Data & Information Tech Core - Athey

项目概述（见说明）：密歇根区域综合代谢组学资源核心（MRC2）的数据和信息技术核心将为定向代谢组学数据的光谱数据分析提供专业知识，并为使用更广泛的代谢组学分析的高通量、非靶向代谢物分析提供重要工具和研究。通过反相和亲水性相互作用色谱（HILIC）、飞行时间（TOF）测定了近748种真实代谢物的光谱特征，以及在近500个血浆样品中鉴定出的已知未知物文库的可用性，将增强非靶向代谢组学剖面中化合物的鉴定。Core还将提供数据分析之前的数据规范化程序。Core还将负责数据管理、注释和存储，并将与数据存储库和协调中心（DRCC）合作，提供在Core中进行的原始和规范化的实验。数据和信息技术核心将与密歇根大学的IT团队合作，维护、排除故障并升级MRC2的信息技术基础设施。

PROJECT SUMMARY (See Instructions): The Data and Information Technology Core of the Michigan Regional Comprehensive Metabolomics Resource Core (MRC2) will provide expertise for the analysis of spectral data from directed metabolomics data and provide important tools and research in the analysis of high-throughput, untargeted metabolite analysis used wider profiling of the metabolome. The identification of compounds in the untargeted metabolomics profile will be enhanced by the availability of a library of nearly 748 authentic metabolites whose spectral features have been determined on reverse phase and hydrophilic interaction chromatography (HILIC) time of flight (TOF) as well as a library of known unknowns' identified in nearly 500 plasma samples. The Core will also provide procedures for data normalization prior to data analysis. The Core also will be responsible for data curation, annotation and storage and will work with the Data Repository and Coordinating Center (DRCC) to provide raw and normalized of experiments performed in the core. The Data and Information Technology Core will work with IT teams within the University of Michigan to maintain, troubleshoot and upgrade the Information Technology infrastructure of the MRC2.