Research training in HIV-related transfusion medicine and hematology in South Africa

南非艾滋病毒相关输血医学和血液学研究培训

• 批准号: 9977297
• 负责人: EDWARD L MURPHY
• 金额: $ 30.24万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9977297
• 关键词: AIDS-Related Lymphoma; Address; African; Anemia; Biological; Biological Assay; Biometry; Blood; California; Clinical Research; Collaborations; Country; Data Analyses; Databases; Development; Discipline; Doctor of Philosophy; Epidemic; Faculty; Funding; Grant; HIV; HIV Infections; HIV therapy; Health Sciences; Health Services Research; Hematologist; Hematology; Incidence; Institutes; International; Internships; Manuscripts; Measures; Medical; Mentors; National Heart, Lung, and Blood Institute; Needs Assessment; Patients; Preparation; Prevalence; Protocols documentation; Recording of previous events; Research; Research Design; Research Infrastructure; Research Institute; Research Methodology; Research Project Grants; Research Training; Risk Factors; San Francisco; Schools; Scientist; Series; Services; South Africa; South African; Specimen; Training; Training Programs; Transfusion; Universities; Vascular blood supply; Vision; Work; career; design; human capital; human subject; novel; programs; research and development; service organization; skills; systems research; transfusion medicine; trend

PROJECT SUMMARY/ABSTRACT The proposed University of California San Francisco (UCSF)/Blood Systems Research Institute (BSRI), University of Cape Town (UCT) and South Africa National Blood Service (SANBS) research training program in HIV-related transfusion medicine and hematology research will train blood bankers and hematologists to perform high-quality HIV research to address relevant research questions in South Africa. South Africa needs research on its HIV epidemic's impact on the national blood supply and HIV-related hematology complications. Since 2007, we have already accomplished a series of in-country short courses and identified a pool of 30-50 potential junior scientists for in-country HIV research in transfusion medicine and hematology among SANBS staff and UCT junior faculty and medical postgraduates but their potential remains unfulfilled. This proposal builds upon a 15-year history of HIV research collaboration between SANBS and UCSF/BSRI that yielded research evidence to support a safe and adequate blood supply in South Africa. Under the NHLBI-funded REDS-III International HIV research network, this collaboration will provide a funded research infrastructure for trainees through 2019. Our needs assessment indicates that specific deficiencies in biostatistics, manuscript preparation and research career mentoring need to be overcome to achieve our vision of a sustainable, independent HIV-related transfusion medicine and hematology research enterprise in South Africa. We propose Specific Aims of: 1) a research and development institute at SANBS; 2) an academic UCT Hematology Division; and 3) broader human capital development to raise South Africa as a regional center of excellence in this research. A three-tiered educational approach will be tailored to trainees at various levels of their research careers: in-country short courses on clinical research methodology and protocol design will reach a large number of trainees; for a smaller number lacking skills in study design, biostatistics and data analysis we propose medium-term internships in Cape Town and San Francisco including course work and research internships; finally, for a select few, Master's and PhD training in specific research disciplines will be tailored to their needs at the UCT School of Health Sciences. Throughout, trainees will be mentored as they accomplish their own research projects and compete for mini-grants funded by the program. The REDS-III HIV research network will provide research opportunities in terms of access to human subjects, databases and biological specimens. Research projects will address high-priority questions in HIV-related transfusion medicine and hematology in South Africa, including: HIV prevalence and incidence as measured by novel assays; risk factors for incident HIV infection to detect new trends in the epidemic; HIV-related anemia; appropriate transfusion therapy for HIV patients; and HIV lymphomas. The result of this program will be a substantial improvement in human capital for HIV-related transfusion medicine and hematology research within the two South African blood service organizations, UCT and neighboring southern African countries.

项目总结/摘要 加州大学弗朗西斯科分校（UCSF）/血液系统研究所（BSRI）， 开普敦大学（UCT）和南非国家血液服务中心（SANBS）的研究培训计划， 与艾滋病毒有关的输血医学和血液学研究将培训血库和血液学家， 开展高质量的艾滋病毒研究，以解决南非的相关研究问题。南非需要 研究艾滋病毒流行对全国血液供应的影响以及艾滋病毒相关血液学并发症。 自2007年以来，我们已经完成了一系列国内短期课程，并确定了30-50人的人才库 南非国家生物安全局输血医学和血液学方面国内艾滋病毒研究的潜在初级科学家 工作人员和UCT初级教师和医学研究生，但他们的潜力仍然没有实现。这项建议 建立在15年的历史上艾滋病毒研究合作之间的SANBS和UCSF/BSRI，产生了 研究证据支持南非安全和充足的血液供应。根据NHLBI资助的 REDS-III国际艾滋病毒研究网络，这项合作将提供资助的研究基础设施， 2019年的实习生。我们的需求评估表明，在生物统计学，手稿， 准备和研究职业指导需要克服，以实现我们的愿景， 南非独立的艾滋病毒相关输血医学和血液学研究企业。我们 提出具体目标：1）在南非国家统计局的研究和发展机构; 2）学术UCT 血液科; 3）更广泛的人力资本发展，以提高南非作为一个区域中心， 在这项研究中的卓越。我们会为不同程度的学员提供三层教育模式， 他们的研究生涯：关于临床研究方法和方案设计的国内短期课程将 接触到大量的受训人员;少数人缺乏研究设计、生物统计和数据方面的技能 分析，我们建议在开普敦和旧金山弗朗西斯科的中期实习，包括课程工作， 研究实习;最后，对于少数人来说，特定研究学科的硕士和博士培训将是 根据他们的需求在健康科学的UCT学校。在整个过程中，学员将得到指导，因为他们 完成自己的研究项目，并争取由该计划资助的小额赠款。REDS-III HIV 研究网络将在获取人类受试者、数据库和 生物标本研究项目将解决与艾滋病毒有关的输血中的高度优先问题 南非的医学和血液学，包括：艾滋病毒流行率和发病率， 艾滋病毒检测;艾滋病毒感染事件的风险因素，以发现流行病的新趋势;艾滋病毒相关贫血; 为艾滋病患者提供适当的输血治疗;以及艾滋病淋巴瘤。该计划的结果将是一个 大幅度改善国内艾滋病毒相关输血医学和血液学研究的人力资本 两个南非血液服务组织，UCT和邻近的南部非洲国家。