UCSF Environmental Research and Translation for Health Center (EaRTH Center)

加州大学旧金山分校健康中心环境研究与翻译（EaRTH 中心）

• 批准号: 10382448
• 负责人: Tracey J. Woodruff
• 金额: $ 131.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-22 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10382448
• 关键词: Address; Affect; Analytical Chemistry; Animal Model; Bioinformatics; Biological; Biological Assay; Biomedical Research; California; Cell Nucleus; Cell model; Chemical Exposure; Chemicals; Child; Chronic Disease; Clinical; Clinical Medicine; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Community Outreach; Complex; Consultations; Core Facility; Data; Dentistry; Development; Diabetes Mellitus; Discipline; Disease; Educational Curriculum; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Exposure to; Family; Funding; Future; Goals; Health; Health Professional; Health Sciences; Healthcare; Human; Infrastructure; Institution; International; Intervention; Investigation; Laboratories; Leadership; Link; Location; Longevity; Malignant Neoplasms; Measurement; Measures; Mediating; Medical; Medical Students; Medicine; Mentors; Mentorship; Modeling; National Institute of Environmental Health Sciences; Neurodevelopmental Disorder; Obesity; Pathway interactions; Patients; Peer Review; Pharmacy facility; Pilot Projects; Planet Earth; Positioning Attribute; Prevalence; Prevention; Prevention education; Production; Proteomics; Publishing; Reproduction; Reproductive Health; Research; Research Design; Research Personnel; Resources; Role; San Francisco; School Nursing; Schools; Science; Scientist; Students; Technology; Training; Translating; Translational Research; Translations; Underserved Population; Universities; Vulnerable Populations; Women' s Health; Work; career; community engagement; data integration; education resources; environmental chemical; environmental stressor; health data; health literacy; healthcare community; high throughput screening; human tissue; improved; in vivo; insight; interdisciplinary collaboration; member; men; next generation; operation; outreach; prevent; programs; ranpirnase; reproductive; social stressor; tool

The overall goal of the new University of California, San Francisco (UCSF) Environmental Research and Translation for Health (EaRTH) Center is to accelerate the pace of recognizing and preventing environmental exposures that affect reproduction and development to improve human health across the lifespan. Addressing the complex problems of environmental health requires partnerships across disciplines; mobilization of technology for identification, intervention, and prevention; and education of future scientists and clinicians and the public. The EaRTH Center is uniquely positioned to address these challenges and advance environmental health. By virtue of its location at UCSF—a premier institution for biomedical research, translation of research findings, and clinical training—and its strong interdisciplinary team, the EaRTH Center will fill a critical gap in a prominent clinical and biomedical research setting. Our proposed UCSF P30 EaRTH Center will allow us to: create opportunities for new research directions in environmental health at UCSF that are not currently possible; nurture and sustain transdisciplinary research collaborations across a network of academics and diverse UCSF departments to advance our understanding of the relationship between environment and disease; mentor and grow the next generation of research and clinical leaders in environmental health; and embed environmental health literacy within health care to accelerate prevention of environmentally mediated diseases. Our Center tightly integrates 4 cores and 1 program: 1) an Administrative Core to provide leadership, infrastructure, administrative and communication support, advice and oversight to coordinate all EaRTH Center operations; 2) an Integrated Health Sciences Facility Core (IHSFC) that will provide consultation on study design, data integration, data of environmental and social stressors, and translation and dissemination of research findings; 3) a Bioassay Facility Core that will provide state-of-the-art tools for measuring chemical exposures and their effects on biological pathways; 4) a Community Engagement Core (CEC) to expand environmental health education and resources for students and health professionals to embed environmental health within health care; and 5) a Pilot Project Program to fund transdisciplinary projects enabling researchers to enter the field or add an environmental component to their current research. Our integrated Center will lead to new scientific understandings in environmental health tightly linked to our community outreach work, which will shift the fundamental understanding of the role of environment in disease, leading to solutions to preventing harmful exposures and improving health.

新的加州大学弗朗西斯科分校（UCSF）环境研究的总体目标 和翻译健康（EaRTH）中心是为了加快认识和预防的步伐， 影响生殖和发育的环境暴露，以改善整个生命周期的人类健康。 解决复杂的环境卫生问题需要跨学科的伙伴关系;动员 识别、干预和预防技术;教育未来的科学家和临床医生， 公众EaRTH中心具有独特的定位，以应对这些挑战，并推进环境 健康凭借其在UCSF的位置-生物医学研究的首要机构，研究翻译 研究结果和临床培训-及其强大的跨学科团队，EaRTH中心将填补一个关键的空白， 突出的临床和生物医学研究环境。我们建议的UCSF P30 EaRTH中心将允许我们： 为加州大学旧金山分校环境健康领域的新研究方向创造目前不可能的机会; 培养和维持跨学科的研究合作，在学术网络和不同的UCSF 部门，以促进我们对环境和疾病之间的关系的理解;导师和 培养下一代环境健康研究和临床领导者; 在卫生保健中普及卫生知识，以加速预防环境介导的疾病。我们中心 紧密集成了4个核心和1个程序：1）一个管理核心，提供领导力、基础设施， 行政和沟通支持，建议和监督，以协调所有EaRTH中心的运作; 2） 一个综合健康科学设施核心（IHSFC），将提供研究设计、数据 整合、环境和社会压力因素数据以及研究成果的翻译和传播; 3)一个生物测定设施核心，将提供最先进的工具，用于测量化学品暴露及其 对生物途径的影响; 4）社区参与核心（CEC），以扩大环境健康 为学生和卫生专业人员提供教育和资源，将环境卫生纳入卫生保健; 和5）一个试点项目计划，以资助跨学科的项目，使研究人员进入该领域或增加一个 环境因素对当前研究的影响。我们的综合中心将导致新的科学 对环境健康的理解与我们的社区外展工作密切相关，这将改变 对环境在疾病中的作用有基本的了解，从而找到预防有害疾病的解决方案 暴露和改善健康。