Health and lifespan regulation by NAD+ and SIRT2

NAD 和 SIRT2 调节健康和寿命

• 批准号: nhmrc : GNT1066172
• 负责人: A/Pr Nigel Turner
• 金额: $ 39.69万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/health-lifespan-regulation-nad-sirt2/1344903
• 关键词: Health; lifespan; regulation; NAD+; SIRT2

During youth, cells in our body undergo a continual process of self-renewal, known as mitosis, where cells divide and accurately provide equal number of chromosomes into each daughter cell. During old age, dysfunctional mitosis leads to senescence, where cells no longer divide, and are unable to renew old tissue. We have uncovered a new molecular pathway involving the enzyme SIRT2 that maintains healthy mitosis, and will determine if targeting this pathway preserves health into old age, and ultimately extends lifespan

在年轻时期，我们体内的细胞经历了一个持续的自我更新过程，称为有丝分裂，在这个过程中，细胞分裂并准确地为每个子细胞提供相同数量的染色体。在老年时期，功能失调的有丝分裂导致衰老，细胞不再分裂，不能更新旧组织。我们已经发现了一种新的分子途径，涉及SIRT2酶维持健康的有丝分裂，并将确定靶向这一途径是否能保持健康直至老年，并最终延长寿命