Research training in HIV-related transfusion medicine and hematology in South Africa

项目摘要/摘要 拟议的加州大学旧金山分校(UCSF)/血液系统研究所(BSRI)， 年，开普敦大学(UCT)和南非国家血液服务中心(SANBS)的研究培训计划 艾滋病毒相关输血医学和血液学研究将培训血液银行家和血液学家 进行高质量的艾滋病毒研究，以解决南非的相关研究问题。南非需要 HIV流行对全国血液供应的影响及HIV相关血液病并发症的研究。 自2007年以来，我们已经完成了一系列的国内短期课程，并确定了30-50人的池 国家发改委在输血医学和血液学领域潜在的初级科学家 工作人员和UCT初级教员和医学研究生，但他们的潜力仍然没有得到充分发挥。这项建议 建立在SANBS和UCSF/BSRI之间长达15年的艾滋病毒研究合作历史的基础上， 支持南非安全和充足的血液供应的研究证据。根据NHLBI资助的 REDS-III国际艾滋病毒研究网络，这一合作将为以下项目提供资助的研究基础设施 学员将持续到2019年。我们的需求评估表明，生物统计学方面的具体不足，手稿 准备和研究职业指导需要克服，以实现我们的愿景，可持续， 南非独立的艾滋病毒相关输血医学和血液学研究企业。我们 提出具体目标：1)在国家统计局建立一个研发机构；2)建立一个学术大学 血液科；以及3)更广泛的人力资本开发，将南非提升为区域中心 在这项研究中表现出色。将为不同级别的学员量身定做三级教育方法 他们的研究生涯：关于临床研究方法学和方案设计的国内短期课程将 接触到大量受训人员；为数不多的缺乏研究设计、生物统计和数据技能的人 分析我们建议在开普敦和旧金山进行中期实习，包括课程工作和 研究实习；最后，对于选定的少数人，特定研究学科的硕士和博士培训将是 在UCT健康科学学院根据他们的需求量身定做。从始至终，受训者都将得到指导，因为他们 完成他们自己的研究项目，并竞争该计划资助的微型补助金。红军--HIV-III 研究网络将在获取人类受试者、数据库和数据方面提供研究机会 生物标本。研究项目将解决艾滋病毒相关输血中的高优先级问题 南非的医学和血液学，包括：由Noval衡量的艾滋病毒流行率和发病率 检测；艾滋病毒感染事件的风险因素，以发现疫情的新趋势；艾滋病毒相关贫血； 为艾滋病毒患者和艾滋病毒淋巴瘤患者提供适当的输血治疗。这个计划的结果将是一个 年内艾滋病毒相关输血医学和血液学研究的人力资本大幅改善 这两个南非血液服务组织，UCT和邻近的南部非洲国家。

PROJECT SUMMARY/ABSTRACT The proposed University of California San Francisco (UCSF)/Blood Systems Research Institute (BSRI), University of Cape Town (UCT) and South Africa National Blood Service (SANBS) research training program in HIV-related transfusion medicine and hematology research will train blood bankers and hematologists to perform high-quality HIV research to address relevant research questions in South Africa. South Africa needs research on its HIV epidemic's impact on the national blood supply and HIV-related hematology complications. Since 2007, we have already accomplished a series of in-country short courses and identified a pool of 30-50 potential junior scientists for in-country HIV research in transfusion medicine and hematology among SANBS staff and UCT junior faculty and medical postgraduates but their potential remains unfulfilled. This proposal builds upon a 15-year history of HIV research collaboration between SANBS and UCSF/BSRI that yielded research evidence to support a safe and adequate blood supply in South Africa. Under the NHLBI-funded REDS-III International HIV research network, this collaboration will provide a funded research infrastructure for trainees through 2019. Our needs assessment indicates that specific deficiencies in biostatistics, manuscript preparation and research career mentoring need to be overcome to achieve our vision of a sustainable, independent HIV-related transfusion medicine and hematology research enterprise in South Africa. We propose Specific Aims of: 1) a research and development institute at SANBS; 2) an academic UCT Hematology Division; and 3) broader human capital development to raise South Africa as a regional center of excellence in this research. A three-tiered educational approach will be tailored to trainees at various levels of their research careers: in-country short courses on clinical research methodology and protocol design will reach a large number of trainees; for a smaller number lacking skills in study design, biostatistics and data analysis we propose medium-term internships in Cape Town and San Francisco including course work and research internships; finally, for a select few, Master's and PhD training in specific research disciplines will be tailored to their needs at the UCT School of Health Sciences. Throughout, trainees will be mentored as they accomplish their own research projects and compete for mini-grants funded by the program. The REDS-III HIV research network will provide research opportunities in terms of access to human subjects, databases and biological specimens. Research projects will address high-priority questions in HIV-related transfusion medicine and hematology in South Africa, including: HIV prevalence and incidence as measured by novel assays; risk factors for incident HIV infection to detect new trends in the epidemic; HIV-related anemia; appropriate transfusion therapy for HIV patients; and HIV lymphomas. The result of this program will be a substantial improvement in human capital for HIV-related transfusion medicine and hematology research within the two South African blood service organizations, UCT and neighboring southern African countries.