Research training in HIV-related transfusion medicine and hematology in South Africa
Research training in HIV-related transfusion medicine and hematology in South Africa
批准号:
10248622
负责人:
EDWARD L MURPHY
金额:
$7.3万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-08-15 至 2022-07-31
关键词:
AIDS-Related LymphomaAddressAfricanAnemiaBiologicalBiological AssayBiometryBloodCaliforniaClinical ResearchCollaborationsCountryData AnalysesDatabasesDevelopmentDisciplineDoctor of PhilosophyEpidemicFacultyFundingGrantHIVHIV InfectionsHIV therapyHealth SciencesHealth Services ResearchHematologistHematologyIncidenceInstitutesInternationalInternshipsManuscriptsMeasuresMedicalMentorsNational Heart, Lung, and Blood InstituteNeeds AssessmentPatientsPreparationPrevalenceProtocols documentationRecording of previous eventsResearchResearch DesignResearch InfrastructureResearch InstituteResearch MethodologyResearch Project GrantsResearch TrainingRisk FactorsSan FranciscoSchoolsScientistSeriesServicesSouth AfricaSouth AfricanSpecimenTrainingTraining ProgramsTransfusionUniversitiesVascular blood supplyVisionWorkcareerdesignhuman capitalhuman subjectnovelprogramsresearch and developmentservice organizationskillssystems researchtransfusion medicinetrend
中文摘要
项目概要/摘要
拟议的加州大学旧金山分校 (UCSF)/血液系统研究所 (BSRI),
开普敦大学 (UCT) 和南非国家血液服务中心 (SANBS) 研究培训项目
与艾滋病毒相关的输血医学和血液学研究将培训血库人员和血液学家
进行高质量的艾滋病毒研究,以解决南非的相关研究问题。南非需要
研究艾滋病流行对全国血液供应的影响以及艾滋病相关的血液学并发症。
自2007年以来,我们已经完成了一系列国内短期课程,并确定了30-50名学员
SANBS 中输血医学和血液学国内艾滋病毒研究的潜在青年科学家
工作人员和 UCT 初级教师和医学研究生,但他们的潜力仍未得到发挥。这个提议
SANBS 和 UCSF/BSRI 之间 15 年的艾滋病毒研究合作历史为基础,该合作取得了成果
研究证据支持南非的安全和充足的血液供应。在 NHLBI 资助下
REDS-III 国际艾滋病毒研究网络,此次合作将为以下项目提供资助的研究基础设施:
2019 年受训人员。我们的需求评估表明,生物统计学、手稿方面的具体缺陷
为了实现我们可持续发展的愿景,需要克服准备和研究职业指导的问题。
南非独立的艾滋病毒相关输血医学和血液学研究企业。我们
提出以下具体目标: 1) SANBS 的研发机构; 2) 学术UCT
血液科; 3) 更广泛的人力资本开发,将南非提升为区域中心
在这项研究中表现出色。将为不同层次的学员量身定制三级教育方法
他们的研究生涯:关于临床研究方法和方案设计的国内短期课程将
接触到大量的学员;对于少数缺乏研究设计、生物统计学和数据技能的人
根据分析,我们建议在开普敦和旧金山进行中期实习,包括课程作业和
研究实习;最后,对于少数人来说,特定研究学科的硕士和博士培训将是
UCT 健康科学学院根据他们的需求量身定制。在整个过程中,学员将受到指导
完成自己的研究项目并竞争该计划资助的小额赠款。 REDS-III HIV
研究网络将在获取人类受试者、数据库和
生物标本。研究项目将解决与艾滋病毒相关的输血中的高度优先问题
南非的医学和血液学,包括: 通过新方法衡量的艾滋病毒流行率和发病率
化验;艾滋病毒感染事件的危险因素,以发现流行病的新趋势;艾滋病毒相关贫血;
对艾滋病毒患者进行适当的输血治疗;和艾滋病毒淋巴瘤。该程序的结果将是
艾滋病毒相关输血医学和血液学研究的人力资本大幅改善
两个南非血液服务组织 UCT 和邻近的南部非洲国家。
英文摘要
PROJECT SUMMARY/ABSTRACT
The proposed University of California San Francisco (UCSF)/Blood Systems Research Institute (BSRI),
University of Cape Town (UCT) and South Africa National Blood Service (SANBS) research training program in
HIV-related transfusion medicine and hematology research will train blood bankers and hematologists to
perform high-quality HIV research to address relevant research questions in South Africa. South Africa needs
research on its HIV epidemic's impact on the national blood supply and HIV-related hematology complications.
