The role of sweet taste genes in postingestive endocrine responses to sweeteners

甜味基因在食后内分泌对甜味剂的反应中的作用

• 批准号: 8843412
• 负责人: ALEXANDER A BACHMANOV
• 金额: $ 6.51万
• 依托单位: MONELL CHEMICAL SENSES CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-10 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8843412
• 关键词: Academy; Acids; Affect; Alleles; Amino Acids; Behavior; Behavioral; Beverages; Blood; Brain; Breeding; Candidate Disease Gene; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 9; Collaborations; Complement; Congenic Mice; Congenic Strain; Consumption; Digestion; Disease; Endocrine; Ethanol; Feeding behaviors; Flavoring; Food; GNAI2 gene; Genes; Genetic; Genome; Glucose; Glycine; Goals; Grant; Health; Hormones; Human; Hypertension; Inbred Mouse; Inbred Strain; Inbred Strains Mice; Inbreeding; Individual; Institutes; Insulin; Intake; Knock-out; Link; Maps; Metabolic syndrome; Metabolism; Molecular; Monitor; Mouse Strains; Mus; Nutrient; Obesity; Organ; Orthologous Gene; Phenotype; Physiological; Physiology; Principal Investigator; Process; Proteins; Quantitative Trait Loci; Receptor Gene; Research; Resolution; Rewards; Role; Russia; Saccharin; Science; Scientist; Site; Staging; Sucrose; Surveys; Sweetening Agents; Taste Bud Cell; Taste Buds; Taste Perception; Techniques; Testing; Tissues; United States; United States National Institutes of Health; Variant; base; behavioral response; consomic; detection of nutrient; economic impact; follow-up; food consumption; gene cloning; genetic linkage analysis; genetic variant; glucagon-like peptide 1; hormone metabolism; improved; mouse model; novel; null mutation; parent grant; parent project; positional cloning; preference; programs; receptor; research study; response; sensory system; sugar; sweet taste perception; taste stimuli; therapy design

DESCRIPTION (provided by applicant): Taste is the primary sensory system that determines whether a food or beverage will be ingested or rejected. Taste also influences the digestion and metabolism of food. Consequently, understanding the mechanisms underlying this sense is central to our ability to control intake of nutrients and modulate the excesses of consumption that contribute to diseases such as obesity, hypertension and the metabolic syndrome. These diseases pose serious problems for human health and have major negative economic impact worldwide, including in the United States and Russia. The long-term goal of the parent project is to positionally clone genes involved in taste and ingestive behavior. This involves developing genetically defined mouse models for genetic mapping and mechanistic studies. This FIRCA proposal will expand these studies to examine the role of sweet taste genes in postingestive endocrine responses to sweeteners. The proposed studies will aid in gene identification in mice, which will reveal the function of their human orthologs and their role in taste-related human behavior. This project will support collaboration between scientists at the Monell Center and the Pavlov Institute and will help to build research capabilities at the Pavlov Institute. The propose research will be done primarily in Russia at the Pavlov Institute of Physiology of the Russian Academy of Sciences in collaboration with Dr. Zolotarev as an extension of NIH grant R01DC000882 (09/19/2008 - 08/31/2013). PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

描述（由申请人提供）：味觉是决定食物或饮料是否被摄入或拒绝的主要感觉系统。味道也影响食物的消化和新陈代谢。因此，了解这种感觉背后的机制对于我们控制营养素摄入和调节导致肥胖、高血压和代谢综合征等疾病的过度消费的能力至关重要。这些疾病对人类健康构成严重问题，并在全世界，包括美国和俄罗斯，产生重大的负面经济影响。 该项目的长期目标是定位克隆与味觉和摄食行为有关的基因。这涉及开发用于遗传作图和机理研究的遗传定义的小鼠模型。FIRCA的建议将扩大这些研究，以研究甜味基因在甜味剂的消化后内分泌反应中的作用。这些研究将有助于小鼠的基因鉴定，这将揭示它们的人类直系同源物的功能及其在与味觉相关的人类行为中的作用。该项目将支持莫内尔中心和巴甫洛夫研究所的科学家之间的合作，并将有助于建立巴甫洛夫研究所的研究能力。 该研究将主要在俄罗斯科学院巴甫洛夫生理学研究所与Zolotarev博士合作进行，作为NIH资助R 01 DC 000882（09/19/2008 - 08/31/2013）的扩展。PHS 398/2590（2004年9月修订，2006年4月重新印发）