Investigation of the mechanism by which medium chain fatty acids prevent the development of obesity and insulin resistance - what role for GPR84?

研究中链脂肪酸预防肥胖和胰岛素抵抗发展的机制 - GPR84 有何作用？

• 批准号: nhmrc : 1061804
• 负责人: A/Pr Nigel Turner
• 金额: $ 34.18万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/investigation-mechanism-medium-role-gpr84/454935
• 关键词: Investigation; mechanism; medium; chain; fatty

Medium chain fatty acids do not induce the same degree of obesity and insulin resistance as long chain fatty acids and this is due to changes in metabolism in skeletal muscle and adipose tissue. In this proposal we will investigate whether medium chain fatty acids induce their beneficial effects by interacting with a specific G protein-coupled receptor named GPR84. This receptor may be a new therapeutic target for the treatment of metabolic diseases.

中链脂肪酸不诱导与长链脂肪酸相同程度的肥胖和胰岛素抵抗，这是由于骨骼肌和脂肪组织中代谢的变化。在这项提案中，我们将研究中链脂肪酸是否通过与一种名为GPR84的特异性G蛋白偶联受体相互作用来诱导其有益作用。该受体可能成为代谢性疾病治疗的新靶点。