NAD+ and SIRT2 regulation of mitotic lifespan, senescence and healthy ageing

NAD 和 SIRT2 对有丝分裂寿命、衰老和健康衰老的调节

• 批准号: nhmrc : 1066172
• 负责人: A/Pr Nigel Turner
• 金额: $ 41.16万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nad-sirt2-regulation-healthy-ageing/455221
• 关键词: NAD+; SIRT2; regulation; mitotic; lifespan

During youth, cells in our body undergo a continual process of self-renewal, known as mitosis, where cells divide and accurately provide equal number of chromosomes into each daughter cell. During old age, dysfunctional mitosis leads to senescence, where cells no longer divide, and are unable to renew old tissue. We have uncovered a new molecular pathway involving the enzyme SIRT2 that maintains healthy mitosis, and will determine if targeting this pathway preserves health into old age, and ultimately extends lifespan

在青年时期，我们身体中的细胞经历一个持续的自我更新过程，称为有丝分裂，细胞分裂并准确地为每个子细胞提供相等数量的染色体。在老年，有丝分裂功能障碍导致衰老，细胞不再分裂，无法更新旧组织。我们已经发现了一种新的分子途径，涉及维持健康有丝分裂的酶SIRT 2，并将确定靶向该途径是否可以保持健康到老年，并最终延长寿命