Immunohematology/Transfusion Medicine Research Training

描述(由申请人提供)： 这项建议是为了续期我们于2001年发起的免疫血液学和输血医学博士后研究培训补助金。该计划提供了一个高度组织的2-3年专注的教学，研讨会，最重要的是，与24名成熟的，高度互动的，资金充足的跨学科导师之一，代表八个不同的主要部门的高度组织的研究经验。其目标是培养富有成效的医学博士和医学博士/博士内科科学家以及博士科学家和临床医生科学家，他们将开始终身研究生涯，在这个代表性不足的领域进行基础和转化性研究。由一个个性化的“职业与研究委员会”仔细地进行职业发展是该项目的一个标志。除了核心的博士后课程外，还提供三个学位授予“Track”：仅限MD的受训人员可获得调查医学博士学位，他们希望获得更广泛的研究背景，以模仿MD/PhD；耶鲁CTSA为有临床/转化性研究目标的人提供健康科学硕士学位；以及生物医学工程硕士学位，面向过去强调基础生物医学的受训人员，他们希望在他们的知识库中增加工程方面的内容。从一个专注于实验室医学和病理学背景的考生池中挑选出来的结果是相当积极的。在T32项目的毕业生中，25%的人成功完成了学位授予，50%的人获得了终身教职，其余的人留在了职业发展的早期阶段进行研究；所有人都获得了一些后续资金，25%直接获得了K08奖项。T32计划目前每年支持四个博士后职位，根据结果和候选人库，我们要求增加到六个职位。“核心”T32是“杠杆”的，因为整个实验室医学部免疫血液学-输血医学培训计划比T32更大-它包括其他资助机制的个人。如果将他们包括在内，69%的毕业生拥有调查性终身教职跟踪职位，38%的毕业生获得了PI-Level R01的资助。我们相信，这个项目满足了耶鲁大学和全国的一个重要的研究培训需求。

DESCRIPTION (provided by applicant): This proposal is for renewal of our postdoctoral research training grant in Immunohematology and Transfusion Medicine that was initiated in 2001. The program provides a highly organized 2-3 year program of focused dedicated didactics, seminars, and, most importantly, an intense research experience with one of 24 well-established, highly interactive, and well-funded cross-disciplinary mentors representing eight different primary departments. The goal is to generate productive MD and MD/PhD physician- scientists as well as PhD scientists and clinician-scientists, who will be launched on a lifelong investigative career pursuing basic and translational research in this underrepresented field. Careful career development by an individualized "Career & Research Committee" is a hallmark of the program. Three degree-granting "tracks" are also available, in addition to the core post-doctoral program: an Investigative Medicine PhD available to MD-only trainees who wish to obtain a more expansive research background mimicking that of an MD/PhD; a Masters of Health Sciences under the aegis of the Yale CTSA for those with a clinical/translational research goal; and a Masters of Biomedical Engineering for trainees with a past basic biomedicine emphasis who wish to add an engineering dimension to their knowledge base. Drawn from a candidate pool focused on those whose background is Laboratory Medicine & Pathology (a pool which has always included at least 10 fold more excellent candidates than are accepted into the program), outcomes have been quite positive. Of the graduates of the T32 program, 25% have successfully completed a degree-granting track, 50% have secured tenure track academic investigative positions, with the remainder retained in research at earlier career development stages; all have obtained some subsequent funding with 25% moving directly to K08 awards. The T32 program currently supports four post-doctoral positions per year and, based on results and candidate pool, we are requesting an increase to six positions. The "core" T32 is "leveraged", since the entire Laboratory Medicine Departmental Immunohematology-Transfusion Medicine training program is greater than the T32 - it includes individuals on other funding mechanisms. When they are included, 69% of graduates have investigative tenure track positions and 38% have attained PI-level R01 funding. We believe that this program fills an important research training need both at Yale and nationally.