Since 2007, we have already accomplished a series of in-country short courses and identified a pool of 30-50
potential junior scientists for in-country HIV research in transfusion medicine and hematology among SANBS
staff and UCT junior faculty and medical postgraduates but their potential remains unfulfilled. This proposal
builds upon a 15-year history of HIV research collaboration between SANBS and UCSF/BSRI that yielded
research evidence to support a safe and adequate blood supply in South Africa. Under the NHLBI-funded
REDS-III International HIV research network, this collaboration will provide a funded research infrastructure for
trainees through 2019. Our needs assessment indicates that specific deficiencies in biostatistics, manuscript
preparation and research career mentoring need to be overcome to achieve our vision of a sustainable,
independent HIV-related transfusion medicine and hematology research enterprise in South Africa. We
propose Specific Aims of: 1) a research and development institute at SANBS; 2) an academic UCT
Hematology Division; and 3) broader human capital development to raise South Africa as a regional center of
excellence in this research. A three-tiered educational approach will be tailored to trainees at various levels of
their research careers: in-country short courses on clinical research methodology and protocol design will
reach a large number of trainees; for a smaller number lacking skills in study design, biostatistics and data
analysis we propose medium-term internships in Cape Town and San Francisco including course work and
research internships; finally, for a select few, Master's and PhD training in specific research disciplines will be
tailored to their needs at the UCT School of Health Sciences. Throughout, trainees will be mentored as they
accomplish their own research projects and compete for mini-grants funded by the program. The REDS-III HIV
research network will provide research opportunities in terms of access to human subjects, databases and
biological specimens. Research projects will address high-priority questions in HIV-related transfusion
medicine and hematology in South Africa, including: HIV prevalence and incidence as measured by novel
assays; risk factors for incident HIV infection to detect new trends in the epidemic; HIV-related anemia;
appropriate transfusion therapy for HIV patients; and HIV lymphomas. The result of this program will be a
substantial improvement in human capital for HIV-related transfusion medicine and hematology research within
the two South African blood service organizations, UCT and neighboring southern African countries.
期刊论文(0)
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会议论文
Research training in HIV-related transfusion medicine and hematology in South Africa
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批准号:9977297
-
项目类别:
-
资助金额:$30.24万
-
财政年份:2017
-
负责人:EDWARD L MURPHY
-
依托单位:
Blood Research and EnhAnced Training against HIV in South Africa (BREATH-SA)
-
批准号:10875043
-
项目类别:
-
资助金额:$15.0万
-
财政年份:2017
-
负责人:EDWARD L MURPHY
-
依托单位:
XV International Conference on Human Retrovirology: HTLV and Related Viruses
-
批准号:8126612
-
项目类别:
-
资助金额:$0.2万
-
财政年份:2011
-
负责人:EDWARD L MURPHY
-
依托单位:
Clinical Epidemiology of HTLV-I and HTLV-II Infection
-
批准号:6704954
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Health Outcomes in Blood Donors and Recipients
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批准号:8073046
-
项目类别:
-
资助金额:$17.86万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Health Outcomes in Blood Donors and Recipients
-
批准号:7739298
-
项目类别:
-
资助金额:$17.67万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Health Outcomes in Blood Donors and Recipients
-
批准号:8474822
-
项目类别:
-
资助金额:$17.86万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Health Outcomes in Blood Donors and Recipients
-
批准号:8270509
-
项目类别:
-
资助金额:$17.86万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Clinical Epidemiology of HTLV-I and HTLV-II Infection
-
批准号:7166834
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Clinical Epidemiology of HTLV-I and HTLV-II Infection
-
批准号:6991203
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Clinical Epidemiology of HTLV-I and HTLV-II Infection
-
批准号:6841613
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
Clinical Epidemiology of HTLV-I and HTLV-II Infection
-
批准号:7383104
-
项目类别:
-
资助金额:$13.23万
-
财政年份:2004
-
负责人:EDWARD L MURPHY
-
依托单位:
XI International Conference on Human Retrovirology: HTLV
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批准号:7064840
-
项目类别:
-
资助金额:$1.3万
-
财政年份:2003
-
负责人:EDWARD L MURPHY
-
依托单位:
XI International Conference on Human Retrovirology: HTLV
-
批准号:6949953
-
项目类别:
-
资助金额:$1.0万
-
财政年份:2003
-
负责人:EDWARD L MURPHY
-
依托单位:
XI International Conference on Human Retrovirology: HTLV
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批准号:6559867
-
项目类别:
-
资助金额:$4.6万
-
财政年份:2003
-
负责人:EDWARD L MURPHY
-
依托单位:
PATHOPHYSIOLOGY OF HTLV1 AND HTLVII INFECTION
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批准号:6184619
-
项目类别:
-
资助金额:$118.01万
-
财政年份:1999
-
负责人:EDWARD L MURPHY
-
依托单位:
PATHOPHYSIOLOGY OF HTLV1 AND HTLVII INFECTION
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批准号:2824181
-
项目类别:
-
资助金额:$120.74万
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财政年份:1999
-
负责人:EDWARD L MURPHY
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依托单位:
Pathophysiology of HTLV-I and HTLV-II Infection
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批准号:7341634
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项目类别:
-
资助金额:$92.87万
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财政年份:1999
-
负责人:EDWARD L MURPHY
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依托单位:
PATHOPHYSIOLOGY OF HTLV1 AND HTLVII INFECTION
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批准号:6616974
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项目类别:
-
资助金额:$7.5万
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财政年份:1999
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负责人:EDWARD L MURPHY
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依托单位:
Pathophysiology of HTLV-I and HTLV-II Infection
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批准号:7015068
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项目类别:
-
资助金额:$92.6万
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财政年份:1999
-
负责人:EDWARD L MURPHY
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依托单位:
海外基金