The role of oxyterol-binding protein-related protein 5 (ORP5) in cellular lipid storage and whole body energy homeostasis

氧特醇结合蛋白相关蛋白 5 (ORP5) 在细胞脂质储存和全身能量稳态中的作用

• 批准号: nhmrc : 1144726
• 负责人: A/Pr Nigel Turner
• 金额: $ 51.28万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-oxyterol-binding-energy-homeostasis/1320256
• 关键词: role; oxyterol; binding; protein; related

Fat is stored in the form of lipid droplets in our cells and body. However, our knowledge on how lipid droplets grow and are broken down is very limited. We aim to investigate how lipids are delivered to the lipid droplets and how lipid droplets can store lipids efficiently. Results from the proposed work will provide fundamental new knowledge on how our cells store and utilize fat. Such knowledge may be translated into therapeutic strategies one day against obesity and diabetes.

脂肪以脂滴的形式储存在我们的细胞和身体中。然而，我们对脂滴如何生长和分解的知识非常有限。我们的目的是研究脂质是如何传递到脂滴和脂滴如何有效地储存脂质。这项研究的结果将为我们的细胞如何储存和利用脂肪提供基础性的新知识。这些知识有一天可能转化为治疗肥胖和糖尿病的治疗策略。