Early Identification of Affected Children and Risk Factors for FASD in Ukraine

描述(由申请人提供)：据估计，胎儿酒精谱系障碍(FASD)是世界各地儿童中最常见的神经发育障碍。促进我们对可能改变FASD风险的因素的理解，仍然是可能推动世界各地预防和干预战略的研究的关键差距。乌克兰在本供资期间建立了纵向队列样本，详细记录了产前酒精暴露、产妇营养状况和FASD结果。在同一样本中，已经实施了多微量营养素补充干预试验。在更新期，我们建议检查产前多微量营养素干预试验有益神经行为效应的持久性和/或新的表现，检查出生后儿童营养在FASD中的作用，并探索遗传和表观遗传因素作为母亲接触和饮酒孕妇风险改变的生物标志物。

DESCRIPTION (provided by applicant): It is estimated that Fetal Alcohol Spectrum Disorders (FASD) is the most common neurodevelopmental disability among children throughout the world. Furthering our understanding of the factors that potentially modify risk for FASD, continue to be critical gaps in research that could drive prevention and intervention strategies throughout the world. A longitudinal cohort sample has been established in Ukraine during the current funding period with detailed documentation of prenatal alcohol exposure, maternal nutritional status, and FASD outcomes. In this same sample a multimicronutrient supplement intervention trial has been implemented. During the renewal period, we propose to examine the persistence of and/or the novel manifestation of beneficial neurobehavioral effects of the prenatal multimicronutrient intervention trial, to examine the role of postnatal child nutrition in FASD, an to explore genetic and epigenetic factors as biomarkers of maternal exposure and risk modification among alcohol consuming pregnant women.