项目 2：妊娠中期接触 EDC 及其对胎盘发育的影响-猫眼课题宝

项目 2：妊娠中期接触 EDC 及其对胎盘发育的影响

批准号：

8875688

负责人：

Tracey J. Woodruff

金额：

$13.82万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

依托单位国家：

美国

项目类别：

财政年份：

--

资助国家：

美国

项目状态：

已结题

起止时间：

至 2016-05-31

来源：

https://reporter.nih.gov/project-details/8875688

关键词：

Adult Adverse effects Affect Biological Biological Monitoring Birth Weight Blood Cell model Chemical Actions Chemical Exposure Chemicals Child Childhood Clinical Communities Community Outreach Data Development Dose Endocrine Disruptors Epidemiology Exposure to Fetal Growth Fetal Liver Fetus Goals Growth Growth and Development function Health Human In Vitro Individual Lead Liver Maternal Exposure Measurement Measures Methods Outcome Perinatal Exposure Placenta Placentation Policies Population Study Pre-Eclampsia Pregnancy Pregnancy Trimesters Pregnant Women Premature Birth Public Policy Research Research Project Grants Risk Risk Assessment Risk Factors Sample Size Sampling Specimen Stem cells Techniques Termination of pregnancy Testing Time Translating Translations Umbilical Cord Blood Undifferentiated Work base bisphenol A embryo/fetus environmental chemical environmental chemical exposure fetal human data improved in utero innovation insight liquid chromatography mass spectrometry maternal cigarette smoking maternal serum molecular marker novel organic acid phenyl ether prenatal prevent research study self-renewal trophoblast

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Specific Aims: Research Project 2 tests the hypotheses that polybrominated diphenyl ethers (PBDEs), perfluorinated chemicals (PFCs) and environmental organic acids (EOAs) accumulate differently in human fetuses than in pregnant women during mid-gestation, and that these chemical exposures negatively impact placental development and function, important outcomes that can adversely affect in utero growth and development. Accordingly, the goal is to compare 2nd trimester maternal serum, placenta and fetal liver levels of PBDEs, PFCs and select EOAs through traditional and novel biomonitoring approaches (Aim 1); and evaluate the relationship between these chemical exposures and disruptions of placental development by analyzing morphological and molecular markers of trophoblast differentiation and function (Aim 2).

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Administrative Core

批准号：

10382449
项目类别：
资助金额：

$20.12万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

UCSF Environmental Research and Translation for Health Center (EaRTH Center)

批准号：

10382448
项目类别：
资助金额：

$131.63万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

UCSF Environmental Research and Translation for Health Center (EaRTH Center)

批准号：

9918111
项目类别：
资助金额：

$121.23万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

UCSF Environmental Research and Translation for Health Center (EaRTH Center)

批准号：

10598480
项目类别：
资助金额：

$131.45万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Administrative Core

批准号：

9918112
项目类别：
资助金额：

$17.7万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Administrative Core

批准号：

10598481
项目类别：
资助金额：

$20.55万
财政年份：

2020
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL)

批准号：

10587408
项目类别：
资助金额：

$59.41万
财政年份：

2016
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs

批准号：

9768469
项目类别：
资助金额：

$102.58万
财政年份：

2016
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs

批准号：

9355643
项目类别：
资助金额：

$57.64万
财政年份：

2016
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs

批准号：

9157911
项目类别：
资助金额：

$59.16万
财政年份：

2016
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

批准号：

9079471
项目类别：
资助金额：

$61.67万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

批准号：

8512937
项目类别：
资助金额：

$63.71万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

批准号：

8677893
项目类别：
资助金额：

$61.93万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Human Maternal/Fetal Exposures to PBDEs and their Metabolites During Development

批准号：

8583290
项目类别：
资助金额：

$14.8万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center

批准号：

9320022
项目类别：
资助金额：

$61.29万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Human Maternal/Fetal Exposures to PBDEs and their Metabolites During Development

批准号：

8712486
项目类别：
资助金额：

$11.06万
财政年份：

2013
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Core A: Administrative Core

批准号：

8225475
项目类别：
资助金额：

$3.88万
财政年份：

2011
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Core B: Community Outreach and Translation Core

批准号：

8225476
项目类别：
资助金额：

$3.87万
财政年份：

2011
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Project 1: Assessing Maternal & Fetal Exposure to Chemical During the Second

批准号：

8225472
项目类别：
资助金额：

$1.85万
财政年份：

2011
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Core B: Community Outreach and Translation Core

批准号：

7881034
项目类别：
资助金额：

$4.34万
财政年份：

2010
负责人：

Tracey J. Woodruff
依托单位：

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

海外基金