 1,4-二恶烷的高性能生物工艺

• 批准号: 8648317
• 负责人: Joseph Salanitro
• 金额: $ 106.85万
• 依托单位: MICROVI BIOTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-18 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8648317
• 关键词: Address; Adhesives; Biodegradation; Biological; Biological Availability; Biological Sciences; Bioreactors; Capital; Carcinogens; Chemicals; Cost Analysis; Coupled; Data; Development; Dioxanes; Economics; Effectiveness; Environmental sludge; Evaluation; Funding; Generations; Health; Human; Hydrogen Peroxide; Investigation; Kinetics; Life Stress; Link; Measures; Methods; Michigan; Oils; Outcome; Ozone; Paint; Performance; Pesticides; Pharmacologic Substance; Phase; Plant Resins; Plastics; Printing; Procedures; Process; Production; Public Health; Pump; Research; Resources; Rhodococcus; Risk; Route; Safety; Salts; Science; Site; Solvents; Source; Stream; Structure; Technology; Technology Assessment; Testing; Travel; United States; Varnish; Water; Water Supply; Waxes; Work; base; biological systems; bioprocess; comparative; cost; cost effective; density; design; drinking water; high risk; innovation; meetings; microorganism; new technology; novel; operation; oxidation; programs; prototype; public health relevance; remediation; response; restoration; superfund site; tool; wasting; water treatment

Project Summary / Abstract Across the United States, water suppliers and managers are finding dangerous levels of 1,4-dioxane in water. This compound has been used for decades in a wide range of applications including as (1) a solvent in paints, varnishes, and prints; (2) treatment agent in artificial leather; (3) ingredient in pesticides and fumigants; (4) purifying agent in pharmaceuticals; and (5) solvent in resins, oils, plastics, adhesives, waxes, and cement. 1,4-dioxane is a probable human carcinogen at extremely low levels in water (parts-per-billion). It is highly soluble and thus travels extensively in water. Most importantly, few conventional water treatment technologies can remove 1,4-dioxane from water. There are only two current routes of eliminating 1,4-dioxane in water: UV or hydrogen peroxide coupled with ozone oxidation (i.e. advanced oxidation), and biological degradation. The energy and chemical costs of UV and chemical oxidation processes are often prohibitively high. There is also a significant risk of producing harmful by-products (such as carcinogenic bromate) and these technologies have limited applicability in certain circumstances such as high levels of inorganic salts. Biological degradation alternatively suffers from a number of drawbacks, including process stability, the need to induce degradation, limited performance, clogging, performance sensitivity, and the production of sludge or secondary waste streams. If these problems can be overcome, however, biological treatment offers a promising method of completely degrading 1,4-dioxane into harmless products and protecting public health. This Phase II demonstration proposal is based on successful Phase I results showing the feasibility of a new biological approach. In Phase I, a technology was designed and tested for 1,4-dioxane degradation that does not require pre-induction and can be applied using a new high performance bioprocess. The prototype developed in the Phase I work will be scaled and piloted at an actual contaminated site. The pilot will seek to establish performance and operational parameters of the new technology, evaluate long-term and sustainable operation, and address parameters informing a technoeconomic analysis. The major outcome of this Phase II effort will be the demonstration and full characterization of a first-of-its-kind high performance bioprocess for eliminating 1,4-dioxane in water resources. The technology's intended value proposition includes simple operation, rapid and effective degradation, wide applicability to a range of water sources, reliable performance, and lower overall costs compared to existing methods, especially chemical oxidation. Most importantly, the Phase II funding will provide a valuable tool for protecting and remediating drinking water supplies, thus safeguarding public and safety, and environmental sustainability for generations to come.

项目概要/摘要 美国各地的供水商和管理者发现水中 1,4-二恶烷含量达到危险水平。 这种化合物几十年来一直在广泛的应用中使用，包括作为 (1) 油漆中的溶剂， 清漆和印刷品； (2)人造革中的处理剂； （三）农药、熏蒸剂成分； (4) 医药净化剂； (5) 树脂、油、塑料、粘合剂、蜡和水泥中的溶剂。 1,4-二恶烷是一种可能的人类致癌物，在水中含量极低（十亿分之一）。它是高度 易溶于水，因此可以在水中广泛传播。最重要的是，传统的水处理技术很少 可去除水中的1,4-二恶烷。目前消除水中 1,4-二恶烷的途径只有两种： 紫外线 或过氧化氢与臭氧氧化（即高级氧化）和生物降解相结合。这 紫外线和化学氧化过程的能源和化学品成本通常高得令人望而却步。还有一个 产生有害副产品（例如致癌的溴酸盐）的重大风险，并且这些技术已经 在某些情况下适用性有限，例如无机盐含量高。 生物降解也存在许多缺点，包括过程稳定性、需要 引起降解、性能受限、堵塞、性能敏感性以及污泥或污泥的产生 二次废物流。然而，如果这些问题能够得到克服，生物治疗将提供一个解决方案。 这是一种将 1,4-二恶烷完全降解为无害产品并保护公众健康的有希望的方法。 该第二阶段示范提案基于第一阶段的成功结果，显示了新方法的可行性 生物学方法。在第一阶段，设计并测试了一项用于 1,4-二恶烷降解的技术，该技术 不需要预诱导，并且可以使用新的高性能生物工艺来应用。原型机 第一阶段工作中开发的产品将在实际污染场地进行规模化和试点。试点项目将寻求 建立新技术的性能和操作参数，评估长期和可持续的 操作和地址参数为技术经济分析提供信息。 第二阶段工作的主要成果将是首创的演示和全面表征 用于消除水资源中 1,4-二恶烷的高性能生物工艺。技术的预期价值 主张包括操作简单、降解快速有效、对各种水体的广泛适用性 与现有方法（尤其是化学方法）相比，来源丰富，性能可靠，总体成本更低 氧化。最重要的是，第二阶段的资金将为保护和修复提供宝贵的工具 饮用水供应，从而保障公众和安全以及世世代代的环境可持续性 来。