NAD+ and SIRT2 regulation of mitotic lifespan, senescence and healthy ageing

在年轻时期，我们体内的细胞经历了一个持续的自我更新过程，称为有丝分裂，在这个过程中，细胞分裂并准确地为每个子细胞提供相同数量的染色体。在老年，功能失调的有丝分裂会导致衰老，细胞不再分裂，无法更新旧组织。我们已经发现了一种新的分子途径，涉及到维持健康有丝分裂的SIRT2酶，并将确定以这一途径为靶点是否能将健康保存到老年，并最终延长寿命

During youth, cells in our body undergo a continual process of self-renewal, known as mitosis, where cells divide and accurately provide equal number of chromosomes into each daughter cell. During old age, dysfunctional mitosis leads to senescence, where cells no longer divide, and are unable to renew old tissue. We have uncovered a new molecular pathway involving the enzyme SIRT2 that maintains healthy mitosis, and will determine if targeting this pathway preserves health into old age, and ultimately extends lifespan