Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs

在不同母婴群体中发现新型环境化学物质

基本信息

项目摘要

Project Summary/Abstract In utero exposure to multiple environmental chemicals has been shown to adversely impact health throughout the lifespan, leading to adverse birth outcomes, neurodevelopmental deficits, diabetes and obesity, and cancer. Yet, a key data gap limiting our ability to characterize and address developmental health risks is the lack of data on the extent to which neonates are exposed to the vast array of industrial chemicals used in the US. Over 90% of the chemicals manufactured and used in high volumes (>25,000 pounds/year) in the US are not measured in large-scale human biomonitoring studies. Further, the current biomonitoring approach requires a priori selection of compounds for which to develop and validate targeted analytical methods; the lack of data on chemical use in industrial or commercial products hinders the ability to accurately anticipate to which of the almost 8000 high use chemicals the US population is most likely exposed. To address these challenges, our project will advance an innovative, discovery-driven research project using liquid chromatography- quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) to perform a General Suspects Screen for the presence and co-occurrence of approximately 700 Environmental Organic Acids (EOAs) in a demographically diverse population of maternal-neonate pairs. We will also demonstrate how this screen can inform the selection of chemicals for targeted analysis methods development while addressing demographic disparities in EOA exposure and the extent to which maternal serum levels accurately reflect in utero exposures. We focus on EOAs because they are more easily detected by our LC-QTOF/MS and thus are a good model for our novel approach. Also, they are structurally similar to chemicals known to adversely impact development and thus are of potential health risk. Using LC-QTOF/MS, we will screen 300 matched umbilical cord and maternal serum samples, collected from a racially and economically diverse population, for ~ 700 EOAs. Using the LC- QTOF/MS results, we will identify 10 EOAs with potential for widespread human exposure and for demographic and maternal-neonatal exposure disparities. We will develop LC-MS/MS methods to confirm and quantify these 10 EOAs, and evaluate the performance of the LC-QTOF/MS screen. We will compare umbilical cord serum levels of the 10 EOAs in Hispanic versus non-Hispanic white, US– versus foreign-born, and low– versus high-income subgroups, and assess differences in exposures between maternal-fetal pairs. Our discovery-driven, suspect screen will pioneer a biomonitoring approach that prioritizes chemicals for targeted method development based on their likelihood of detection in the human population. It will also be an invaluable resource for other researchers who may query it for novel chemical exposures during the prenatal period. Finally, we will also make substantial contributions to the inventory of targeted methods for environmental chemicals and generate critical new exposure data on vulnerable and susceptible populations that is foundational to characterize and inform prevention of health risks from harmful chemicals.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Tracey J. Woodruff其他文献

Analyzing high-throughput assay data to advance the rapid screening of environmental chemicals for human reproductive toxicity
分析高通量检测数据以推进环境化学品对人类生殖毒性的快速筛查
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Julia R. Varshavsky;Juleen Lam;Courtney Cooper;Patrick Allard;J. Fung;Ashwini Oke;Ravinder Kumar;Joshua F. Robinson;Tracey J. Woodruff
  • 通讯作者:
    Tracey J. Woodruff
Authors’ rebuttal to Integrated Risk Information System (IRIS) response to “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools”
  • DOI:
    10.1186/s13643-022-01894-8
  • 发表时间:
    2022-03-23
  • 期刊:
  • 影响因子:
    3.900
  • 作者:
    Stephanie M. Eick;Dana E. Goin;Juleen Lam;Tracey J. Woodruff;Nicholas Chartres
  • 通讯作者:
    Nicholas Chartres
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
  • DOI:
    10.1016/j.envint.2024.109227
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    9.700
  • 作者:
    Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium
  • 通讯作者:
    for the ECHO Cohort Consortium
A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors—implications for research on perinatal outcomes in the ECHO program
对孕产妇产前暴露于环境化学物质和心理社会应激源的综述——对 ECHO 项目围产期结局研究的启示
  • DOI:
    10.1038/s41372-019-0510-y
  • 发表时间:
    2019-10-15
  • 期刊:
  • 影响因子:
    2.400
  • 作者:
    Amy M. Padula;Catherine Monk;Patricia A. Brennan;Ann Borders;Emily S. Barrett;Cindy T. McEvoy;Sophie Foss;Preeya Desai;Akram Alshawabkeh;Renee Wurth;Carolyn Salafia;Raina Fichorova;Julia Varshavsky;Amii Kress;Tracey J. Woodruff;Rachel Morello-Frosch
  • 通讯作者:
    Rachel Morello-Frosch
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
美国评估化学暴露与儿童健康的机会:儿童健康结果的环境影响(ECHO)计划
  • DOI:
    10.1038/s41370-020-0211-9
  • 发表时间:
    2020-02-17
  • 期刊:
  • 影响因子:
    4.700
  • 作者:
    Jessie P. Buckley;Emily S. Barrett;Paloma I. Beamer;Deborah H. Bennett;Michael S. Bloom;Timothy R. Fennell;Rebecca C. Fry;William E. Funk;Ghassan B. Hamra;Stephen S. Hecht;Kurunthachalam Kannan;Ramsunder Iyer;Margaret R. Karagas;Kristen Lyall;Patrick J. Parsons;Edo D. Pellizzari;Antonio J. Signes-Pastor;Anne P. Starling;Aolin Wang;Deborah J. Watkins;Mingyu Zhang;Tracey J. Woodruff
  • 通讯作者:
    Tracey J. Woodruff

Tracey J. Woodruff的其他文献

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{{ truncateString('Tracey J. Woodruff', 18)}}的其他基金

Administrative Core
行政核心
  • 批准号:
    10382449
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    10382448
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    9918111
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
加州大学旧金山分校健康中心环境研究与翻译(EaRTH 中心)
  • 批准号:
    10598480
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    9918112
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10598481
  • 财政年份:
    2020
  • 资助金额:
    $ 57.64万
  • 项目类别:
Revealing environmental chemical exposome in a diverse prenatal population and relationships to maternal and perinatal health (REVEAL)
揭示不同产前人群的环境化学暴露及其与孕产妇和围产期健康的关系 (REVEAL)
  • 批准号:
    10587408
  • 财政年份:
    2016
  • 资助金额:
    $ 57.64万
  • 项目类别:
Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs
在不同母婴群体中发现新型环境化学物质
  • 批准号:
    9768469
  • 财政年份:
    2016
  • 资助金额:
    $ 57.64万
  • 项目类别:
Discovery of novel environmental chemicals in a diverse population of maternal-infant pairs
在不同母婴群体中发现新型环境化学物质
  • 批准号:
    9157911
  • 财政年份:
    2016
  • 资助金额:
    $ 57.64万
  • 项目类别:
The UCSF Pregnancy Exposures to Environmental Chemicals (PEEC) Children's Center
加州大学旧金山分校怀孕期接触环境化学品 (PEEC) 儿童中心
  • 批准号:
    9079471
  • 财政年份:
    2013
  • 资助金额:
    $ 57.64万
  • 项目类别:

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