MCHEAR: Michigan Exposure Assessment Laboratory Hub

MCHEAR：密歇根暴露评估实验室中心

• 批准号: 9062026
• 负责人: John D. Meeker
• 金额: $ 48.92万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9062026
• 关键词: Address; Analytical Chemistry; Bioinformatics; Biological; Biological Markers; Biometry; Budgets; Child; Child health care; Clinical Research; Collaborations; Communication; Communities; Computer software; Consult; Consultations; Custom; Data; Development; Electronic Mail; Ensure; Environment; Environmental Epidemiology; Grant; Growth and Development function; Human; Human Resources; Intake; International; Knowledge; Laboratories; Leadership; Link; Management Information Systems; Michigan; Molecular Epidemiology; National Institute of Environmental Health Sciences; Process; Progress Reports; Research; Research Design; Research Personnel; Research Support; Resources; Robin bird; Sampling; Science; Self Assessment; Services; Telephone; Time; United States National Institutes of Health; Universities; Validation; cost; data management; design; epidemiology study; epigenomics; experience; flexibility; innovation; laboratory facility; meetings; metabolomics; nutrition; operation; organizational structure; response; sample collection; symposium; web site

ABSTRACT (Administrative Core) The primary objective of the Michigan Children’s Health Exposure Analysis Resource (M-CHEAR) Laboratory Hub is to contribute to large-scale national efforts to advance our knowledge of the impact of the environment on children’s health by offering high-quality, state-of-the-art laboratory support for a wide assortment of targeted and untargeted analyses in biological samples from external researchers conducting epidemiology and clinical studies of child health. The M-CHEAR Administrative Core is designed to ensure effective and efficient use of Hub resources to best serve the needs of the external researchers. This will be achieved through an informative website interface and the coordination of expert consultation on study design and sample analysis needs, regular external and internal communications and meetings, use of state-of-the art laboratory management software, a flexible organizational structure and budget, and regular internal assessments aimed at continuous quality improvement. Specific Aims and Tasks of the Administrative Core include the following: 1) Provide overall administrative and organizational oversight and management of the Hub to ensure time- and cost-efficient sample analysis for external children’s health researchers; 2) Promote Hub services to external users by building and maintaining an informational Hub website that can be linked through NIEHS, CHEAR Coordinating Center, and other relevant portals; 3) Advise and coordinate expert consultation with external applicants on issues of study design, sample collection and processing, multiple analysis possibilities, data management/analysis, and other topics; 4) Harmonize efforts with the CHEAR Coordinating Center, CHEAR Data Center, CHEAR Steering Committee and Scientific Consulting Panel, NIH Staff, and other stakeholders through attendance at bi-annual meetings, monthly conference calls, and use of informal communications (email, phone calls); 5) Communicate with other CHEAR Lab Hubs to capitalize on one another’s capabilities and expertise; 6) Oversee participation of M-CHEAR Resource and Core laboratories in round-robin assessments; 7) Serve as the point of contact for sample intake, storage, tracking and management for the Hub, and coordinate sample transfer to the appropriate Analytical Resource or Core. This will be facilitated through the use of a custom, state-of-the-art laboratory information management system (LIMS); 8) Facilitate effective communication between Hub Cores and Analytical Resources through organization of regular (bi-weekly) meetings of Core/Resource leaders and key personnel; 9) Provide flexible organizational structures and budgets to allow for agile response to address evolving CHEAR needs and priorities, and to promote Hub excellence in quality, collaboration, and innovation; 10) Conduct regular internal self-assessments to inform efforts toward continuous quality improvement in Hub operations, services offered, and ability to anticipate researcher needs; and 11) Generate comprehensive Hub progress reports to NIH.

摘要（行政核心） 密歇根儿童健康暴露分析资源实验室（Michigan Children's Health Exposure Analysis Resource Laboratory，M-CHEARS） 该中心旨在为大规模的国家努力做出贡献，以提高我们对环境影响的认识 通过为各种各样的儿童提供高质量、最先进的实验室支持， 对来自外部流行病学研究人员的生物样本进行靶向和非靶向分析 和儿童健康的临床研究。M-CHESTIC行政核心旨在确保有效和 有效利用中心资源，以最好地满足外部研究人员的需求。完成这项工作的方法是 通过信息丰富的网站界面和协调研究设计方面的专家咨询， 样品分析需求，定期的外部和内部沟通和会议，使用最先进的 实验室管理软件，灵活的组织结构和预算，以及定期的内部 以持续质量改进为目标的评估。行政核心的具体目标和任务 包括以下内容：（1）提供全面的行政和组织监督和管理 中心，确保外部儿童健康研究人员进行具有时间和成本效益的样本分析; 2）促进 通过建立和维护可链接的信息中心网站，为外部用户提供中心服务 通过NIEHS、CHEMICAL协调中心和其他相关门户网站; 3）建议和协调专家 与外部申请人就研究设计、样本采集和处理、多个 分析可能性、数据管理/分析和其他主题; 4）与CHEMICAL协调工作 协调中心，CHESTIC数据中心，CHESTIC指导委员会和科学咨询小组，NIH 工作人员和其他利益攸关方通过出席半年一次的会议、每月电话会议和使用 非正式沟通（电子邮件，电话）; 5）与其他CHEMICAL Lab Hub沟通， 彼此的能力和专业知识; 6）监督M-CHESTIC资源和核心的参与 7）作为样本采集、储存、跟踪和分析的联络点; 中心的管理，并协调样品转移到适当的分析资源或核心。 这将通过使用定制的、最先进的实验室信息管理系统来促进 （LIMS）; 8）通过以下方式促进中心核心和分析资源之间的有效沟通 组织核心/资源领导人和关键人员的定期（双周）会议; 9）提供灵活的 组织结构和预算，以便灵活应对不断变化的CHEMICAL需求， 优先事项，并促进枢纽在质量，协作和创新方面的卓越表现; 10）定期进行内部 自我评估，为中心运营、提供的服务、 和预测研究人员需求的能力;和11）生成全面的枢纽进展报告给NIH。