Mitochondrial Energy Metabolism and Insulin Action

线粒体能量代谢和胰岛素作用

• 批准号: nhmrc : 481356
• 负责人: A/Pr Nigel Turner
• 金额: $ 25.38万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mitochondrial-energy-metabolism-insulin-action/115399
• 关键词: Mitochondrial; Energy; Metabolism; Insulin; Action

Obesity and type 2 diabetes are two major health conditions associated with abnormal energy metabolism. In this proposal I will investigate the role of important metabolic proteins in regulating energy expenditure and insulin action in skeletal muscle and adipose tissue, two crucial tissues for whole-body energy metabolism. These studies will provide critical insight into the factors leading to obesity and type 2 diabetes and will assist in identifying possible therapeutic targets.

肥胖和 2 型糖尿病是与能量代谢异常相关的两种主要健康状况。在本提案中，我将研究重要的代谢蛋白在调节骨骼肌和脂肪组织（全身能量代谢的两个关键组织）的能量消耗和胰岛素作用中的作用。这些研究将为导致肥胖和 2 型糖尿病的因素提供重要见解，并有助于确定可能的治疗靶点。