Biological Underpinnings of Maternal Attachment in High Risk Populations

高危人群母性依恋的生物学基础

• 批准号: 9213835
• 负责人: JEANNE L ALHUSEN
• 金额: $ 12.98万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-02 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9213835
• 关键词: Biological; Underpinnings; Maternal; Attachment; Risk

 DESCRIPTION (provided by applicant): This K23 application prepares the candidate, Jeanne Alhusen, PhD, for a research-intensive career leading multidisciplinary efforts to improve early childhood outcomes in children targeted by early intervention programs in community settings. Specifically, I aim to become an expert in the biological and psychological underpinnings of maternal attachment and its influence on maternal-child physiological attunement, and ultimately early childhood outcomes. Understanding these relations is critical in understanding, from a biological perspective, how secure maternal attachment may confer developmental advantages in young children living in poverty and how maternal biology can impact the effectiveness of early interventions. The overall aims of this proposal are to (a) examine the relations among maternal cortisol, oxytocin, attachment style, sensitivity, (b) examine the moderating role of maternal-child cortisol attunement on the association between maternal attachment style and maternal sensitivity and (c) examine the associations between maternal-child cortisol attunement and early childhood outcomes in 75 mother-child dyads living in urban poverty. In the short-term, the current proposal will allow me to gain the skills and expertise to conduct mentored research on the biological and psychological underpinnings of maternal attachment and their relation to maternal sensitivity, maternal-child physiological attunement, and ultimately early childhood outcomes. To accomplish this, I need to acquire a fundamentally different skill set. My training plan is explicitly designed to address gaps in my knowledge of maternal attachment and its related biological processes (i.e., cortisol, oxytocin) that may compromise early childhood outcomes. Short-term training objectives include training in 1) biological measures of attachment and stress, 2) parent-child interaction assessment, 3) advanced training in treatment outcome research and related statistical analyses and, 4) skills requisite for a successful academic career (i.e., responsible conduct of research, grantsmanship, leading interdisciplinary teams). These training goals, together with the specific aims of the research plan, will lead to an R01 application, the theme of which will be incorporating the biological underpinnings of attachment into developing interventions to improve maternal attachment which will ultimately improve caregiving quality and early childhood outcomes. Throughout the mentored award period, the candidate will work under the supervision of Dr. Gayle Page, Johns Hopkins University, and Dr. Linda Bullock, the University of Virginia, experts in biobehavioral and maternal mental health research, respectively. The candidate will also receive mentorship from three senior consultants (Dr. Lane Strathearn, Dr. Lisa Berlin, Dr. Sharon Ghazarian) with complementary areas of expertise, carefully selected to address each of her training goals.

 描述（由申请人提供）：此 K23 申请为候选人 Jeanne Alhusen 博士做好准备，让其从事研究密集型职业，领导多学科工作，以改善社区环境中早期干预计划所针对的儿童的早期儿童结局。具体来说，我的目标是成为母亲依恋的生物和心理基础及其对母婴生理协调以及最终儿童早期结局影响的专家。从生物学的角度来看，理解这些关系对于理解安全的母亲依恋如何为生活在贫困中的幼儿带来发展优势以及母亲的生物学如何影响早期干预的有效性至关重要。该提案的总体目标是（a）研究母亲皮质醇、催产素、依恋风格、敏感性之间的关系，（b）研究母子皮质醇协调对母亲依恋风格和母亲敏感性之间关系的调节作用，以及（c）研究生活在城市的 75 名母子二人组中母子皮质醇协调与早期儿童结局之间的关系 贫困。在短期内，当前的提案将使我获得技能和专业知识，以对母亲依恋的生物和心理基础及其与母亲敏感性、母子生理协调以及最终的早期儿童结局的关系进行指导性研究。为了实现这一目标，我需要获得一套完全不同的技能。我的培训计划明确旨在解决我对母性依恋及其相关生物过程（即皮质醇、催产素）的知识空白，这些知识可能会损害幼儿期的结果。短期培训目标包括以下方面的培训：1) 依恋和压力的生物学测量；2) 亲子互动评估；3) 治疗结果研究和相关统计分析方面的高级培训；4) 成功学术生涯所需的技能（即负责任的研究行为、资助、领导跨学科团队）。这些培训目标与研究计划的具体目标一起，将产生 R01 应用程序，其主题是将依恋的生物学基础纳入制定干预措施，以改善母亲依恋，最终提高护理质量和幼儿成果。在整个指导奖励期间，候选人将在约翰霍普金斯大学盖尔佩奇博士和弗吉尼亚大学琳达布洛克博士的监督下工作，他们分别是生物行为和孕产妇心理健康研究的专家。候选人还将获得三名高级顾问（Lane Strathearn 博士、Lisa Berlin 博士、Sharon Ghazarian 博士）的指导，这些顾问具有互补的专业领域，经过精心挑选，以实现她的每个培训目标。