TRACKING HIV INFECTION AND ALCOHOL ABUSE CNS COMORBIDITY WITH NEUROIMAGING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们继续进行一项对照的、自然主义的纵向研究，模拟HIV感染和酗酒对大脑结构和相关功能的累积和渐进影响，并跟踪社区参与者的样本，他们分为4组：单独感染HIV、单独使用障碍、HIV合并AUD，以及没有HIV或AUD的健康对照组。 在这个延续周期中，我们将遵循现有的队列，并招募一个新的队列，该队列也将被跟踪3年。我们将通过新开发的程序来增强MR协议，包括a)高分辨率、各向同性的DTI，在3.0T用于选择性白质纤维束的定量纤维跟踪；b)CT-PRESS光谱分析，以量化肌醇(Mi)、谷氨酸(Glu)、N-乙酰天冬氨酸(NAA)、肌酸+磷酸肌酸(Cr)和胆碱(Cho)，并计算NAA、Cr和Cho的横向松弛时间(T2)；c)纳入额外的神经心理学任务，用于测试大脑结构-功能假说；以及d)通过对神经病变的物理评估和对HIV药物依从性的正式评估来加强临床评估。分析将测试酒精和艾滋病毒共病的双重模型：对被两种疾病破坏的结构(例如，额叶)的交互作用，对仅由一种疾病破坏的结构的相加效应(例如，艾滋病毒感染时的基底节，酒精中毒的小脑)，以及疾病共病产生的协同效应(例如，胼胝体的运动感觉区)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are continuing a controlled, naturalistic longitudinal study modeling cumulative and progressive effects of HIV infection and alcohol abuse, alone and in combination on brain structure and associated function and are following a sample of community participants who fall into 4 groups: HIV infection along, use disorder alone, HIV combined with AUD, and healthy comparison group without either HIV or AUD. In this continuation cycle we will follow the existing cohort and recruit a new cohort who will also be followed for 3 years. We will enhance the MR protocol with newly developed procedures including a) high resolution, isotropic DTI at 3.0 T for quantitative fiber tracking of selective white matter fiber bundles; b) CT-PRESS spectroscopy to quantify myo-Inositol (mI), glutamate (Glu), N-acetylaspartate (NAA), creatine + phosphocreatine (Cr), and choline (Cho) and calculate the transverse relaxation time (T2) for NAA, Cr and Cho; c) incorporate additional neuropsychological tasks for testing brain structure-function hypotheses; and d) augment clinical evaluation with a physical assessment of neuropathy and formal evaluation of HIV medication compliance. Analyses will test a dual model of the comorbidity of alcohol and HIV: interactive effects on structures disrupted by both diseases (e.g., frontal lobes), additive effects on structures disrupted by only one disease (e.g., basal ganglia in HIV infection, cerebellum in alcoholism), and synergistic effects emerging from disease comorbidity (e.g., motor-sensory sector of the corpus callosum).