Mitochondrial sirtuins, energy metabolism and insulin action

线粒体 Sirtuins、能量代谢和胰岛素作用

• 批准号: nhmrc : 1043779
• 负责人: A/Pr Nigel Turner
• 金额: $ 38.87万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mitochondrial-sirtuins-energy-insulin-action/111603
• 关键词: Mitochondrial; sirtuins; energy; metabolism; insulin

Post-translational modification of lysine residues has a major influence on protein function. Many mitochondrial proteins are affected by lysine modifications and recent work has described a role for sirtuin enzymes in regulating these processes. This proposal will investigate whether targeted increases in sirtuin activity can improve mitochondrial function and insulin action in mouse models of obesity and insulin resistance.

赖氨酸残基的翻译后修饰对蛋白质功能具有重要影响。许多线粒体蛋白受到赖氨酸修饰的影响，最近的工作描述了沉默调节蛋白酶在调节这些过程中的作用。该提案将研究是否有针对性地增加sirtuin活性可以改善肥胖和胰岛素抵抗小鼠模型的线粒体功能和胰岛素作用。