Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL)

揭示不同产前人群的环境化学暴露及其与孕产妇和围产期健康的关系 (REVEAL)

基本信息

项目摘要

ABSTRACT - Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL) Our renewal application builds on our original R01 by advancing analytical chemistry and computational techniques to characterize more fully the prenatal chemical exposome and its links to adverse maternal and perinatal health outcomes (e.g., gestational diabetes, preterm birth, and low birthweight). Prevalence of these outcomes has increased and is linked to chemical exposures in the US population. Prenatal exposures to a broad range of environmental chemicals, including plastic related chemicals and per- and polyfluoroalkyl substances (PFAS), have been shown to adversely affect health, but technological challenges have left significant data gaps hindering our ability to characterize environmental exposures and drivers of disease. Over 350,000 chemicals and compound mixtures are registered for production worldwide, and thousands of high–production volume chemicals are used extensively in the US, yet human biomonitoring capacity covers a very small fraction of the chemical exposome. In our previous R01 we pioneered a nontargeted analysis (NTA) workflow, with significantly improved computational and analytical methods using high-resolution mass spectrometry (HRMS) in a demographically diverse population of maternal-newborn pairs. We were the first to identify multiple chemicals in maternal and newborn sample used in high volumes in the US not previously detected in human blood samples including chemicals used in personal care products and fragrances, production of plastics, surfactants, and stain treatment. We also identified over 50 novel chemicals with limited to no information on their uses or sources and found significant associations between exogenous and endogenous compounds, several chemical groups (siloxanes, PFAS, and chemicals used in plastics and rubber) and biomarkers of lipid metabolism and regulation, supporting a link to gestational diabetes. For our renewal project, we propose to expand our study population by analyzing an additional 750 2nd trimester pregnancy samples, 300 of the samples matched to our original 3rd trimester samples. We will contribute to improved understanding of the prenatal chemical exposome by integrating NTA with improved computational methods including a chemical suspect database ~1,000,000 exogenous and endogenous chemical features in combination with upgraded software for supercomputing to identify ~500 chemical prenatal exposures and estimate their concentrations using new machine learning algorithms. We will use this data to characterize complex relationships between multiple exogenous chemical exposures, endogenous effect biomarkers, and maternal and perinatal health outcomes. The overarching goal of this renewal is to develop an integrated package of analytic and computational tools that allow expanded capacity to identify and calculate chemical concentrations and their link to adverse maternal and pregnancy outcomes, critical to information public health interventions to prevent harmful chemical exposures.
摘要-揭示环境化学暴露在不同的产前人群和

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites.
  • DOI:
    10.1038/s41598-021-87070-9
  • 发表时间:
    2021-04-07
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Bessonneau V;Gerona RR;Trowbridge J;Grashow R;Lin T;Buren H;Morello-Frosch R;Rudel RA
  • 通讯作者:
    Rudel RA
Translating community-based participatory research into broadscale sociopolitical change: insights from a coalition of women firefighters, scientists, and environmental health advocates.
  • DOI:
    10.1186/s12940-023-01005-7
  • 发表时间:
    2023-08-30
  • 期刊:
  • 影响因子:
    6
  • 作者:
    Ohayon, Jennifer Liss;Rasanayagam, Sharima;Rudel, Ruthann A.;Patton, Sharyle;Buren, Heather;Stefani, Tony;Trowbridge, Jessica;Clarity, Cassidy;Brody, Julia Green;Morello-Frosch, Rachel
  • 通讯作者:
    Morello-Frosch, Rachel
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Tracey J. Woodruff其他文献

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity
分析高通量检测数据以推进环境化学品对人类生殖毒性的快速筛查
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Julia R. Varshavsky;Juleen Lam;Courtney Cooper;Patrick Allard;J. Fung;Ashwini Oke;Ravinder Kumar;Joshua F. Robinson;Tracey J. Woodruff
  • 通讯作者:
    Tracey J. Woodruff
Authors’ rebuttal to Integrated Risk Information System (IRIS) response to “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools”
  • DOI:
    10.1186/s13643-022-01894-8
  • 发表时间:
    2022-03-23
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Stephanie M. Eick;Dana E. Goin;Juleen Lam;Tracey J. Woodruff;Nicholas Chartres
  • 通讯作者:
    Nicholas Chartres
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
  • DOI:
    10.1016/j.envint.2024.109227
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    9.700
  • 作者:
    Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium
  • 通讯作者:
    for the ECHO Cohort Consortium
A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors—implications for research on perinatal outcomes in the ECHO program
对孕产妇产前暴露于环境化学物质和心理社会应激源的综述——对 ECHO 项目围产期结局研究的启示
  • DOI:
    10.1038/s41372-019-0510-y
  • 发表时间:
    2019-10-15
  • 期刊:
  • 影响因子:
    2.400
  • 作者:
    Amy M. Padula;Catherine Monk;Patricia A. Brennan;Ann Borders;Emily S. Barrett;Cindy T. McEvoy;Sophie Foss;Preeya Desai;Akram Alshawabkeh;Renee Wurth;Carolyn Salafia;Raina Fichorova;Julia Varshavsky;Amii Kress;Tracey J. Woodruff;Rachel Morello-Frosch
  • 通讯作者:
    Rachel Morello-Frosch
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
美国评估化学暴露与儿童健康的机会:儿童健康结果的环境影响(ECHO)计划
  • DOI:
    10.1038/s41370-020-0211-9
  • 发表时间:
    2020-02-17
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    Jessie P. Buckley;Emily S. Barrett;Paloma I. Beamer;Deborah H. Bennett;Michael S. Bloom;Timothy R. Fennell;Rebecca C. Fry;William E. Funk;Ghassan B. Hamra;Stephen S. Hecht;Kurunthachalam Kannan;Ramsunder Iyer;Margaret R. Karagas;Kristen Lyall;Patrick J. Parsons;Edo D. Pellizzari;Antonio J. Signes-Pastor;Anne P. Starling;Aolin Wang;Deborah J. Watkins;Mingyu Zhang;Tracey J. Woodruff
  • 通讯作者:
    Tracey J. Woodruff

Tracey J. Woodruff的其他文献

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{{ truncateString('Tracey J. Woodruff', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10382449
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    10382448
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    9918111
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    10598480
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    9918112
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10598481
  • 财政年份:
    2020
  • 资助金额:
    $ 59.41万
  • 项目类别:
Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs
在不同母婴群体中发现新型环境化学物质
  • 批准号:
    9768469
  • 财政年份:
    2016
  • 资助金额:
    $ 59.41万
  • 项目类别:
Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs
在不同母婴群体中发现新型环境化学物质
  • 批准号:
    9355643
  • 财政年份:
    2016
  • 资助金额:
    $ 59.41万
  • 项目类别:
Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs
在不同母婴群体中发现新型环境化学物质
  • 批准号:
    9157911
  • 财政年份:
    2016
  • 资助金额:
    $ 59.41万
  • 项目类别:
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
加州大学旧金山分校怀孕期接触环境化学品 (PEEC) 儿童中心
  • 批准号:
    9079471
  • 财政年份:
    2013
  • 资助金额:
    $ 59.41万
  • 项目类别:

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